New hope for hard-to-treat prostate cancer: immune-boosting drug plus chemo tested in large trial

NCT ID NCT07225946

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Nov 10, 2025 · Last updated May 08, 2026 · Updated 23 times

Summary

This study tests whether adding pasritamig (a drug that helps the immune system attack cancer cells) to standard chemotherapy (docetaxel) can delay cancer growth in men with metastatic castration-resistant prostate cancer. About 800 participants will be randomly assigned to receive either the combination or chemotherapy alone. The main goal is to see how long the cancer stays under control based on scans.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AZ Maria Middelares
RECRUITING

Ghent, 9000, Belgium
Ankara University Medical Faculty
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Arizona Clinical Trials
RECRUITING

Chandler, Arizona, 85225, United States
Arkansas Urology
RECRUITING

Little Rock, Arkansas, 72211, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Avera Medical Group
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Beatson West Of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
Beijing Luhe Hospital, Capital Medical University
RECRUITING

Beijing, 101100, China
CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia
RECRUITING

Santo André, 09060 870, Brazil
CHC MontLegia
RECRUITING

Liège, 4000, Belgium
CHU de Quebec Universite Laval
RECRUITING

Québec, Quebec, G1R 2J6, Canada
Cancer Center of Kansas Heritage Plaza Medical Building
RECRUITING

Wichita, Kansas, 67214, United States
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Centre Oscar Lambret
RECRUITING

Lille, 59000, France
Centre de Recherche du CHUM
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
China Medical University Hospital
RECRUITING

Taichung, 404, Taiwan
Chu Helora Hospital La Louviere Site Jolimont
RECRUITING

La Louvière, 7100, Belgium
Colorado Clinical Research
RECRUITING

Lakewood, Colorado, 80228, United States
Duly Health and Care
RECRUITING

Lisle, Illinois, 60532, United States
ESHO Empresa De Servicos Hospitalares S A
RECRUITING

São Paulo, 01232 010, Brazil
East Jefferson General Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34232, United States
Fred Hutch Cancer Center Sloan Clinic 2
RECRUITING

Seattle, Washington, 98109, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Grand Valley Oncology
RECRUITING

Grand Junction, Colorado, 81505, United States
Groupe Hospitalo-Universitaire Carémeau
RECRUITING

Nîmes, 30900, France
Gulhane Training and Research Hospital
RECRUITING

Ankara, 06010, Turkey (Türkiye)
Gustave Roussy
RECRUITING

Villejuif, 94800, France
HealthPartners Cancer Center at Regions Hospital CRC East
RECRUITING

Saint Paul, Minnesota, 55101, United States
HealthPartners Frauenshuh Cancer Center CRC West
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Hopital Europeen Georges-Pompidou
RECRUITING

Paris, 75908, France
Hosp. Clinico Univ. Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hosp. Gral. Univ. J.M. Morales Meseguer
RECRUITING

Murcia, 30008, Spain
Hosp. Gral. Univ. Valencia
RECRUITING

Valencia, 46014, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Ana Nery Santa Cruz do Sul
RECRUITING

Santa Cruz do Sul, 96835-100, Brazil
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 50586, Malaysia
Hospital Umum Sarawak
RECRUITING

Kuching, 93586, Malaysia
Hospital Wanita dan Kanak-Kanak Sabah
RECRUITING

Kota Kinabalu, 88996, Malaysia
Houston Metro Urology
RECRUITING

Houston, Texas, 77027, United States
Icon Cancer Centre Kurralta Park
RECRUITING

Kurralta Park, 5037, Australia
Istanbul University Cerrahpasa tip Fakultesi
RECRUITING

Istanbul, 34096, Turkey (Türkiye)
Kaiser Permanente Southern California
RECRUITING

Riverside, California, 92505, United States
Kanazawa University Hospital
RECRUITING

Kanazawa, 920 8641, Japan
Kitasato University Hospital
RECRUITING

Sagamihara, 252-0375, Japan
Koc Universitesi Hastanesi
RECRUITING

Istanbul, 34147, Turkey (Türkiye)
Lancashire Teaching Hospitals NHS Foundation Trust Royal Preston Hospital
RECRUITING

Preston, PR2 9HT, United Kingdom
Lehigh Valley Hospital
RECRUITING

Allentown, Pennsylvania, 18103, United States
Liga Norte Riograndense Contra O Cancer
RECRUITING

Natal, 59062 000, Brazil
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan, 333, Taiwan
Medicana International Izmir
RECRUITING

Izmir, 35170, Turkey (Türkiye)
MidLantic Urology
RECRUITING

Bala-Cynwyd, Pennsylvania, 19004, United States
NAIC Nair Antunes Instituto do Cancer
RECRUITING

Bauru, 17033-495, Brazil
NHO Revive Research Institute, LLC
RECRUITING

Lincoln, Nebraska, 68506, United States
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, 210009, China
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
Oregon Urology Institute
RECRUITING

Springfield, Oregon, 97477, United States
Pan American Center for Oncology Trials LLC
RECRUITING

San Juan, 935, Puerto Rico
Penn State Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, 3000, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, 4102, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Profound Research LLC at Cancer and Leukemia Center
RECRUITING

Sterling Heights, Michigan, 48314, United States
Providence Saint John s Health Center
RECRUITING

Santa Monica, California, 90404, United States
Rocky Mountain Cancer Centers
RECRUITING

Aurora, Colorado, 80012, United States
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310009, China
St Bartholomews Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
Sun Yat Sen University Cancer Center
RECRUITING

Guangzhou, 510060, China
Sydney Adventist Hospital
RECRUITING

Wahroonga, 2076, Australia
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Tennessee Cancer Specialists
RECRUITING

Knoxville, Tennessee, 37909, United States
Texas Oncology 1
RECRUITING

Sugar Land, Texas, 77479, United States
The Catholic University of Korea Seoul St Marys Hospital
RECRUITING

Seoul, 06591, South Korea
The Central Hospital of Wuhan
RECRUITING

Wuhan, 430014, China
The First Affiliated Hospital of Xian Jiaotong University
RECRUITING

Xi'an, 710061, China
The Newcastle upon Tyne Hospitals NHS Trust - Freeman Hospit
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marsden NHS Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The Second Hospital Of Tianjin Medical University
RECRUITING

Tianjin, 300211, China
The Third People's Hospital of Chengdu
RECRUITING

Chengdu, 610014, China
Tungs' Taichung MetroHarbor Hospital
RECRUITING

Taichung, 435, Taiwan
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, 59100, Malaysia
University Of California San Diego
RECRUITING

La Jolla, California, 92037, United States
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
West China Hospital Sichuan University
RECRUITING

Chengdu, 610041, China
Yokohama City University Medical Center
RECRUITING

Yokohama, 232 0024, Japan
ZAS Augustinus
RECRUITING

Antwerp, 2610, Belgium

Conditions

Explore the condition pages connected to this study.

PROSTATIC NEOPLASMS, CASTRATION-RESISTANT