New targeted therapy combo aims to boost remission in Tough-to-Treat lymphoma

NCT ID NCT04833114

Completed Disease control Sponsor: GWT-TUD GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tested whether adding the targeted drug polatuzumab vedotin to a standard chemotherapy regimen (R-ICE) helps people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The study enrolled 306 adults whose lymphoma had come back or did not respond to initial treatment. The main goal was to see if the new combination improves event-free survival compared to R-ICE alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Polatuzumab vedotin (a targeted antibody-drug conjugate) combined with rituximab, ifosfamide, carboplatin, and etoposide (chemotherapy)
What this could lead to: If successful, this combination could become a new standard salvage therapy for people with relapsed or refractory DLBCL, potentially improving the chance of remission before a stem cell transplant.
What could go wrong: This is a completed Phase 3 trial, but results are not yet widely published. Adding polatuzumab vedotin may increase side effects like nerve damage or infections, and it may not improve outcomes enough to change current practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DLBCL ASSOCIATED WITH CHRONIC INFLAMMATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma diffuse large B-cell lymphoma with chronic inflammation Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement primary cutaneous diffuse large B-cell lymphoma, Leg type primary mediastinal large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma T-cell/histiocyte rich large B cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA RELAPSED DIFFUSE LARGE B CELL LYMPHOMA

Contacts and locations

Locations

AKH Meduni Wien Universitätsklinik für Innere Medizin I:

Vienna, 1090, Austria
Belfast City Hospital

Belfast, BT9 7AB, United Kingdom
Clínica Universidad de Navarra (Madrid location)

Madrid, 28027, Spain
Clínica Universidad de Navarra (Pamplona location)

Pamplona, 31008, Spain
Complejo Asistencial Universitario de Salamanca

Salamanca, 37007, Spain
Complejo Hospitalario Universitario de Gran Canaria Dr. Negrín

Las Palmas de Gran Canaria, 35012, Spain
Complejo Hospitalario Universitario de Vigo

Vigo, 36212, Spain
DIAKO Ev.Diakonie-Krankenhaus gemeinnützige GmbH

Bremen, Germany
Derriford Hospital, Plymouth

Plymouth, PL6 8DH, United Kingdom
Georg-August-Universität Göttingen Universitätsmedizin Göttingen

Göttingen, Germany
HELIOS Klinik Berlin-Buch, Klinik für Hämatologie und Stammzelltransplantation

Berlin, 13125, Germany
Hanusch Krankenhaus

Vienna, 1140, Austria
Helios St. Johannes Klinik

Duisburg, Germany
Helios Universitätsklinikum Wuppertal

Wuppertal, Germany
Hospital Clinic i Provincial de Barcelona

Barcelona, 08036, Spain
Hospital Clínico Universitario de Valencia

Valencia, 46010, Spain
Hospital General Universitario de Alicante

Alicante, 03010, Spain
Hospital Germans Trias I Pujol

Badalona, 08916, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 8035, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Fundación Jimenez Díaz

Madrid, 28040, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Marqués de Valdecilla

Santander, 39908, Spain
Hospital Universitario Ramón y Cajal

Madrid, Spain
Hospital Universitario Son Espases

Palma, Balearic Islands, 07120, Spain
Hospital Universitario Virgen de la Arrixaca

Murcia, 30003, Spain
Hospital Universitario Virgen del Rocío

Seville, 41013, Spain
Hospital Universitario de Cabueñes

Gijón, 33394, Spain
Hospital Universitario de Donostia

Donostia / San Sebastian, 20014, Spain
Institut Català d'oncologia de L'Hospitalet (ICO-L'Hospitalet)

L'Hospitalet de Llobregat, 08908, Spain
Kepler Universitätsklinikum Med Campus III, Univ.-Klinik für Hämatologie und Internistische Onkologie

Linz, 4021, Austria
Klinik für Onkologie, Hämatologie und Palliativmedizin

Düsseldorf, 40479, Germany
Klinikum Chemnitz gGmbH

Chemnitz, Germany
Klinikum Ludwigshafen

Ludwigshafen, Germany
Klinikum Mutterhaus

Trier, Germany
Klinikum Oldenburg

Oldenburg, Germany
Klinikum Stuttgart

Stuttgart, Germany
Klinikum Wels-Grieskirchen Abteilung für Innere Medizin IV

Wels, 4600, Austria
LKH Hochsteiermark Standort Leoben Abteilung für Innere Medizin Department für Hämato-Onkologie

Leoben, 8700, Austria
Landeskrankenhaus Salzburg

Salzburg, 5020, Austria
Nottingham City Hospital

Nottingham, NG5 1PB, United Kingdom
Ordensklinikum Linz GmbH- Elisabethinen: I. Interne Abteilung Hämato-Onkologie

Linz, 4020, Austria
Philipps-Universität Marburg

Marburg, Germany
Queens Hospital, Romford

Romford, RM7 0AG, United Kingdom
Royal Cornwall Hospital

Cornwell, TR1 3LJ, United Kingdom
St James University Hospital

Leeds, LS9 7TF, United Kingdom
St. Johannes Hospital Dortmund

Dortmund, Germany
Städtisches Klinikum Braunschweig

Braunschweig, Germany
Städtisches Krankenhaus Kiel

Kiel, Germany
The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom
UK Graz Universitätsklinik für Innere Medizin Klinische Abteilung für Hämatologie

Graz, 8036, Austria
University Hospital Southampton NHS

Southampton, S016 6YD, United Kingdom
University London College Hospitals

London, NW1 2PG, United Kingdom
Universitätsklinikum Dresden

Dresden, Germany
Universitätsklinikum Frankfurt

Frankfurt, Germany
Universitätsklinikum Hamburg-Eppendorf

Hamburg, Germany
Universitätsklinikum Jena

Jena, Germany
Universitätsklinikum Magdeburg

Magdeburg, Germany
Universitätsklinikum Münster

Münster, Germany
Universitätsklinikum RWTH-Aachen

Aachen, Germany
Universitätsklinikum Ulm

Ulm, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, Germany
Unversitätsmedizin Rostock

Rostock, Germany
Westpfalz-Klinikum GmbH

Kaiserslautern, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.