One pill vs. three: new hope for easier PAH treatment
NCT ID NCT03904693
Summary
This study tested if a single pill combining two existing PAH medications (macitentan and tadalafil) works better and is easier for patients than taking the two medications separately. It involved 187 adults with PAH who were randomly assigned to take either the combination pill or one of the single drugs for 16 weeks. The goal was to see if the simpler, one-pill approach improves blood flow in the lungs, walking ability, and symptoms compared to standard therapy.
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Contacts and locations
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Locations
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Abdullah, IA
Durban, 4001, South Africa
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Alberta Health Services
Calgary, Alberta, T1Y 6J4, Canada
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Altay Regional Cardiological Dispensary
Barnaul, 656055, Russia
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Ankara University Medical Faculty
Ankara, 6500, Turkey (Türkiye)
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Azienda Ospedaliera San Gerardo
Monza, 20090, Italy
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Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari
Bari, 70124, Italy
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Baylor Scott White - Plano
Plano, Texas, 75093, United States
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Beijing Anzhen Hospital
Beijing, 100029, China
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Bursa Yuksek Ihtisas Training and Research Hospital
Bursa, 16310, Turkey (Türkiye)
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Cardiologia c/o Spedali Civili
Brescia, 25123, Italy
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Chang-Gung Memorial Hospital, LinKou Branch
Taoyuan District, 333, Taiwan
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Chiba University Hospital
Chiba, 260 8677, Japan
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Core Research Group
Milton, 4064, Australia
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Cukurova University Medical Faculty
Adana, 01790, Turkey (Türkiye)
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Dokuz Eylul University Hospital
Izmir, 35340, Turkey (Türkiye)
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Dr Kalla
Lenasia, 1820, South Africa
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ECZ Otwock Klinika Kardiologii Klinika Krazenia Plucnego Chorob Zakrzepowo Zatorowych i Kardiologii
Otwock, 05-400, Poland
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Ege University School of Medicine
Izmir, 35100, Turkey (Türkiye)
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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fukushima Medical University Hospital
Fukushima, 960 1295, Japan
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Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu)
Botucatu, 18618-686, Brazil
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GCM SUM I Oddzial Kardiologii
Katowice, 40 635, Poland
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GU Moscow Regional Research Clinical Institute n.a. M.F.Vla
Moscva, 129090, Russia
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General University Hospital II.department of Internal Medicine-cardiology and angiology
Prague, 128 08, Czechia
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Gottsegen György Országos Kardiológiai Intézet, Felnőtt kardiológiai osztály
Budapest, 1096, Hungary
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Gunma University Hospital
Gunma, 371-0034, Japan
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Hacettepe University Medical Faculty
Ankara, 6100, Turkey (Türkiye)
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Hokkaido University Hospital
Sapporo, 060-8648, Japan
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Hosp Clinic de Barcelona
Barcelona, 08036, Spain
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Hosp Clinico Univ de Salamanca
Salamanca, 37007, Spain
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Hosp Univ Fund Jimenez Diaz
Madrid, 28040, Spain
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Hosp Univ Vall D Hebron
Barcelona, 8035, Spain
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Hosp. Gral. Univ. Valencia
Valencia, 46014, Spain
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Hosp. Univ. La Paz
Madrid, 28046, Spain
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Hosp. Univ. Marques de Valdecilla
Santander, 39011, Spain
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Hosp. Univ. Ramon Y Cajal
Madrid, 28034, Spain
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Hosp. Virgen de La Salud
Toledo, 45004, Spain
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Hospital Das Clinicas Da Faculdade De Medicina Da USP
São Paulo, 05403-000, Brazil
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Hospital das Clinicas de Porto Alegre
Porto Alegre, 90035-007, Brazil
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IRCCS Policlinico San Matteo, Università degli studi di Pavi
Pavia, 27100, Italy
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Institut Jantung Negara (National Heart Institute)
Kuala Lumpur, 50400, Malaysia
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Instituto Nacional de Cardiologia Dr. Ignacio Chavez
México, 14080, Mexico
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Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa
Belo Horizonte, 30441-070, Brazil
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Irmandade Santa Casa de Misericordia de Porto Alegre
Porto Alegre, 90035-074, Brazil
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Istanbul University - Cerrahpasa Cardiology Institution
Istanbul, 34096, Turkey (Türkiye)
