New injection offers hope for teens with rare genetic disorder

NCT ID NCT05270837

Summary

This study is testing whether daily injections of a medication called pegvaliase are safe and effective for teenagers with PKU, a genetic disorder that makes it hard to process protein. About 55 teens will be randomly assigned to receive either the injections or continue managing their PKU with a strict diet alone. The main goal is to see if the injections lower the level of a harmful substance in the blood better than diet management.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Ann and Robert H. Lurie Children's Hospital of Chicago

    Chicago, Illinois, 60611, United States

  • Arkansas Children's Hospital

    Little Rock, Arkansas, 72202, United States

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Charité - Universitätsmedizin Berlin

    Berlin, Germany

  • Children's Hospital of Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • IU Health University Hospital

    Indianapolis, Indiana, 46202, United States

  • McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth)

    Houston, Texas, 77030, United States

  • Phoenix Children's Hospital

    Phoenix, Arizona, 85016, United States

  • Universitat Mainz

    Mainz, Germany

  • University of Kentucky College of Medicine

    Lexington, Kentucky, 40506, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15224, United States

  • University of South Florida

    Tampa, Florida, 33606, United States

  • University of Utah Medical Center

    Salt Lake City, Utah, 84132, United States

  • University of Virginia School of Medicine

    Charlottesville, Virginia, 22903, United States

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, Germany

Conditions

Explore the condition pages connected to this study.