Targeted drug tested for hard-to-treat cancers based on genetic fingerprint

NCT ID NCT03822117

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This study tested whether the drug pemigatinib could help control advanced solid tumors that had specific genetic changes (FGFR mutations or fusions) and had stopped responding to other treatments. It involved 111 adults whose cancer had spread or could not be removed by surgery. The main goal was to see if the tumor shrank in response to the daily oral medication and to monitor side effects.

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Contacts and locations

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Locations

A.P.H. Paris Hopital Cochin

Paris, 75014, France
Assaf Harofeh Medical Center

Ẕerifin, 7030000, Israel
CENTRE GEORGES FRANï¿½OIS LECLERC

Dijon, 21079, France
Cancer Institute of Greenville Health System

Greenville, South Carolina, 29605, United States
Cancer Treatment Centers of America

Goodyear, Arizona, 85338, United States
Cancer Treatment Centers of America

Zion, Illinois, 60099, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Central Maine Medical Center

Lewiston, Maine, 04240, United States
Centre Antoine Lacassagne

Nice, 06189, France
Centro Integral Oncologico Clara Campal (Ciocc)

Madrid, 28050, Spain
Centro Ricerche Cliniche Di Verona (Crc)

Verona, 37134, Italy
Chao Family Comprehensive Cancer Center University of California, Irvine

Orange, California, 92868, United States
Clinica Universidad de Navarra (Cun)

Pamplona, 31008, Spain
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Duke Cancer Center

Durham, North Carolina, 27710, United States
Edward H Kaplan & Associates

Skokie, Illinois, 60076, United States
Florida Cancer Specialists

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists

Tallahassee, Florida, 32308, United States
Florida Cancer Specialists

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists & Research Institute

Fort Myers, Florida, 33901, United States
Fondazione Del Piemonte Per L Oncologia Ircc Candiolo

Candiolo, 10060, Italy
Fondazione Irccs Istituto Nazionale Dei Tumori

Milan, 20133, Italy
Ha Emek Medical Center

Afula, 18101, Israel
Hadassah Hebrew University Medical Center Ein Karem Hadassah

Jerusalem, 90000, Israel
Hospital Clinic I Provincial

Barcelona, 08036, Spain
Hospital General Universitario Vall D Hebron

Barcelona, 08035, Spain
Hospital Regional Universitario de Malaga

Málaga, 29010, Spain
Hospital Saint Louis

Paris, 75010, France
Hospital Universitario Marques de Valdecilla

Santander, 39008, Spain
Hospital Universitario Y Politcnico de La Fe

Valencia, 46026, Spain
Houston Methodist Hospital

Houston, Texas, 77030, United States
Illinois Cancer Specialists

Arlington Heights, Illinois, 60005, United States
Imperial College Healthcare Nhs Trust - Hammersmith Hospital

London, W12 0HS, United Kingdom
Indiana University Health - Arnett Cancer Care

Lafayette, Indiana, 47904, United States
Inselspital - Universitaetsspital Bern

Bern, 03010, Switzerland
Institut Bergonie

Bordeaux, 33000, France
Institut Universitaire Du Cancer de Toulouse Oncopole

Toulouse, 31059, France
Istituto Nazionale Tumori Irccs Fondazione Pascale

Napoli, 80131, Italy
Istituto Nazionale Tumori Regina Elena Irccs

Roma, 00144, Italy
Joe Arrington Cancer Center

Lubbock, Texas, 79410, United States
John Wayne Cancer Institute

Santa Monica, California, 90404, United States
Kanagawa Cancer Center

Yokohama, 241-8515, Japan
Kanazawa University Hospital

Ishikawa, 920-8641, Japan
Keio University Hospital

Shinjuku-ku, 160-8582, Japan
Kobe University Hospital

Kobe, 650-0017, Japan
L AZIENDA OSPEDALIERO-UNIVERSITARIA DI BOLOGNA POLICLINICO S. ORSOLA ï¿½ MALPIGHI

Bologna, 40138, Italy
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Hospital

Phoenix, Arizona, 85054, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Multicare Institute For Research & Innovation

Tacoma, Washington, 98405, United States
National Cancer Center

Goyang-si, 10408, South Korea
National Hospital Organization Kyushu Cancer Center

Fukuoka, 811-1395, Japan
Ochsner Clinic

New Orleans, Louisiana, 70121, United States
Oncology Specialists of Charlotte

Charlotte, North Carolina, 28204, United States
Rabin Medical Center - Beilinson Hospital

Petah Tikva, 4841492, Israel
Rambam Health Care Campus

Haifa, 3525408, Israel
Samsung Medical Center

Seoul, 06351, South Korea
Sarah Cannon Research Institute

London, W1G 6AD, United Kingdom
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Seoul National University Bundang Hospital

Seongnam-si, 13620, South Korea
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Shizuoka Cancer Center

Shizuoka, 411-8777, Japan
Southwestern Regional Medical Center

Tulsa, Oklahoma, 74133, United States
St. Joseph Heritage Healthcare

Santa Rosa, California, 95403, United States
Stanford Cancer Center

Palo Alto, California, 94304, United States
Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104, United States
Summit Medical Group

Florham Park, New Jersey, 07932, United States
The Finsen Centre National Hospital

Copenhagen, 02100, Denmark
The University of Arizona Cancer Center

Tucson, Arizona, 85724, United States
The West Clinic Pc

Germantown, Tennessee, 38138, United States
Tohoku University Hospital

Sendai, 980-8574, Japan
Umass Memorial Medical Center, Inc.

Worcester, Massachusetts, 01655, United States
Universitaetsklinikum in Tubingen

Tübingen, 72076, Germany
Universitatsklinikum Koln

Cologne, 50937, Germany
Universitatsspital Zurich

Zurich, 08091, Switzerland
University College London Hospitals (Uclh)

London, NW1 2PG, United Kingdom
University Hospital Grosshadern Munich

Munich, 81377, Germany
University Medical Center Freiburg

Freiburg im Breisgau, 79106, Germany
University Medical Centre Hamburg-Eppendorf, Centre of Oncology

Hamburg, 20246, Germany
University of Iowa

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Westwood, Kansas, 66205, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792, United States
Virginia Cancer Specialists, Pc

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates-Lake Wright

Norfolk, Virginia, 23502, United States
Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
West Virginia University Hospitals Inc

Morgantown, West Virginia, 26506, United States
Winthrop University Hospital

Mineola, New York, 11501, United States

Conditions

Explore the condition pages connected to this study.

SOLID TUMOR MALIGNANCY