New injection aims to tame dangerous blood fats

NCT ID NCT06347003

Ongoing Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new injectable drug called plozasiran can safely and effectively lower very high levels of triglycerides (a type of fat) in the blood. About 446 adults with severe hypertriglyceridemia will receive either the drug or a placebo injection every three months for a year. The main goal is to see how much it reduces triglyceride levels compared to the placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Research Center 1

Garden Grove, California, 92844, United States
Research Center 1

Buenos Aires, C1430, Argentina
Research Center 1

Blacktown, New South Wales, 2148, Australia
Research Center 1

Wetteren, 9230, Belgium
Research Center 1

Campinas, São Paulo, 13083-190, Brazil
Research Center 1

Pleven, 5800, Bulgaria
Research Center 1

Brampton, Ontario, L6S 0C6, Canada
Research Center 1

Beijing, Xicheng, 10034, China
Research Center 1

Zagreb, City of Zagreb, 10000, Croatia
Research Center 1

Ostrava, 70200, Czechia
Research Center 1

Budapest, 1033, Hungary
Research Center 1

Roma, 00168, Italy
Research Center 1

Bucharest, București, 010192, Romania
Research Center 1

Košice, Košice Region, 040 01, Slovakia
Research Center 1

Valencia, 46010, Spain
Research Center 1

London, EC1M 6BQ, United Kingdom
Research Center 10

Mt. Dora, Florida, 32757, United States
Research Center 10

San Isidro, Buenos Aires, 1642, Argentina
Research Center 10

Vitória, Espírito Santo, 29055-450, Brazil
Research Center 10

Kardzhali, 6600, Bulgaria
Research Center 10

Suzhou, Jiangsu, 215002, China
Research Center 10

Katowice, 40-752, Poland
Research Center 11

Orlando, Florida, 32825, United States
Research Center 11

São Paulo, São Paulo, 05403-000, Brazil
Research Center 11

Rousse, Ruse, 7000, Bulgaria
Research Center 11

Bengbu, Anhui, 233004, China
Research Center 11

Elblag, 82-300, Poland
Research Center 12

Pensacola, Florida, 32503, United States
Research Center 12

Salvador, Estado de Bahia, 40050-410, Brazil
Research Center 12

Blagoevgrad, 2700, Bulgaria
Research Center 12

Shanghai, Shanghai Municipality, 200050, China
Research Center 12

Lodz, 91-363, Poland
Research Center 13

Tamarac, Florida, 33321, United States
Research Center 13

Salvador, Estado de Bahia, 40323-010, Brazil
Research Center 13

Sofia, 1336, Bulgaria
Research Center 13

Xingtai, Hebei, 054099, China
Research Center 13

Krakow, 30-727, Poland
Research Center 14

Tampa, Florida, 33614, United States
Research Center 14

Salvador, Estado de Bahia, 41810-010, Brazil
Research Center 14

Sofia, 1680, Bulgaria
Research Center 14

Nanchang, 330006, China
Research Center 14

Wroclaw, 53-673, Poland
Research Center 15

Macon, Georgia, 31210, United States
Research Center 15

Sofia, Sofia, 1527, Bulgaria
Research Center 15

Wenzhou, Zhejiang, 325000, China
Research Center 15

Żarów, Swidnica, 58-130, Poland
Research Center 16

Savannah, Georgia, 31401, United States
Research Center 16

Baotou, Inner Mongolia, 14010, China
Research Center 16

Wroclaw, 53-030, Poland
Research Center 17

Park Ridge, Illinois, 60068, United States
Research Center 17

Chengdu, Sichuan, 610072, China
Research Center 17

Krakow, 31-202, Poland
Research Center 18

Eunice, Louisiana, 70535, United States
Research Center 18

Changsha, Hunan, 410015, China
Research Center 18

Warsaw, 00-215, Poland
Research Center 19

Baltimore, Maryland, 21229, United States
Research Center 19

Guanzhou, Guangdong, 510080, China
Research Center 2

Lake Forest, California, 92630, United States
Research Center 2

Buenos Aires, C1425AGC, Argentina
Research Center 2

Box Hill, Victoria, 3138, Australia
Research Center 2

Namur, 5101, Belgium
