New combo therapy aims to shrink pancreatic tumors before surgery

NCT ID NCT06048484

First seen Feb 28, 2026 · Last updated May 10, 2026 · Updated 8 times

Summary

This study tests whether adding drugs that block the tumor's ability to hide from the immune system can make radiation therapy more effective for people with advanced pancreatic cancer. About 60 participants will receive standard radiation plus an immunotherapy drug, with or without two additional drugs that target the tumor's defenses. The goal is to see if these combinations increase immune cell activity in the tumor and improve surgical outcomes.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

    Contact Email: •••••@•••••

  • Northwell Health R.J. Zuckerberg Cancer Center

    RECRUITING

    Lake Success, New York, 11042, United States

    Contact Email: •••••@•••••

    Contact

  • UNC Hospitals, The University of North Carolina at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

    Contact Phone: •••-•••-••••

  • University of Pennsylvania, Abramson Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.