One pill vs. three: new hope for easier PAH treatment

NCT ID NCT03904693

Summary

This study tested if a single pill combining two existing PAH medications (macitentan and tadalafil) works better and is easier for patients than taking the two medications separately. It involved 187 adults with PAH who were randomly assigned to take either the combination pill or one of the single drugs for 16 weeks. The goal was to see if the simpler, one-pill approach improves blood flow in the lungs, walking ability, and symptoms compared to standard therapy.

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Contacts and locations

Locations

  • Abdullah, IA

    Durban, 4001, South Africa

  • Alberta Health Services

    Calgary, Alberta, T1Y 6J4, Canada

  • Altay Regional Cardiological Dispensary

    Barnaul, 656055, Russia

  • Ankara University Medical Faculty

    Ankara, 6500, Turkey (Türkiye)

  • Azienda Ospedaliera San Gerardo

    Monza, 20090, Italy

  • Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari

    Bari, 70124, Italy

  • Baylor Scott White - Plano

    Plano, Texas, 75093, United States

  • Beijing Anzhen Hospital

    Beijing, 100029, China

  • Bursa Yuksek Ihtisas Training and Research Hospital

    Bursa, 16310, Turkey (Türkiye)

  • Cardiologia c/o Spedali Civili

    Brescia, 25123, Italy

  • Chang-Gung Memorial Hospital, LinKou Branch

    Taoyuan District, 333, Taiwan

  • Chiba University Hospital

    Chiba, 260 8677, Japan

  • Core Research Group

    Milton, 4064, Australia

  • Cukurova University Medical Faculty

    Adana, 01790, Turkey (Türkiye)

  • Dokuz Eylul University Hospital

    Izmir, 35340, Turkey (Türkiye)

  • Dr Kalla

    Lenasia, 1820, South Africa

  • ECZ Otwock Klinika Kardiologii Klinika Krazenia Plucnego Chorob Zakrzepowo Zatorowych i Kardiologii

    Otwock, 05-400, Poland

  • Ege University School of Medicine

    Izmir, 35100, Turkey (Türkiye)

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Fukushima Medical University Hospital

    Fukushima, 960 1295, Japan

  • Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu)

    Botucatu, 18618-686, Brazil

  • GCM SUM I Oddzial Kardiologii

    Katowice, 40 635, Poland

  • GU Moscow Regional Research Clinical Institute n.a. M.F.Vla

    Moscva, 129090, Russia

  • General University Hospital II.department of Internal Medicine-cardiology and angiology

    Prague, 128 08, Czechia

  • Gottsegen György Országos Kardiológiai Intézet, Felnőtt kardiológiai osztály

    Budapest, 1096, Hungary

  • Gunma University Hospital

    Gunma, 371-0034, Japan

  • Hacettepe University Medical Faculty

    Ankara, 6100, Turkey (Türkiye)

  • Hokkaido University Hospital

    Sapporo, 060-8648, Japan

  • Hosp Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hosp Clinico Univ de Salamanca

    Salamanca, 37007, Spain

  • Hosp Univ Fund Jimenez Diaz

    Madrid, 28040, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 8035, Spain

  • Hosp. Gral. Univ. Valencia

    Valencia, 46014, Spain

  • Hosp. Univ. La Paz

    Madrid, 28046, Spain

  • Hosp. Univ. Marques de Valdecilla

    Santander, 39011, Spain

  • Hosp. Univ. Ramon Y Cajal

    Madrid, 28034, Spain

  • Hosp. Virgen de La Salud

    Toledo, 45004, Spain

  • Hospital Das Clinicas Da Faculdade De Medicina Da USP

    São Paulo, 05403-000, Brazil

  • Hospital das Clinicas de Porto Alegre

    Porto Alegre, 90035-007, Brazil

  • IRCCS Policlinico San Matteo, Università degli studi di Pavi

    Pavia, 27100, Italy

  • Institut Jantung Negara (National Heart Institute)

    Kuala Lumpur, 50400, Malaysia

  • Instituto Nacional de Cardiologia Dr. Ignacio Chavez

    México, 14080, Mexico

  • Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa

    Belo Horizonte, 30441-070, Brazil

  • Irmandade Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, 90035-074, Brazil

