Can a simple pH change make dental shots Pain-Free?
NCT ID NCT07318311
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether adjusting the pH of a numbing solution (articaine with epinephrine) improves pain relief during needle-free dental injections. Forty-five healthy adults received injections with and without pH adjustment. The goal was to see if the change makes anesthesia more effective and comfortable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- articaine with epinephrine
- What this could lead to
- If it works, this could make dental injections less painful and more comfortable for patients.
- What could go wrong
- This is a small, early study with only 45 healthy adults, so results may not apply to everyone. The pH adjustment might not improve pain relief significantly.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dental School Aristotle University of Thessaloniki
Thessaloniki, 54124, Greece