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Blood injections may shorten time in braces, small study suggests

NCT ID NCT07408895

Symptom relief Sponsor: Sana'a University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injecting platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) — made from a patient's own blood — into the gums could speed up the movement of a specific tooth during braces treatment. Twenty-one healthy young adults participated, and each person served as their own control. The goal was to see if these injections could reduce the time needed for orthodontic treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) from the patient's own blood
What this could lead to
If it works, this could shorten the time needed for braces by speeding up tooth movement.
What could go wrong
This is a small, early study with only 21 people, so results may not apply to everyone. The effect may be small or not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

May 2024

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

17 to 29 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy individuals aged 17-29 years (mean age 24 ± 6 years) * Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions * Full permanent dentition * Good oral hygiene * Non-smokers * Not taking medications affecting bone metabolism (e.g., bisphosphonates) Exclusion Criteria: * Pregnancy or breastfeeding * Contraindications to platelet therapies (e.g., platelet dysfunction) * Severe malocclusion unsuitable for fixed appliances * Dental anomalies (size/shape) * Systemic syndromes

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Accelerate tooth movement

Contacts and locations

Locations

  • Faculty of Dentistry, Sana'a University

    Sanaa, Yemen