Can a collagen booster fix 'Ozempic Face'? new trial aims to find out
NCT ID NCT07478198
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injections of poly-L-lactic acid (PLLA) can safely improve facial sagging and wrinkles in people who lost significant weight using GLP-1 drugs like semaglutide. Twenty-two adults aged 30-60 will receive three PLLA sessions, one month apart. Researchers will measure changes in wrinkle severity and overall appearance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Poly-L-lactic acid (PLLA) injection
- What this could lead to
- If it works, this could offer a non-surgical option to restore facial volume and reduce sagging after weight loss from GLP-1 drugs.
- What could go wrong
- This is a very small early study with only 22 people, no comparison group, and results may not apply to everyone. Risks include injection side effects like swelling or lumps.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Shanghai Punan Hospital of Pudong New District
Shanghai, Shanghai Municipality, China
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