Plant-Based diet shows promise for prediabetes in tiny study

NCT ID NCT06571279

Completed Prevention Sponsor: Jean L. Fry Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested whether switching from a Western diet to a plant-based diet for 5 weeks could improve insulin sensitivity in 9 adults with prediabetes. Participants received all meals and snacks, and researchers measured changes in insulin sensitivity and muscle inositol levels. The goal is to see if diet alone can help prevent type 2 diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Plant-based diet
What this could lead to: If it works, this could point toward a simple dietary approach to prevent type 2 diabetes in people with prediabetes.
What could go wrong: This is a very small, early study with only 9 participants and no control group, so results may not apply widely. The diet is short-term and tightly controlled, so real-world adherence could be challenging.

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Conditions

The condition(s) this trial relates to.

glucose intolerance Insulin Resistance prediabetes syndrome diabetes mellitus prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREDIABETES (INSULIN RESISTANCE, IMPAIRED GLUCOSE TOLERANCE)

Contacts and locations

Locations

University of Kentucky CCTS

Lexington, Kentucky, 40536, United States

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