New hope for blood cancer patients with dangerous low platelets

NCT ID NCT03165734

Recruiting now Disease control Sponsor: Swedish Orphan Biovitrum Source: ClinicalTrials.gov ↗

Summary

This study is testing an investigational drug called pacritinib against standard care treatments for adults with myelofibrosis, a serious bone marrow cancer, who also have dangerously low platelet counts. The main goals are to see if pacritinib can reduce spleen size and ease disease symptoms better than current options. About 399 participants will be randomly assigned to receive either pacritinib or a standard treatment chosen by their doctor.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ASST Monza - Ospedale San Gerardo
RECRUITING

Monza, Italy
ASST Sette Laghi Hospital
RECRUITING

Varese, Italy
ASST Spedali Civili Brescia, Hematology Unit
RECRUITING

Brescia, Italy
Aktobe Medical Center, Department of Hematology
RECRUITING

Aktobe, Kazakhstan
Alfred Hospital, Malignant Hematology and Stem Cell Transplantation Service
RECRUITING

Melbourne, Victoria, Australia
All India Institute of Medical Sciences
RECRUITING

Dehradun, Uttarakhand, India
American Oncology Partners of Maryland, PA
COMPLETED

Bethesda, Maryland, 20817, United States
Andrzej Mielecki Independent Public Clinical Hospital of Medical University of Silesia in Katowice, Department of Hematology and Bone Marrow Transplantation
RECRUITING

Katowice, Poland
Azienda Ospedaliero-Universitaria Careggi
RECRUITING

Florence, Italy
Barts Health NHS Trust - The Royal London Hospital
RECRUITING

London, United Kingdom, E1 2ES, United Kingdom
Bashkiria State Medical University, Department of Internal Medicine
COMPLETED

Ufa, Russia
Beatson West of Scotland Cancer Centre
COMPLETED

Glasgow, United Kingdom, G12 0ZD, United Kingdom
CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque
RECRUITING

Pessac, 33604, France
CHU Hôpital Amiens Sud
COMPLETED

Amiens, France, 80054, France
CHU de Nimes - Hopital Universitaire Caremeau
RECRUITING

Nîmes, France, 30900, France
Cancer Institute "Giovanni Paolo II", IRCCS
RECRUITING

Bari, Italy
Cancer and Hematology Centers of Western Michigan
COMPLETED

Grand Rapids, Michigan, 49546, United States
Center for Hematology
RECRUITING

Astana, Kazakhstan
Center for Hematology
RECRUITING

Ust-Kamenogorsk, Kazakhstan
Centre Hospitalier Lyon-Sud
RECRUITING

Pierre-Bénite, France
Cetus Oncology Inc.
RECRUITING

Belo Horizonte, Minas Gerais, Brazil
Cherkasy Regional Oncology Dispensary of Cherkasy Oblast Council, Regional Treatment and Diagnostic Hematology Center, Department of Hematology
COMPLETED

Cherkasy, Ukraine
City Clinical Hospital #4" under Dnipro City Council
COMPLETED

Dnipro, Ukraine
City Clinical Hospital #40
COMPLETED

Moscow, Russia
City Clinical Hospital #7, Hematology Department
RECRUITING

Almaty, Kazakhstan
City Clinical Hospital n.a. V.V. Veresaev of the Moscow City Health
COMPLETED

Moscow, Russia
City Oncological Center
RECRUITING

Shymkent, Kazakhstan
City of Health and Science of Turin
RECRUITING

Turin, Italy
City of Hope
COMPLETED

Duarte, California, 91010, United States
Cleveland Clinic
COMPLETED

Cleveland, Ohio, 44106, United States
Cleveland Clinic Florida
COMPLETED

Weston, Florida, 33331, United States
Clinic UZI 4D, LLC
COMPLETED

Pyatigorsk, Russia
Clinical Center of Serbia, Clinic of Hematology
RECRUITING

Belgrade, Serbia
Clinical Center of Vojvodina, Clinic of Hematology
SUSPENDED

Novi Sad, Serbia
Clinical Hospital of the Federal University of Parana (HC - UFPR)
RECRUITING

