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Fusing nerves with a polymer: a new hope for hand injury recovery?

NCT ID NCT03236064

Cure Sponsor: WellSpan Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This early-stage trial tests whether a substance called polyethylene glycol (PEG 3350) can improve nerve repair after a severe cut to nerves in the hand, wrist, or forearm. The goal is to see if applying PEG during surgery helps nerves regrow faster and more completely than standard repair techniques. The study involves a small group of adults with isolated nerve injuries, and it will measure how well nerve function returns and whether the procedure is safe.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Polyethylene glycol (PEG 3350), a substance applied during nerve repair surgery to help fuse severed nerve ends.
What this could lead to
If successful, this could lead to a new technique that speeds up and improves recovery after nerve injuries, potentially restoring more hand function than current surgery alone.
What could go wrong
This is a very early, small trial (only 4 participants), so results may not apply broadly. There are also unknown risks, and the procedure may not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

4 people

The number who actually took part.

Started

May 2016

Finished

Nov 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Isolated nerve transections of the digits, forearm, wrist, and palm will be included. * Class III nerve injury (Sunderland's 4th or 5th degree injury) * Nerve injuries that can be prepared using minimal or acceptable tension (according to surgeon discretion). * Pregnant and breastfeeding women cannot participate because of possible unknown and unpredictable risks to the unborn child. * Injuries beyond 24 hours will be excluded

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Injury of other nerves at wrist and hand level of unspecified arm, initial encounter

Contacts and locations

Locations

  • WellSpanYork Hospital

    York, Pennsylvania, 17405, United States