Can an Anti-Inflammatory drug shield the brain after a bleeding stroke?

NCT ID NCT06579274

This trial is taking on new participants right now.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests whether parecoxib, an anti-inflammatory drug, can improve recovery in people hospitalized after a spontaneous subarachnoid hemorrhage (SAH) — a type of bleeding stroke. The study includes 112 adults aged 18-85 with SAH, who will receive either parecoxib or a placebo via injection. The goal is to see if reducing inflammation can lower the risk of neurological complications and lead to better outcomes, measured by the modified Rankin Scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Parecoxib (Dynastat), an anti-inflammatory painkiller given by injection
What this could lead to
If parecoxib reduces inflammation-related complications after a bleeding stroke, it could improve patients' recovery and long-term independence.
What could go wrong
This is an early-phase trial, so the drug may not improve outcomes. Parecoxib, like other anti-inflammatories, carries risks such as bleeding or kidney issues.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 112 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed informed consent * Age: 18-85 years * Weight\> 50 kg * Spontaneous SAH diagnosed on a native CT brain max. 48 hours after the first symptoms * Spontaneous SAH caused by rupture of the cerebral aneurysm confirmed on DSA or CT angiography (Fisher grade 1 to 4) OR Spontaneous SAH without a source on CT AG, DSA or MRI with Fisher grade 3 and 4 * For women capable of becoming pregnant (see definitions from the CTFG guideline for contraception): use of the following highly reliable contraceptive method within 3 months after the end of the study: adherence to sexual abstinence or contraception containing progesterone with inhibition of ovulation (oral administration, injection) or non-hormonal intrauterine device or hormonal or bilateral tubal occlusion or partner vasectomy. Males: adherence to sexual abstinence or use of an adequate contraceptive method (i.e. condom) in case of sexual intercourse within 3 months after the end of the study. Exclusion Criteria: * Symptoms of SAH without the finding of blood on the initial native CT scan of the brain * SAH from a cause other than a ruptured aneurysm, e.g. A-V malformation, traumatic SAH * Pregnancy and breastfeeding (pregnancy test) * Known hypersensitivity to the components of the product * Allergic reaction to the active substance or sulfonamides in the anamnesis * Concomitant treatment with other non-steroidal anti-inflammatory drugs, aspirin or corticosteroids (at least five half-lives before administration of the medicinal product under investigation) * Severe hepatic insufficiency (serum albumin level \<25 g/l or Child-Pugh score less than 10). * Active peptic ulcer or bleeding from the gastrointestinal tract in the anamnesis * Inflammatory bowel disease in the anamnesis * Congestive heart failure (NYHA II-IV) in history. * Proven ischemic heart disease, peripheral arterial insufficiency. * Participation in another clinical study (a gap of at least five half-lives before administration of the medicinal product under investigation).

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Masarykovy nemocnice v Ústí nad Labem, o.z.

    RECRUITING

    Ústí nad Labem, 401 13, Czechia

  • St. Anne's University Hospital Brno

    RECRUITING

    Brno, Czech Republic, 602 00, Czechia

  • University Hospital Olomouc

    RECRUITING

    Olomouc, 779 00, Czechia

  • University Hospital Ostrava

    RECRUITING

    Ostrava, 708 52, Czechia

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