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Personalized vaccine shows promise against deadly skin cancer

NCT ID NCT03815058

Completed Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a personalized cancer vaccine (autogene cevumeran) to standard immunotherapy (pembrolizumab) works better than immunotherapy alone for people with advanced melanoma that hasn't been treated before. The trial involved 131 patients with advanced skin cancer who received either the combination treatment or just the standard immunotherapy. Researchers measured how long patients lived without their cancer getting worse, how many responded to treatment, and monitored side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Alfred Hospital

    Melbourne, Victoria, 3181, Australia

  • Antwerp University Hospital

    Edegem, 2650, Belgium

  • Atlanta Cancer Care

    Alpharetta, Georgia, 30005, United States

  • Barts and The London

    London, EC1M 6BQ, United Kingdom

  • Cancer Specialists

    Jacksonville, Florida, 32256, United States

  • Case Western Research University

    Cleveland, Ohio, 44106-5067, United States

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Clinica Universidad de Navarra

    Pamplona, Navarre, 31008, Spain

  • Elbe Kliniken Stade-Buxtehude GmbH

    Buxtehude, 21614, Germany

  • Fachklinik Hornheide

    Münster, 48157, Germany

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital Universitario La Paz

    Madrid, 280146, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Instituto Oncológico Dr. Rosell

    Barcelona, 08028, Spain

  • Intermountain Surgical Oncology

    Murray, Utah, 84107, United States

  • Liverpool Hospital

    Liverpool, New South Wales, 2170, Australia

  • Massachusetts General Hospital.

    Boston, Massachusetts, 02114, United States

  • Med. Fakultat Mannheim der Universitat Heidelberg

    Mannheim, 68167, Germany

  • Moffitt McKinley Outpatient Center

    Tampa, Florida, 33612, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria, 3000, Australia

  • Sarah Cannon Research Institute / Tennessee Oncology

    Nashville, Tennessee, 37203, United States

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98109, United States

  • St. John of God - Subiaco Hospital

    Subiaco, Western Australia, 6008, Australia

  • The Queen Elizabeth Hospital

    Woodville South, South Australia, 5011, Australia

  • UCSF Comprehensive Cancer Ctr

    San Francisco, California, 94115, United States

  • Uni Schleswig-Holstein

    Lübeck, 23562, Germany

  • Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Hautklinik und Poliklinik

    Mainz, 55131, Germany

  • Universitatsklinikum Eppendorf

    Hamburg, 20246, Germany

  • University of California San Diego Moores Cancer Center

    La Jolla, California, 92037, United States

  • University of Colorado

    Denver, Colorado, 80262, United States

  • University of Virginia

    Charlottesville, Virginia, 22906, United States

  • Universitätshautk. Tübingen

    Tübingen, 72076, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitätsklinikum Koeln

    Cologne, 50937, Germany

  • Vall d?Hebron Institute of Oncology (VHIO), Barcelona

    Barcelona, 08035, Spain

  • Washington University

    St Louis, Missouri, 63110, United States

  • ZAS Sint Augustinus Wilrijk

    Wilrijk, 2610, Belgium

Conditions

Explore the condition pages connected to this study.

ADVANCED MELANOMA