New hope for kids with rare seizure disorder: vitamin B6 therapy in final testing phase
NCT ID NCT04706013
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an oral form of pyridoxal 5'-phosphate (P5P), a vitamin B6 derivative, for people with a rare genetic condition called PNPO deficiency. The condition causes hard-to-control seizures. The study will enroll 15 patients aged 2 years and older who already take P5P to manage seizures. Researchers will compare survival and seizure frequency to historical data from untreated patients. The goal is to provide a reliable pharmaceutical-grade P5P option.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Akron's Children's Hospital
RECRUITINGAkron, Ohio, 44308, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Duke Children's Hospital
ACTIVE_NOT_RECRUITINGDurham, North Carolina, 27705, United States
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Lucile Packard Children's Hospital
RECRUITINGPalo Alto, California, 94304, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Queensland Children's Hospital
ACTIVE_NOT_RECRUITINGSouth Brisbane, Queensland, Australia