New injection aims to tame dangerous blood fats

NCT ID NCT06347016

Ongoing Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new injectable drug called plozsiran can safely and effectively lower very high levels of triglycerides (a type of fat) in the blood. About 311 adults with severe hypertriglyceridemia will receive either the drug or a placebo injection every three months for a year. The main goal is to see how much it reduces triglyceride levels compared to the placebo and to monitor for any side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Research Site 1

Birmingham, Alabama, 35205, United States
Research Site 10

North Miami, Florida, 33162, United States
Research Site 100

Kaposvár, 7400, Hungary
Research Site 101

Miskolc, 3530, Hungary
Research Site 102

Pécs, 7623, Hungary
Research Site 103

Zalaegerszeg, 8900, Hungary
Research Site 104

Pécs, 7635, Hungary
Research Site 105

Daugavpils, LV-5417, Latvia
Research Site 106

Daugavpils, LV-5417, Latvia
Research Site 107

Daugavpils, LV-5410, Latvia
Research Site 108

Kuldīga, LV-3301, Latvia
Research Site 109

Riga, LV-1002, Latvia
Research Site 11

Sarasota, Florida, 34239, United States
Research Site 110

Riga, LV-1038, Latvia
Research Site 111

Riga, LV-1050, Latvia
Research Site 112

Tukums, LV-3101, Latvia
Research Site 113

Kaunas, LT-49387, Lithuania
Research Site 114

Kaunas, LT-50177, Lithuania
Research Site 115

Kaunas, LT-48259, Lithuania
Research Site 116

Vilnius, LT-08406, Lithuania
Research Site 117

Vilnius, LT-08406, Lithuania
Research Site 118

Šiauliai, LT-76206, Lithuania
Research Site 119

Christchurch, 8011, New Zealand
Research Site 12

Lawrenceville, Georgia, 30044, United States
Research Site 120

New Plymouth, 4310, New Zealand
Research Site 121

Newtown, 6021, New Zealand
Research Site 122

Bydgoszcz, 85-065, Poland
Research Site 123

Gdynia, 81-338, Poland
Research Site 124

Katowice, 40-156, Poland
Research Site 125

Malbork, 82-200, Poland
Research Site 126

Szczecin, 71-500, Poland
Research Site 127

Wroclaw, 51-314, Poland
Research Site 128

Zamość, 22-400, Poland
Research Site 129

Lodz, 94-255, Poland
Research Site 13

Sugar Hill, Georgia, 30518, United States
Research Site 130

Torun, 87-100, Poland
Research Site 131

Nové Zámky, 94002, Slovakia
Research Site 132

Prešov, 08001, Slovakia
Research Site 133

Rožňava, 04801, Slovakia
Research Site 134

Bratislava, 83101, Slovakia
Research Site 135

Centurion, Gauteng, 0157, South Africa
Research Site 136

Krugersdorp, Gauteng, 1739, South Africa
Research Site 137

Pretoria, Gauteng, 0184, South Africa
Research Site 138

Durban, KwaZulu-Natal, 4449, South Africa
Research Site 139

Cape Town, Western Cape, 7500, South Africa
Research Site 14

Elkhart, Indiana, 46514, United States
Research Site 140

Cape Town, Western Cape, 7500, South Africa
Research Site 141

Somerset West, Western Cape, 7570, South Africa
Research Site 142

Plettenberg Bay, Western Cape, 6600, South Africa
Research Site 143

Cape Town, Western Cape, 7530, South Africa
Research Site 144

Cape Town, Western Cape, 7441, South Africa
Research Site 145

Cape Town, Western Cape, 7925, South Africa
Research Site 146

Mossel Bay, Western Cape, 6500, South Africa
Research Site 147

Madrid, 28041, Spain
Research Site 148

Seville, 41013, Spain
Research Site 149

A Coruña, La Coruña, 15006, Spain
Research Site 15

Indianapolis, Indiana, 46290, United States
Research Site 16

South Bend, Indiana, 46617, United States
Research Site 17

Overland Park, Kansas, 66211, United States
Research Site 18

Topeka, Kansas, 66606, United States
Research Site 19

Metairie, Louisiana, 70001, United States
Research Site 2

Mobile, Alabama, 36604, United States
Research Site 20

Annapolis, Maryland, 21401, United States
Research Site 21

Jackson, Mississippi, 39202, United States
Research Site 22

Fremont, Nebraska, 68025, United States
Research Site 23

Norfolk, Nebraska, 68701, United States
Research Site 24

Morristown, New Jersey, 07960, United States
Research Site 25

The Bronx, New York, 10461, United States
Research Site 26

New York, New York, 10029, United States
Research Site 27

Riverhead, New York, 11901, United States
Research Site 28

Asheboro, North Carolina, 27203, United States
Research Site 29

