New drug cocktail aims to shrink head and neck tumors before surgery

NCT ID NCT06161545

First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 24 times

Summary

This study tests whether a combination of two drugs (pembrolizumab and N-803) with or without special immune cells can help shrink head and neck cancers before surgery. About 40 adults with advanced, untreated head and neck cancer will receive the treatment for about 3 weeks before their planned tumor removal. The goal is to see if the treatment reduces the amount of live tumor tissue in the surgical sample.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.