New pill shows promise for frail elderly lymphoma patients
NCT ID NCT07207785
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 study tests pirtobrutinib, a daily oral drug, as a first treatment for elderly patients (70+) with mantle cell lymphoma who are considered unfit or frail. The goal is to see if the drug can control the cancer and delay progression. 56 participants will take the drug until the disease worsens or side effects become unacceptable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pirtobrutinib (Jaypirca), a targeted oral drug
What this could lead to
If successful, this could offer a gentler, effective treatment option for elderly patients with mantle cell lymphoma who cannot tolerate standard chemotherapy.
What could go wrong
This is a small, early-phase study (56 participants) with no comparison group. The drug may not control the cancer long-term, and side effects are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia
Palermo, Italy
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A.O. S. Maria di Terni - S.C. Oncoematologia
Terni, Italy
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AOU Integrata di Verona - U.O. Ematologia
Verona, Italy
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AOU Ospedali Riuniti - Clinica di Ematologia
Ancona, Italy
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AOU Senese - U.O.C. Ematologia
Siena, Italy
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ASST Spedali Civili di Brescia - Ematologia
Brescia, Italy
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Azienda Ospedaliera S.Giuseppe Moscati - S.C. Ematologia e Trapianto emopoietico
Avellino, Italy
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Azienda Ospedaliera Universitaria Policlinico - S. Marco - UOC di Ematologia
Catania, Italy
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Azienda USL Piacenza - UOC Ematologia e Centro Trapianti
Piacenza, Italy
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Azienda Unitа Sanitaria Locale-IRCCS - Arcispedale Santa Maria Nuova - Ematologia
Reggio Emilia, Italy
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Fondazione IRCCS Istituto Nazionale dei Tumori di Milano - Ematologia
Milan, Italy
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IRCCS Istituto Romagnolo per lo studio dei Tumori "Dino Amadori" - IRST S.R.L. - Ematologia
Meldola, Forlì-Cesena, Italy
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Istituto Clinico Humanitas - U.O. Ematologia
Rozzano, Milano, Italy
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Nuovo Ospedale degli Infermi - SSD Ematologia
Biella, Italy
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Ospedale Ca Foncello - S.C di Ematologia
Treviso, Italy
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Ospedale di Circolo - U.O.C Ematologia
Varese, Italy
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P.O. Spirito Santo di Pescara - UOC Ematologia Dipartimento Oncologico Ematologico - ASL Pescara
Pescara, Italy
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Parma - AOU di Parma - UOC Ematologia e CTMO
Parma, Italy
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Policlinico S.Orsola-Malpighi - Istituto di Ematologia "Seragnoli"
Bologna, Italy
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Vicenza - ULSS 8 Berica - Ospedale S. Bortolo - Ematologia
Vicenza, Italy
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