Brain training eyed as way to sharpen blurry vision in keratoconus
NCT ID NCT05220904
First seen Sep 11, 2026 · Last updated Sep 11, 2026
Summary
Researchers are testing whether perceptual learning, a computer-based training that aims to improve how the brain processes visual information, can help people with stable keratoconus see better with their glasses. The study enrolls people aged 9 and older whose best corrected vision is still unsatisfactory. Participants are randomly assigned to receive either perceptual learning training or standard spectacle correction, and researchers measure changes in corrected and uncorrected vision and contrast sensitivity over 15 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- perceptual learning, a computer-based visual training program
- What this could lead to
- If it works, perceptual learning could offer a non-surgical way to help people with keratoconus see more clearly with their glasses.
- What could go wrong
- This is a small study of 35 people with stable keratoconus, so results may not apply to everyone. Any vision gains might fade over time, and training takes repeated sessions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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35 people
The number who actually took part.
- Started
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Feb 2022
- Finished
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Sep 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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9 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged 9 years or older; 2. Has been diagnosed as Keratoconus,BAD-D≥2.6; 3. Change of Kmax \< 1.0 D and change of BAD-D \<0.4175 betweem the last two Pentacam result; 4. The best corrected visual acuity of both eyes was between 0.1 and 1.0; 5. Has voluntarily agreed to participate in the study by signing the statement of informed consent. Exclusion Criteria: 1. Has history of acute keratoconus; 2. Has other eye diseases or other diseases/conditions causing vision loss; 3. Has eye surgery history in the past 1year; 4. Is currently using local/systemic medications or other interventions that may affect visual function; 5. Receiving other treatments that may affect the results of this study, such as contact lenses during the study; 6. Has any known neurological diseases; 7. Participating in other studies currently that may affect the results of this study; 8. Study other reasons that the physician considers inappropriate for inclusion in the program.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, 510060, China
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