Immunotherapy boosts standard chemo in AML trial

NCT ID NCT04214249

First seen Mar 20, 2026 · Last updated Apr 25, 2026 · Updated 2 times

Summary

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) achieve a deeper remission. About 49 adults with AML, including those whose leukemia arose from prior conditions, will receive either chemo alone or chemo plus pembrolizumab. The main goal is to see if the combination can eliminate more cancer cells that remain after initial treatment.

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Contacts and locations

Locations

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California, 92868, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Wake Forest Baptist Health - Wilkes Medical Center

    Wilkesboro, North Carolina, 28659, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Wake Forest University at Clemmons

    Clemmons, North Carolina, 27012, United States

  • Yale University

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.