One-Shot hope: new injection aims to boost platelets before surgery in liver patients

NCT ID NCT07446491

Recruiting now Disease control Sponsor: Chongqing Peg-Bio Biopharm Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a single injection of PN20, a lab-made protein, to see if it can safely raise platelet counts in adults with chronic liver disease who have low platelets and are scheduled for a minor procedure. About 54 participants will receive either PN20 or a placebo. The main goal is to see if platelet counts stay high enough from one day before to seven days after surgery without needing rescue treatment for bleeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PN20 (a lab-made protein that stimulates platelet production)
What this could lead to: If it works, this could offer a short-term way to safely raise platelet counts before surgery, reducing bleeding risk in liver disease patients.
What could go wrong: This is an early-phase trial with only 54 participants, so results may not apply broadly. The drug may not work as expected or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired thrombocytopenia thrombocytopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THROMBOCYTOPENIA ASSOCIATED WITH CHRONIC LIVER DISEASE

Contacts and locations

Locations

Capital Medical University Affiliated Beijing Ditan Hospital
RECRUITING

Beijing, Beijing Municipality, 100015, China
Henan Provincial People's Hospital
RECRUITING

Zhengzhou, Henan, 450003, China
Jilin University First Hospital
RECRUITING

Changchun, Jilin, 130033, China
Liaocheng People's Hospital
RECRUITING

Chaozhou, Shandong, 252000, China
Qingdao Municipal Hospital
RECRUITING

Qingdao, Shandong, 266001, China
The Eighth Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510405, China
The Second Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, 400072, China
Zhenjiang Third People's Hospital
RECRUITING

Zhenjiang, Jiangsu, 212021, China