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Istanbul University Cerrahpasa Medical Faculty
Istanbul, 34096, Turkey (Türkiye)
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Jiangsu Province Hospital
Nanjing, China
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Juntendo University Hospital
Tokyo, 113-8431, Japan
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Kagoshima University Hospital
Kagoshima, 890-8544, Japan
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Kanazawa University Hospital
Kanazawa, 920 8641, Japan
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Kaohsiung Veterans General Hospital
Kaohsiung City, 813, Taiwan
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Kardiologische Praxis Papenburg
Papenburg, 26871, Germany
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Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi
Kartal Istanbul, 34865, Turkey (Türkiye)
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Klinika Kardiologii Z Oddzialem Intensywnego Nadzoru Kardiologicznego UM W Bialymstoku
Bialystok, 15 276, Poland
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Klinikum Würzburg Mitte gGmbH Standort Missioklinik
Würzburg, 97074, Germany
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Kobe University Hospital
Kobe, 650 0017, Japan
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Konya Selcuk University Medical Faculty
Konya, 42131, Turkey (Türkiye)
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Kumamoto University Hospital
Kumamoto, 860-8556, Japan
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Kure Kyosai Hospital
Hiroshima, 737-8505, Japan
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Kurume University Hospital
Kurume, 830-0011, Japan
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Kyorin University Hospital
Mitaka, 181-8611, Japan
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Kyoto University Hospital
Kyoto, 606 8507, Japan
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Kyushu University Hospital
Fukuoka, 812 8582, Japan
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Legacy Hospital
Portland, Oregon, 97210, United States
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London Health Sciences Centre
London, Ontario, N6A 5W9, Canada
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Mackay Memorial Hospital
Taipei, 10449, Taiwan
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Marmara University Medical Faculty
Istanbul, 34899, Turkey (Türkiye)
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Medical College of Wisconsin Froedtert Hospital
Milwaukee, Wisconsin, 53226, United States
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Mersin University Medical Faculty
Mersin, 33110, Turkey (Türkiye)
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Mie University Hospital
Tsu, 514 8507, Japan
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Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, 55407, United States
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Nagasaki University Hospital
Nagasaki, 852-8501, Japan
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National Cerebral and Cardiovascular Center
Suita-Shi, 564-8565, Japan
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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National Heart Hospital
Sofia, 1309, Bulgaria
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National Hospital Organization Okayama Medical Center
Okayama, 701-1192, Japan
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National Medical Research Center of Cardiology of MoH of Russian Federation
Moscow, 121552, Russia
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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National medical Research Center n.a. V.A.Almazov of MoH of Russian Federation
Saint Petersburg, 197341, Russia
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Norton Healthcare
Louisville, Kentucky, 40202-1332, United States
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OSF HealthCare Cardiovascular Institute
Peoria, Illinois, 61614, United States
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Oddzial Kardiologii Wojewodzki Szpital Specjalistyczny im W Bieganskiego
Lodz, 91 347, Poland
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Okayama University Hospital
Okayama, 700 8558, Japan
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Ospedale San Francesco
Nuoro, 08100, Italy
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Pecsi Tudomanyegyetem Klinikai Kozpont
Pécs, 7624, Hungary
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Piedmont Healthcare
Atlanta, Georgia, 30309, United States
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Pitt County Memorial Hospital d/b/a Vidant Medical Center
Greenville, North Carolina, 27835, United States
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Policlinico Umberto I
Roma, 00161, Italy
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Providence Medical Foundation
Fullerton, California, 92835, United States
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Pulmonary Arterial Hypertension Clinic
Hobart, 7000, Australia
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Royal Adelaide Hospital
Adelaide, 5000, Australia
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SPDM - Associacao Paulista para o Desenvolvimento da Medicina - Hospital Sao Paulo
São Paulo, 04024-002, Brazil
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Samara Regional Clinical Cardiological Dispensary
Samara, 443070, Russia
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Sanford Health
Fargo, North Dakota, 58122, United States
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Sanford Health
Sioux Falls, South Dakota, 57105, United States
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Sapporo Medical University Hospital
Sapporo, 060-8543, Japan
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Sarawak Heart Center