Research Center 2

Curitiba, Paraná, 80730-150, Brazil
Research Center 2

Plovdiv, 4002, Bulgaria
Research Center 2

Sarnia, Ontario, N7T 4X3, Canada
Research Center 2

Yuncheng, Shanxi, 44000, China
Research Center 2

Krapinske Toplice, 49217, Croatia
Research Center 2

Uherské Hradiště, 68601, Czechia
Research Center 2

Budapest, 1132, Hungary
Research Center 2

Palermo, Sicily, 90127, Italy
Research Center 2

Cluj-Napoca, Cluj, 400000, Romania
Research Center 2

Žilina, Žilina Region, 10010, Slovakia
Research Center 2

Barcelona, 08023, Spain
Research Center 2

Plymouth, Devpn, PL5 3JB, United Kingdom
Research Center 20

Flint, Michigan, 48532, United States
Research Center 20

Tianjin, Tianjin Municipality, 300121, China
Research Center 21

Minneapolis, Minnesota, 55455, United States
Research Center 21

Wuhan, Hubei, 430060, China
Research Center 22

Olive Branch, Mississippi, 38654, United States
Research Center 22

Beijing, Beijing Municipality, 100730, China
Research Center 23

Jefferson City, Missouri, 65109, United States
Research Center 23

Beijing, Beijing Municipality, 100191, China
Research Center 24

St Louis, Missouri, 63136, United States
Research Center 25

Omaha, Nebraska, 68144, United States
Research Center 26

Omaha, Nebraska, 68114, United States
Research Center 27

Las Vegas, Nevada, 89119, United States
Research Center 28

The Bronx, New York, 10455, United States
Research Center 29

Long Island City, New York, 11106, United States
Research Center 3

Montclair, California, 91763, United States
Research Center 3

Córdoba, Córdoba Province, X5006CBI, Argentina
Research Center 3

Heidelberg, Victoria, 3084, Australia
Research Center 3

Mechelen, 2800, Belgium
Research Center 3

Votuporanga, São Paulo, 15501-405, Brazil
Research Center 3

Pleven, 5800, Bulgaria
Research Center 3

Victoria, British Columbia, V8T 5G4, Canada
Research Center 3

Liaocheng, 252000, China
Research Center 3

Zagreb, 10000, Croatia
Research Center 3

Hodonín, 69501, Czechia
Research Center 3

Szeged, 6725, Hungary
Research Center 3

Rozzano, Milano, 20089, Italy
Research Center 3

Brasov, Brașov County, 500091, Romania
Research Center 3

Moldava nad Bodvou, Košice Region, 045 01, Slovakia
Research Center 3

Barcelona, 08035, Spain
Research Center 3

Torpoint, Cornwall, PL11 2TB, United Kingdom
Research Center 30

New York, New York, 10016, United States
Research Center 31

Rochester, New York, 14642, United States
Research Center 32

Vestal, New York, 13850, United States
Research Center 33

Morehead City, North Carolina, 28557, United States
Research Center 34

Winston-Salem, North Carolina, 27157, United States
Research Center 35

Cincinnati, Ohio, 45219, United States
Research Center 36

Columbus, Ohio, 43210, United States
Research Center 37

Norman, Oklahoma, 73072, United States
Research Center 38

Oklahoma City, Oklahoma, 73111, United States
Research Center 39

Powell, Tennessee, 37849, United States
Research Center 4

Panorama City, California, 91402, United States
Research Center 4

Córdoba, Córdoba Province, 5000, Argentina
Research Center 4

Concord, New South Wales, 2139, Australia
Research Center 4

Gozée, 6534, Belgium
Research Center 4

Belém, Pará, 66073-000, Brazil
Research Center 4

Plovdiv, 4001, Bulgaria
Research Center 4

Québec, Quebec, G1V 4W2, Canada
Research Center 4

Changsha, Hunan, 410011, China
Research Center 4

Zagreb, 10000, Croatia
Research Center 4

Prague, Prague, 140 59, Czechia
Research Center 4

Budapest, 1051, Hungary
Research Center 4

Milan, 20162, Italy
Research Center 4

Ploieşti, Jud. Prahova, 100342, Romania
Research Center 4

Banská Bystrica, Banská Bystrica Region, 97401, Slovakia
Research Center 4

Zaragoza, 50009, Spain
Research Center 4

