New hope for tough leukemia: precision drug combo trial launches

NCT ID NCT07522801

Not yet recruiting Disease control Sponsor: Philippe ROUSSELOT Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether personalized drug combinations can help people with relapsed or treatment-resistant T-cell acute lymphoblastic leukemia (T-ALL). Researchers will assign patients to one of several targeted therapies based on lab tests. The main goal is to see if these treatments can achieve complete remission within three months. About 93 participants aged 15 and older will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Venetoclax, Tofacitinib, Everolimus, Enrylaze
What this could lead to: If successful, this could offer a new treatment option for patients with hard-to-treat T-cell leukemia, potentially leading to better remission rates.
What could go wrong: This is an early phase 2 trial with only 93 participants, so results may not apply to everyone. The drug combinations can cause side effects, and the study hasn't started recruiting yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lymphangioleiomyomatosis T-cell acute lymphoblastic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LAL

Contacts and locations

Locations

APHM Conception

Marseille, France
CH Victor Dupouy

Argenteuil, France
CH cote basque

Bayonne, France
CHRU Hopital Bretonneau

Tours, France
CHRU Nancy

Vandœuvre-lès-Nancy, France
CHU Amiens Picardie

Amiens, France
CHU Besancon

Besançon, France
CHU Caen

Caen, France
CHU Clermont Ferrand

Clermont-Ferrand, France
CHU Dijon Bourgogne

Dijon, France
CHU Henri Mondor

Créteil, France
CHU Lille

Lille, France
CHU Nantes

Nantes, France
CHU Nice

Nice, France
CHU Saint Etienne

Saint-Priest-en-Jarez, France
CHU Toulouse

Toulouse, France
CHU de Brest

Brest, France
CHU de Grenoble

Grenoble, France
CHU de Limoges

Limoges, France
CHU de Nîmes

Nîmes, France
CHU de Poitiers

Poitiers, France
CHU de Reims

Reims, France
CHV

Versailles, France
Centre Henri Becquerel

Rouen, France
Centre Hospitalier Regional Metz Thionville

Metz, France
Centre Hospitalier Sud Francilien

Corbeil-Essonnes, France
Centre Hospitalier d'Avignon

Avignon, France
Centre Hospitalier de Dunkerque

Dunkirk, France
Centre Hospitalier de Perpignan

Perpignan, France
Centre Hospitalier de Versailles

Le Chesnay, France
Centre Hospitalier du Pays d'Aix

Aix-en-Provence, France
Chu Angers

Angers, France
Chu Orléans

Orléans, France
Clinique du Parc

Castelnau-le-Lez, France
Czech medical chamber

Prague, Czechia
Erasmus Medical Center

Rotterdam, Netherlands
GHRMSA - Hopital E Muller

Mulhouse, France
HIA Percy

Clamart, France
Hematologist at Hospital Universitario Donostia

San Sebastián, Spain
Hopital Annecy Genevois

Épagny, France
Hopital Armand Trousseau

Paris, France
Hopital Avicenne

Bobigny, France
Hopital Cochin

Paris, France
Hopital Gerneral Universitario Morales Meseguar

Murcia, Spain
Hopital Haut Leveque

Bordeaux, France
Hopital Lyon Sud

Lyon, France
Hopital Necker Enfants Malades

Paris, France
Hopital Pitié Salpêtrière

Paris, France
Hopital Pontchaillou

Rennes, France
Hopital Robert Debré

Paris, France
Hopital Saint Antoine

Paris, France
Hopital Saint Eloi CHU Montpellier

Montpellier, France
Hopital Saint Louis

Paris, France
Hopital Saint Louis

Paris, France
Hopital Victor Provo

Roubaix, France
Hospital General Universitario Gregorio Marnon

Madrid, Spain
Hospital Universitario La Fe

Valencia, Spain
Hospital Universitario Marques de Valdecilla

Santander, Spain
Hospital Universitario Virgen de la Victoria

Málaga, Spain
Hospital Universitario de Salamanca

Salamanca, Spain
Insitut Catala d'Oncologia Badalona

Barcelona, Spain
Institut Gustave Roussy

Villejuif, France
Institut Paoli-Calmettes

Marseille, France
Universidad de Sevilla Facultad de Medicina

Seville, Spain
University Hospital Brno

Brno, Czechia
University Medical Center Utrecht

Utrecht, Netherlands
Universtatsklinikum Frankfurt Med. Klinik II

Frankfurt, Germany
Vall D'Hebron University Hospital

Barcelona, Spain
Wroclaw Medical University

Wroclaw, Poland