New drug cocktail shows promise for Hard-to-Treat leukemia

NCT ID NCT01861314

First seen Oct 31, 2025 · Last updated Apr 29, 2026 · Updated 23 times

Summary

This early-phase study tests a combination of three drugs (bortezomib, sorafenib, and decitabine) in 15 adults with acute myeloid leukemia (AML), including older patients who cannot have standard treatment or those with relapsed disease. The main goal is to find the safest dose and identify side effects. Researchers also look at how the treatment affects certain biomarkers and whether it can lead to remission.

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Contacts and locations

Locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

Conditions

Explore the condition pages connected to this study.