Can a new daily lens match the comfort of a proven one?
NCT ID NCT06995781
First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time
Summary
This trial is testing whether a new daily disposable contact lens, PEGAVISION G3, is as safe and effective as an existing lens (Clariti 1 day) for correcting nearsightedness. Adults with mild to moderate myopia will wear the lenses for three months, and researchers will measure vision sharpness and check for any eye problems. The goal is to see if the new lens provides clear, comfortable vision without causing harm.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PEGAVISION G3 silicone hydrogel daily disposable soft contact lenses
- What this could lead to
- If successful, this could provide a new daily disposable contact lens option that offers comparable vision correction and comfort for people with myopia.
- What could go wrong
- This is a relatively small, early-stage trial, and results may not reflect real-world use. As with any contact lens, there is a risk of eye irritation or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
69 people
The number who actually took part.
- Started
-
Jan 2025
- Finished
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Aug 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects must be at least 18 years of age on the date the ICF is signed and have the capacity to provide voluntary informed consent. 2. Subjects must be myopic and require lens correction from -1.00 to -8.00 Diopter (D) with ≤ 1.00 D astigmatism in each eye. 3. Subjects must be correctable through spherocylindrical refraction to Log Mar 0.1 or better in each eye. 4. Subjects must be adapted to soft contact lens wearers. 5. Subjects agree to follow the protocol and are willing to wear their study lenses for at least 8 hours per day at least 5 days per week on a daily disposable wear basis during the study. Exclusion Criteria: 1. Subjects who exhibit allergies to contact lens materials, contact lens packaging solutions, or possess a history of allergies that contraindicate conventional contact lens wear. 2. Subjects live in environments unsuitable for soft lens wear (like areas with dust, chemicals, aerosols). 3. Subjects presenting with active ocular conditions. These conditions include, but are not limited to, uveitis, corneal hypoesthesia, corneal epithelial defect, severe dry eye, lacrimal duct defect, glaucoma, cornea \[infiltrates\], conjunctiva, lids, and intraocular infection or inflammation of an allergic, bacterial, or viral etiology. 4. Use of systemic medications that are known to interfere with contact lenses wear at the investigator's discretion. 5. Currently pregnant (to the best of the Subject's knowledge), lactating or planning a pregnancy within the next 3 months 6. Any active participation in any contact lens or lens care product clinical trial within fourteen days prior to this study. 7. The presence of clinically significant (grade 3 or 4) anterior segment abnormalities; inflammations such as iritis; or any infection of the eye, lids, or associated structures. 8. Subject has a known history of corneal hypoesthesia (reduced corneal sensitivity), corneal ulcer, corneal infiltrates or fungal infections. 9. Subject has a history of papillary conjunctivitis that has interfered with contact lens wear. 10. Subject has a history of herpetic keratitis retinal detachment or irregular cornea. 11. Subject has a history of recurrent eye or eyelid infections, adverse effects associated with your contact lens wear, intolerance or an unusual response to your contact lens wear. 12. The Subject currently has pathological dry eye (tear break-up time ≤ 5 seconds). 13. Subjects who have undergone or plan to undergo corneal or intraocular surgery during the study period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.