New hope for lymphoma patients: targeted drug combo shows promise in late-stage trial

NCT ID NCT04833114

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 23 times

Summary

This study tests whether adding a targeted drug (polatuzumab vedotin) to standard chemotherapy helps people with diffuse large B-cell lymphoma that has come back or not responded to initial treatment. About 306 adults will receive either the new combo or standard therapy. The goal is to see if the new approach keeps the cancer away longer without needing extra treatments.

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Contacts and locations

Locations

  • AKH Meduni Wien Universitätsklinik für Innere Medizin I:

    Vienna, 1090, Austria

  • Belfast City Hospital

    Belfast, BT9 7AB, United Kingdom

  • Clínica Universidad de Navarra (Madrid location)

    Madrid, 28027, Spain

  • Clínica Universidad de Navarra (Pamplona location)

    Pamplona, 31008, Spain

  • Complejo Asistencial Universitario de Salamanca

    Salamanca, 37007, Spain

  • Complejo Hospitalario Universitario de Gran Canaria Dr. Negrín

    Las Palmas de Gran Canaria, 35012, Spain

  • Complejo Hospitalario Universitario de Vigo

    Vigo, 36212, Spain

  • DIAKO Ev.Diakonie-Krankenhaus gemeinnützige GmbH

    Bremen, Germany

  • Derriford Hospital, Plymouth

    Plymouth, PL6 8DH, United Kingdom

  • Georg-August-Universität Göttingen Universitätsmedizin Göttingen

    Göttingen, Germany

  • HELIOS Klinik Berlin-Buch, Klinik für Hämatologie und Stammzelltransplantation

    Berlin, 13125, Germany

  • Hanusch Krankenhaus

    Vienna, 1140, Austria

  • Helios St. Johannes Klinik

    Duisburg, Germany

  • Helios Universitätsklinikum Wuppertal

    Wuppertal, Germany

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital General Universitario de Alicante

    Alicante, 03010, Spain

  • Hospital Germans Trias I Pujol

    Badalona, 08916, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 8035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Fundación Jimenez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39908, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Spain

  • Hospital Universitario Son Espases

    Palma, Balearic Islands, 07120, Spain

  • Hospital Universitario Virgen de la Arrixaca

    Murcia, 30003, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, 41013, Spain

  • Hospital Universitario de Cabueñes

    Gijón, 33394, Spain

  • Hospital Universitario de Donostia

    Donostia / San Sebastian, 20014, Spain

  • Institut Català d'oncologia de L'Hospitalet (ICO-L'Hospitalet)

    L'Hospitalet de Llobregat, 08908, Spain

  • Kepler Universitätsklinikum Med Campus III, Univ.-Klinik für Hämatologie und Internistische Onkologie

    Linz, 4021, Austria

  • Klinik für Onkologie, Hämatologie und Palliativmedizin

    Düsseldorf, 40479, Germany

  • Klinikum Chemnitz gGmbH

    Chemnitz, Germany

  • Klinikum Ludwigshafen

    Ludwigshafen, Germany

  • Klinikum Mutterhaus

    Trier, Germany

  • Klinikum Oldenburg

    Oldenburg, Germany

  • Klinikum Stuttgart

    Stuttgart, Germany

  • Klinikum Wels-Grieskirchen Abteilung für Innere Medizin IV

    Wels, 4600, Austria

  • LKH Hochsteiermark Standort Leoben Abteilung für Innere Medizin Department für Hämato-Onkologie

    Leoben, 8700, Austria

  • Landeskrankenhaus Salzburg

    Salzburg, 5020, Austria

  • Nottingham City Hospital

    Nottingham, NG5 1PB, United Kingdom

  • Ordensklinikum Linz GmbH- Elisabethinen: I. Interne Abteilung Hämato-Onkologie

    Linz, 4020, Austria

  • Philipps-Universität Marburg

    Marburg, Germany

  • Queens Hospital, Romford

    Romford, RM7 0AG, United Kingdom

  • Royal Cornwall Hospital

    Cornwell, TR1 3LJ, United Kingdom

  • St James University Hospital

    Leeds, LS9 7TF, United Kingdom

  • St. Johannes Hospital Dortmund

    Dortmund, Germany

  • Städtisches Klinikum Braunschweig

    Braunschweig, Germany

  • Städtisches Krankenhaus Kiel

    Kiel, Germany

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • UK Graz Universitätsklinik für Innere Medizin Klinische Abteilung für Hämatologie

    Graz, 8036, Austria

  • University Hospital Southampton NHS

    Southampton, S016 6YD, United Kingdom

  • University London College Hospitals

    London, NW1 2PG, United Kingdom

  • Universitätsklinikum Dresden

    Dresden, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, Germany

  • Universitätsklinikum Jena

    Jena, Germany

  • Universitätsklinikum Magdeburg

    Magdeburg, Germany

  • Universitätsklinikum Münster

    Münster, Germany

  • Universitätsklinikum RWTH-Aachen

    Aachen, Germany

  • Universitätsklinikum Ulm

    Ulm, Germany

  • Universitätsmedizin der Johannes Gutenberg-Universität Mainz

    Mainz, Germany

  • Unversitätsmedizin Rostock

    Rostock, Germany

  • Westpfalz-Klinikum GmbH

    Kaiserslautern, Germany

Conditions

Explore the condition pages connected to this study.