Can a simple pH change make dental shots Pain-Free?
NCT ID NCT07318311
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether adjusting the pH of a numbing solution (articaine with epinephrine) improves pain relief during needle-free dental injections. Forty-five healthy adults received injections with and without pH adjustment. The goal was to see if the change makes anesthesia more effective and comfortable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
articaine with epinephrine
What this could lead to
If it works, this could make dental injections less painful and more comfortable for patients.
What could go wrong
This is a small, early study with only 45 healthy adults, so results may not apply to everyone. The pH adjustment might not improve pain relief significantly.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dental School Aristotle University of Thessaloniki
Thessaloniki, 54124, Greece