New drug shows promise for stem cell transplant complication
NCT ID NCT05148299
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested a drug called pegcetacoplan in 12 adults who developed a serious blood clotting condition (TA-TMA) after a stem cell transplant. The goal was to see how the drug moves through the body, if it helps, and if it is safe. Researchers measured drug levels and markers of inflammation over 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pegcetacoplan
- What this could lead to
- If it works, this could point toward a treatment for a rare, serious complication of stem cell transplants.
- What could go wrong
- This is a very small, early pilot study with only 12 participants, so results may not apply to all patients. The drug may not improve outcomes or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ASST Monza - S. Gerardo Hospital
Monza, 20900, Italy
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Archet 1 hospital, Department of Clinical Hematology
Nice, 06200, France
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Big Metropolitan Hospital Niguarda Regional Health Authority
Milan, 20162, Italy
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CHU de Saint-Etienne
Saint-Priest-en-Jarez, 42270, France
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City of Hope
Duarte, California, 91010, United States
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General Hospital of Athens "Evangelismos"
Athens, 10676, Greece
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General Hospital of Thessaloniki "G. Papanikolaou", Hematology Department - BMT Unit
Thessaloniki, 57010, Greece
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Hospital San Giuseppe Moscati
Avellino, 83100, Italy
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Saint-Louis Hospital
Paris, Paris, 75010, France
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United Hospitals Villa Sofia Cervello
Palermo, 90146, Italy
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University General Hospital "Attikon"
Athens, Chaidari, 12462, Greece
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University Hospital Puerta de Hierro Majadahonda
Madrid, 28222, Spain
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University Polyclinic Foundation "Agostino Gemelli" - IRCCS
Roma, 00168, Italy