London, N12 8BU, United Kingdom
Research Center 40

El Paso, Texas, 79905, United States
Research Center 41

Houston, Texas, 77095, United States
Research Center 42

Houston, Texas, 77061, United States
Research Center 43

Houston, Texas, 77079, United States
Research Center 44

Houston, Texas, 77074, United States
Research Center 45

Houston, Texas, 77030, United States
Research Center 46

Houston, Texas, 77030, United States
Research Center 47

Houston, Texas, 77029, United States
Research Center 48

Laredo, Texas, 78041, United States
Research Center 49

Missouri City, Texas, 77459, United States
Research Center 5

Redding, California, 96001, United States
Research Center 5

Córdoba, Córdoba Province, X5000AAW, Argentina
Research Center 5

Merewether, New South Wales, 2291, Australia
Research Center 5

Roeselare, 8800, Belgium
Research Center 5

Belo Horizonte, Minas Gerais, 30220-140, Brazil
Research Center 5

Sofia, 1431, Bulgaria
Research Center 5

Waterloo, Ontario, N2TOC1, Canada
Research Center 5

Hangzhou, 311100, China
Research Center 5

Praha 4-Krc, 140 59, Czechia
Research Center 5

Veszprém, 8200, Hungary
Research Center 5

Brescia, 25123, Italy
Research Center 5

Timișoara, Timiș County, 300362, Romania
Research Center 5

Bratislava, 81109, Slovakia
Research Center 5

Torquay, Devon, TQ2 7AA, United Kingdom
Research Center 50

Plano, Texas, 75093, United States
Research Center 51

San Antonio, Texas, 78230, United States
Research Center 52

Seattle, Washington, 98109, United States
Research Center 6

Colorado Springs, Colorado, 80909, United States
Research Center 6

Buenos Aires, C1417, Argentina
Research Center 6

Crawley, Western Australia, 6009, Australia
Research Center 6

Hasselt, 3500, Belgium
Research Center 6

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Research Center 6

Sofia, 1404, Bulgaria
Research Center 6

Montreal, Quebec, H2W 1R7, Canada
Research Center 6

Luoyang, Henan, 471003, China
Research Center 6

Hradec Králové, 50005, Czechia
Research Center 6

Budapest, 1152, Hungary
Research Center 6

Bologna, 40138, Italy
Research Center 6

Alba Iulia, Jud. Alba, 510053, Romania
Research Center 6

Bardejov, 08501, Slovakia
Research Center 7

Hialeah, Florida, 33016, United States
Research Center 7

Temperley, Buenos Aires, B1834GUK, Argentina
Research Center 7

Clayton, Victoria, 3168, Australia
Research Center 7

São Paulo, São Paulo, 04266-010, Brazil
Research Center 7

Sofia, Sofia, 1527, Bulgaria
Research Center 7

Halifax, B3H 1V7, Canada
Research Center 7

Guangzhou, Guangdong, 510180, China
Research Center 7

Praha 1-Nove Mesto, 11000, Czechia
Research Center 7

Bydgoszcz, 85-231, Poland
Research Center 7

Galati, 800291, Romania
Research Center 8

Lake City, Florida, 32055, United States
Research Center 8

Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Research Center 8

Campina Grande do Sul, Paraná, 83430-000, Brazil
Research Center 8

Burgas, Burgas, 8000, Bulgaria
Research Center 8

London, Ontario, N6A 5A5, Canada
Research Center 8

Liuchow, Guangxi Zhuang, 545006, China
Research Center 8

Prague, Prague, 140 21, Czechia
Research Center 8

Krakow, 31-501, Poland
Research Center 8

Deva, 330084, Romania
Research Center 9

Miami Lakes, Florida, 33014, United States
Research Center 9

Córdoba, Córdoba Province, 5008, Argentina
Research Center 9

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Research Center 9

Plovdiv, 4004, Bulgaria
Research Center 9

Shanghai, Shanghai Municipality, 2000040, China
Research Center 9

Ústí nad Labem, 40113, Czechia
Research Center 9

Warsaw, 03-291, Poland
Research Center 9

Târgu Mureş, 540136, Romania

Conditions

Explore the condition pages connected to this study.

SEVERE HYPERTRIGLYCERIDEMIA