  • Istanbul University - Cerrahpasa Cardiology Institution

    Istanbul, 34096, Turkey (Türkiye)

  • Istanbul University Cerrahpasa Medical Faculty

    Istanbul, 34096, Turkey (Türkiye)

  • Jiangsu Province Hospital

    Nanjing, China

  • Juntendo University Hospital

    Tokyo, 113-8431, Japan

  • Kagoshima University Hospital

    Kagoshima, 890-8544, Japan

  • Kanazawa University Hospital

    Kanazawa, 920 8641, Japan

  • Kaohsiung Veterans General Hospital

    Kaohsiung City, 813, Taiwan

  • Kardiologische Praxis Papenburg

    Papenburg, 26871, Germany

  • Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi

    Kartal Istanbul, 34865, Turkey (Türkiye)

  • Klinika Kardiologii Z Oddzialem Intensywnego Nadzoru Kardiologicznego UM W Bialymstoku

    Bialystok, 15 276, Poland

  • Klinikum Würzburg Mitte gGmbH Standort Missioklinik

    Würzburg, 97074, Germany

  • Kobe University Hospital

    Kobe, 650 0017, Japan

  • Konya Selcuk University Medical Faculty

    Konya, 42131, Turkey (Türkiye)

  • Kumamoto University Hospital

    Kumamoto, 860-8556, Japan

  • Kure Kyosai Hospital

    Hiroshima, 737-8505, Japan

  • Kurume University Hospital

    Kurume, 830-0011, Japan

  • Kyorin University Hospital

    Mitaka, 181-8611, Japan

  • Kyoto University Hospital

    Kyoto, 606 8507, Japan

  • Kyushu University Hospital

    Fukuoka, 812 8582, Japan

  • Legacy Hospital

    Portland, Oregon, 97210, United States

  • London Health Sciences Centre

    London, Ontario, N6A 5W9, Canada

  • Mackay Memorial Hospital

    Taipei, 10449, Taiwan

  • Marmara University Medical Faculty

    Istanbul, 34899, Turkey (Türkiye)

  • Medical College of Wisconsin Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Mersin University Medical Faculty

    Mersin, 33110, Turkey (Türkiye)

  • Mie University Hospital

    Tsu, 514 8507, Japan

  • Minneapolis Heart Institute Foundation

    Minneapolis, Minnesota, 55407, United States

  • Nagasaki University Hospital

    Nagasaki, 852-8501, Japan

  • National Cerebral and Cardiovascular Center

    Suita-Shi, 564-8565, Japan

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Heart Hospital

    Sofia, 1309, Bulgaria

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192, Japan

  • National Medical Research Center of Cardiology of MoH of Russian Federation

    Moscow, 121552, Russia

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • National medical Research Center n.a. V.A.Almazov of MoH of Russian Federation

    Saint Petersburg, 197341, Russia

  • Norton Healthcare

    Louisville, Kentucky, 40202-1332, United States

  • OSF HealthCare Cardiovascular Institute

    Peoria, Illinois, 61614, United States

  • Oddzial Kardiologii Wojewodzki Szpital Specjalistyczny im W Bieganskiego

    Lodz, 91 347, Poland

  • Okayama University Hospital

    Okayama, 700 8558, Japan

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Ospedale San Francesco

    Nuoro, 08100, Italy

  • Pecsi Tudomanyegyetem Klinikai Kozpont

    Pécs, 7624, Hungary

  • Piedmont Healthcare

    Atlanta, Georgia, 30309, United States

  • Pitt County Memorial Hospital d/b/a Vidant Medical Center

    Greenville, North Carolina, 27835, United States

  • Policlinico Umberto I

    Roma, 00161, Italy

  • Providence Medical Foundation

    Fullerton, California, 92835, United States

  • Pulmonary Arterial Hypertension Clinic

    Hobart, 7000, Australia

  • Royal Adelaide Hospital

    Adelaide, 5000, Australia

  • SPDM - Associacao Paulista para o Desenvolvimento da Medicina - Hospital Sao Paulo