Wilmington, North Carolina, 28412, United States
Research Site 3

Beverly Hills, California, 90211, United States
Research Site 30

Beavercreek, Ohio, 45431, United States
Research Site 31

Columbus, Ohio, 43214, United States
Research Site 32

Oklahoma City, Oklahoma, 73112, United States
Research Site 33

Horsham, Pennsylvania, 19044, United States
Research Site 34

Newport, Pennsylvania, 17074, United States
Research Site 35

Philadelphia, Pennsylvania, 19104, United States
Research Site 36

Philadelphia, Pennsylvania, 19104, United States
Research Site 37

Fort Mill, South Carolina, 29707, United States
Research Site 38

Greenville, South Carolina, 29607, United States
Research Site 39

Chattanooga, Tennessee, 37411, United States
Research Site 4

Canoga Park, California, 91303, United States
Research Site 40

Fort Worth, Texas, 76132, United States
Research Site 41

Houston, Texas, 77040, United States
Research Site 42

Houston, Texas, 77090, United States
Research Site 43

Houston, Texas, 77090, United States
Research Site 44

Sugar Land, Texas, 77479, United States
Research Site 45

Tomball, Texas, 77375, United States
Research Site 46

Victoria, Texas, 77901, United States
Research Site 47

Bountiful, Utah, 84010, United States
Research Site 48

St. George, Utah, 84790, United States
Research Site 49

Manassas, Virginia, 20110, United States
Research Site 5

Huntington Beach, California, 92648, United States
Research Site 50

Roanoke, Virginia, 24014, United States
Research Site 51

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1056ABJ, Argentina
Research Site 52

CABA, Buenos Aires, 1128, Argentina
Research Site 53

Godoy Cruz, Mendoza Province, 5501, Argentina
Research Site 54

Córdoba, Córdoba Province, 5003, Argentina
Research Site 55

Rosario, Santa Fe Province, 2000, Argentina
Research Site 56

Brasília, Federal District, 70710, Brazil
Research Site 57

Campinas, São Paulo, 13060, Brazil
Research Site 58

Santo André, São Paulo, 09080, Brazil
Research Site 59

Belo Horizonte, Minas Gerais, 30150, Brazil
Research Site 6

Lincoln, California, 95648, United States
Research Site 60

São José do Rio Preto, São Paulo, 15090, Brazil
Research Site 61

Salvador, Estado de Bahia, 40170, Brazil
Research Site 62

Aracaju, Sergipe, 49055-530, Brazil
Research Site 63

Recife, 52051-380, Brazil
Research Site 64

Byala, 7100, Bulgaria
Research Site 65

Dimitrovgrad, 6400, Bulgaria
Research Site 66

Haskovo, 6300, Bulgaria
Research Site 67

Kyustendil, 2500, Bulgaria
Research Site 68

Rousse, 7013, Bulgaria
Research Site 69

Sevlievo, 5400, Bulgaria
Research Site 7

Long Beach, California, 90822, United States
Research Site 70

Sofia, 1431, Bulgaria
Research Site 71

Sofia, 1510, Bulgaria
Research Site 72

Sofia, 1680, Bulgaria
Research Site 73

Sofia, 1431, Bulgaria
Research Site 74

Sofia, 1750, Bulgaria
Research Site 75

Sofia, 1616, Bulgaria
Research Site 76

Sofia, 1202, Bulgaria
Research Site 77

Stara Zagora, 6003, Bulgaria
Research Site 78

North Vancouver, British Columbia, V7M 2H4, Canada
Research Site 79

Chicoutimi, Quebec, G7H 7K9, Canada
Research Site 8

Oxnard, California, 93030, United States
Research Site 80

Laval, Quebec, H7T 2P5, Canada
Research Site 81

Québec, Quebec, G1G 3Y8, Canada
Research Site 82

Terrebonne, Quebec, J6V2H2, Canada
Research Site 83

Brno, 65691, Czechia
Research Site 84

Náchod, 547 01, Czechia
Research Site 85

Olomouc, 77900, Czechia
Research Site 86

Prague, 100 00, Czechia
Research Site 87

Trutnov, 541 01, Czechia
Research Site 88

Slaný, 15006, Czechia
Research Site 89

Teplice, 41501, Czechia
Research Site 9

Clearwater, Florida, 33756, United States
Research Site 90

Paris, 75013, France
Research Site 91

Marseille, Bouches-du-Rhône, 13005, France
Research Site 92

Pessac, Gironde, 33604, France
Research Site 93

Bayonne, Pyrenees Atlantiques, 64100, France
Research Site 94

Lyon, Rhone, 69007, France
Research Site 95

Deggingen, Baden-Wurttemberg, 73326, Germany
Research Site 96

Wallerfing, Bavaria, 94574, Germany
Research Site 97

Magdeburg, Saxony-Anhalt, Germany
Research Site 98

Berlin, State of Berlin, 13353, Germany
Research Site 99

Békéscsaba, 5600, Hungary

Conditions

Explore the condition pages connected to this study.

SEVERE HYPERTRIGLYCERIDEMIA