Kuching, 94300, Malaysia
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Scientific and Research Institution of Cardiovascular Diseases Complex Problems
Kemerovo, 650002, Russia
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Secretaria da Saude do Estado do Ceara - Hospital Doutor Carlos Alberto Studart Gomes
Fortaleza, 60840-285, Brazil
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Semmelweis Egyetem,Pulmonológiai Klinika
Budapest, 1083, Hungary
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Shanghai Pulmonary Hospital
Shanghai, 200433, China
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Shinshu University Hospital
Matsumoto, 390 8621, Japan
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Sparrow Clinical Research Institute
Lansing, Michigan, 48912, United States
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St. Elizabeth Hospital Mercy Bon Secors
Youngstown, Ohio, 44503, United States
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Szegedi Tudomanyegyetem
Szeged, 6725, Hungary
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Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy, Klinika Kardiologii
Bydgoszcz, 85-168, Poland
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Taipei Veterans General Hospital
Taipei, 112, Taiwan
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The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510120, China
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The First Affiliated Hospital of Xian Jiaotong University
Xi'an, 710061, China
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The General Hospital of Northern Theater Command
Shenyang, 110000, China
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The Second Xiangya Hospital of Central South Hospital
Changsha, 410011, China
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The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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The University of Tokyo Hospital
Bunkyō City, 113-8655, Japan
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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Thoraxklinik am Universitatsklinikum Heidelberg
Heidelberg, 69126, Germany
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Tianjin Medical University General Hospital
Tianjin, 300052, China
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Tohoku University Hospital
Sendai, 980 8574, Japan
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Tokai University Hospital
Isehara, 259-1193, Japan
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Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
Porto Alegre, 90610-000, Brazil
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Unidad de Investigacion Clinica en Medicina S.C. (UDICEM)
Monterrey, 64718, Mexico
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Universidade Federal De Minas Gerais - Hospital das Clínicas
Belo Horizonte, 30130-100, Brazil
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Universidade Federal de Goias - Hospital das Clinicas da UFG
Goiânia, 74605-020, Brazil
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Universitaetsklinikum Giessen
Giessen, 35392, Germany
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Universitaetsklinikum Hamburg Eppendorf
Hamburg, 20246, Germany
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Universitaetsklinikum Regensburg
Regensburg, 93053, Germany
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Universitat Greifswald
Greifswald, 17475, Germany
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Universitatsklinikum Bonn
Bonn, 53105, Germany
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Universitatsklinikum Carl Gustav Carus Dresden
Dresden, 01307, Germany
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University Hospital Kyoto Prefectural University of Medicine
Kyoto, 602-8566, Japan
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University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
Sofia, 1750, Bulgaria
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University of Alberta
Edmonton, Alberta, T6G 2G3, Canada
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University of Cincinnati
Cincinnati, Ohio, 45267, United States
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University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52242, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Southern California
Los Angeles, California, 90033, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Tsukuba Hospital
Tsukuba, 305 8576, Japan
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University of Wisconsin At Madison
Madison, Wisconsin, 53792, United States
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Uniwersytecki Szpital Kliniczny nr 2 PUM Klinika Kardiologii
Szczecin, 70 111, Poland
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Uniwersyteckie Centrum Kliniczne
Gdansk, 80 214, Poland
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VA Sierra Nevada Health Care System
Reno, Nevada, 89509, United States
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Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
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WVU Health Sciences Center
Morgantown, West Virginia, 26506, United States
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Washington University School Of Medicine
St Louis, Missouri, 63110, United States
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WellStar Health System
Marietta, Georgia, 30060, United States
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Wojewodzki Szpital Specjalistyczny Oddzial Kardiologiczny
Wroclaw, 51 124, Poland
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Wojewodzki Szpital Specjalistyczny im. Stefana Kardynala Wyszynskiego SPZOZ, Oddzial Kardiologii
Lublin, 20-718, Poland
Conditions
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