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New hope for Post-Surgery sugar crashes: pasireotide under study

NCT ID NCT05928390

Ongoing Disease control Sponsor: RECORDATI GROUP Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This phase 2 trial tests the drug pasireotide in 93 adults who experience severe low blood sugar after weight-loss surgery. Participants receive either the drug or a placebo for 12 weeks, then all can receive the drug for 36 more weeks. The goal is to see if pasireotide can stabilize blood sugar levels and reduce dangerous sugar crashes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
pasireotide (injectable drug)
What this could lead to
If it works, this could offer a new treatment option to prevent dangerous low blood sugar episodes after weight-loss surgery.
What could go wrong
This is a mid-stage trial with only 93 people, so results may not apply to everyone. The drug may cause side effects or not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dumping syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-BARIATRIC HYPOGLYCEMIA

Contacts and locations

Locations

  • AP-HP Hopital Europeen Georges Pompidou, 20, rue Leblanc,

    Paris, 75015, France

  • Azienda Ospedale - Università Padova, Clinica Medica 3, Via Giustiniani, 2,

    Padova, 35128, Italy

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

    Palermo, Italy

  • Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, L.go Gemelli 8

    Rome, Italy

  • Guy's Hospital

    London, United Kingdom

  • HCL Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • Hammersmith Hospital

    London, W12 OHS, United Kingdom

  • Hopital Rangueil, Attachée de Recherche Clinique, Centre Investigation Clinique, CHU, Cedex 9, France

    Toulouse, 31059, France

  • Hospital Clinic Barcelona, Lipid Clinic End, Nutr. Service Hospital Clinic, C. Villarroel, 170,

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos, C/ Prof Martin Lagos s/n, Spain

    Madrid, 28040, Spain

  • Hospital Germans Trias i Pujol

    Barcelona, 08916, Spain

  • Hospital Universitari de Girona Dr. Josep Trueta

    Girona, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario Vall d'Hebron, Passeig Vall d´Hebron 119-129, Spain

    Barcelona, 08035, Spain

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola

    Bologna, 40138, Italy

  • Joslin Diabetes CenterJoslin Diabetes Center, One Joslin Place

    Boston, Massachusetts, 02215, United States

  • King's College Hospital NHS Foundation Trust, Denmark Hill, SE5 9RS

    London, EC1A 1AA, United Kingdom

  • Mayo Clinic - Rochester, 200 First Street, SW, 55905

    Rochester, Minnesota, 55905, United States

  • Montefiore Medical Center, 111 E 210th Street,

    The Bronx, New York, 10467, United States

  • NOLA Care

    Metairie, Louisiana, 70006, United States

  • North Bristol NHS Trust

    Bristol, BS10 5NB, United Kingdom

  • Northwestern University - Feinberg School of Medicine - Ann & Robert H. Lurie Children's Hospital of Chicago

    Chicago, Illinois, 60628, United States

  • Stanford University School of Medicine, Endocrinology, 800 Welch Road,

    Palo Alto, California, 94305, United States

  • Universitaire Ziekenhuizen Leuven, Department of Gastroenterology and Hepatology,Herestraat 49

    Leuven, 3000, Belgium

  • University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr,

    San Antonio, Texas, 78229, United States

  • University of Wisconsin Health W. E. Clinic END, 451 Junction Rd,

    Madison, Wisconsin, 53717, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37204, United States

  • Velocity Clinical Research - Annapolis

    Annapolis, Maryland, 21401, United States

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