    São Paulo, 04024-002, Brazil

  • Samara Regional Clinical Cardiological Dispensary

    Samara, 443070, Russia

  • Sanford Health

    Fargo, North Dakota, 58122, United States

  • Sanford Health

    Sioux Falls, South Dakota, 57105, United States

  • Sapporo Medical University Hospital

    Sapporo, 060-8543, Japan

  • Sarawak Heart Center

    Kuching, 94300, Malaysia

  • Scientific and Research Institution of Cardiovascular Diseases Complex Problems

    Kemerovo, 650002, Russia

  • Secretaria da Saude do Estado do Ceara - Hospital Doutor Carlos Alberto Studart Gomes

    Fortaleza, 60840-285, Brazil

  • Semmelweis Egyetem,Pulmonológiai Klinika

    Budapest, 1083, Hungary

  • Shanghai Pulmonary Hospital

    Shanghai, 200433, China

  • Shinshu University Hospital

    Matsumoto, 390 8621, Japan

  • Sparrow Clinical Research Institute

    Lansing, Michigan, 48912, United States

  • St. Elizabeth Hospital Mercy Bon Secors

    Youngstown, Ohio, 44503, United States

  • Szegedi Tudomanyegyetem

    Szeged, 6725, Hungary

  • Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy, Klinika Kardiologii

    Bydgoszcz, 85-168, Poland

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, 510120, China

  • The First Affiliated Hospital of Xian Jiaotong University

    Xi'an, 710061, China

  • The General Hospital of Northern Theater Command

    Shenyang, 110000, China

  • The Second Xiangya Hospital of Central South Hospital

    Changsha, 410011, China

  • The University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27514, United States

  • The University of Tokyo Hospital

    Bunkyō City, 113-8655, Japan

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Thoraxklinik am Universitatsklinikum Heidelberg

    Heidelberg, 69126, Germany

  • Tianjin Medical University General Hospital

    Tianjin, 300052, China

  • Tohoku University Hospital

    Sendai, 980 8574, Japan

  • Tokai University Hospital

    Isehara, 259-1193, Japan

  • Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS

    Porto Alegre, 90610-000, Brazil

  • Unidad de Investigacion Clinica en Medicina S.C. (UDICEM)

    Monterrey, 64718, Mexico

  • Universidade Federal De Minas Gerais - Hospital das Clínicas

    Belo Horizonte, 30130-100, Brazil

  • Universidade Federal de Goias - Hospital das Clinicas da UFG

    Goiânia, 74605-020, Brazil

  • Universitaetsklinikum Giessen

    Giessen, 35392, Germany

  • Universitaetsklinikum Hamburg Eppendorf

    Hamburg, 20246, Germany

  • Universitaetsklinikum Regensburg

    Regensburg, 93053, Germany

  • Universitat Greifswald

    Greifswald, 17475, Germany

  • Universitatsklinikum Bonn

    Bonn, 53105, Germany

  • Universitatsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD

    Sofia, 1750, Bulgaria

  • University of Alberta

    Edmonton, Alberta, T6G 2G3, Canada

  • University of Cincinnati

    Cincinnati, Ohio, 45267, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Southern California

    Los Angeles, California, 90033, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Tsukuba Hospital

    Tsukuba, 305 8576, Japan

  • University of Wisconsin At Madison

    Madison, Wisconsin, 53792, United States

  • Uniwersytecki Szpital Kliniczny nr 2 PUM Klinika Kardiologii

    Szczecin, 70 111, Poland

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80 214, Poland

  • VA Sierra Nevada Health Care System

    Reno, Nevada, 89509, United States

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 1M9, Canada

  • WVU Health Sciences Center

    Morgantown, West Virginia, 26506, United States

  • Washington University School Of Medicine

    St Louis, Missouri, 63110, United States

  • WellStar Health System

    Marietta, Georgia, 30060, United States

  • Wojewodzki Szpital Specjalistyczny Oddzial Kardiologiczny

    Wroclaw, 51 124, Poland

  • Wojewodzki Szpital Specjalistyczny im. Stefana Kardynala Wyszynskiego SPZOZ, Oddzial Kardiologii

    Lublin, 20-718, Poland

Conditions

Explore the condition pages connected to this study.