Curitiba, Paraná, Brazil
Clinics Hospital, Federal University of Goias - (UFG)
RECRUITING

Goiânia, Goiás, Brazil
Coltea Clinical Hospital
RECRUITING

Bucharest, Romania
Columbia University Medical Center
COMPLETED

New York, New York, 10017, United States
Communal Non-profit enterprise "Regional Center of Oncology", Department of Hematology
COMPLETED

Kharkiv, Ukraine
Comprehensive Cancer Centers of Nevada- Twain Office
COMPLETED

Las Vegas, Nevada, 89169, United States
Duke University Hospital
COMPLETED

Durham, North Carolina, 27710, United States
Eastern Regional Health Authority
COMPLETED

St. John's, Newfoundland and Labrador, Canada
Ehime University Hospital
RECRUITING

Tōon, Japan
Fejer County St. Gyorgy University Teaching Hospital, Department of Internal Medicine I
RECRUITING

Székesfehérvár, Hungary
Fortis Memorial Research Institute(FMRI)
RECRUITING

Gurgaon, Haryana, India
Fred Hutchinson Cancer Research Center
COMPLETED

Seattle, Washington, 98109, United States
Frederic Chopin Provincial Teaching Hospital No. 1 in Rzeszow, Department of Hematology,
COMPLETED

Rzeszów, Poland
Fukushima Medical University Hospital
RECRUITING

Fukushima, Japan
Fundeni Clinical Institute
RECRUITING

Bucharest, Romania
Gauhati Medical College and Hospital
RECRUITING

Guwahati, Assam, India
George Washington University-Medical Faculty Associates
COMPLETED

Washington D.C., District of Columbia, 20037, United States
Georgetown University Hospital
COMPLETED

Washington D.C., District of Columbia, 20007, United States
Gloucestershire Royal Hospital
RECRUITING

Gloucester, United Kingdom
Grodno University Hospital
COMPLETED

Grodno, Belarus
Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital
RECRUITING

London, United Kingdom
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center, Department of Hematology,
RECRUITING

Jerusalem, Israel
Hematology Center
RECRUITING

Karaganda, Kazakhstan
Hospital "Infermi" of Rimini
COMPLETED

Rimini, Italy
Hospital Amaral Carvalho
RECRUITING

Jaú, São Paulo, Brazil
Hospital Clínic de Barcelona
RECRUITING

Barcelona, Spain
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, Brazil
Hospital Sao Rafael
RECRUITING

Salvador, Estado de Bahia, Brazil
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Spain
Hospital del Mar
COMPLETED

Barcelona, Spain
Humane Clinic / Atena Research Institute
RECRUITING

Mossoró, Rio Grande do Norte, Brazil
Hôpital Saint-Louis
RECRUITING

Paris, France
Icahn School of Medicine at Mount Sinai
COMPLETED

New York, New York, 10029, United States
Imperial College Healthcare NHS Trust - Hammersmith Hospital
RECRUITING

London, United Kingdom
Independent Public Teaching Hospital No.1 in Lublin, Department of Hematooncology, Bone Marrow Transplantation and Chemotherapy
RECRUITING

Lublin, Poland
Institute of Blood Pathology and Transfusion Medicine, Department of Hematology
COMPLETED

Lviv, Ukraine
Institute of Hematology and Transfusion Medicine, Teaching Department of Hematology
COMPLETED

Warsaw, Poland
Integrare Therapeutics
RECRUITING

Fortaleza, Ceará, Brazil
Integrated Oncology Center of Rio Grande do Sul - Mother of God Hospital
RECRUITING

Porto Alegre, Rio Grande do Sul, Brazil
JSC K. Eristavi National Center For Experimental and Clinical Surgery
RECRUITING

Tbilisi, Georgia
Jan Mikulicz Radecki University Hospital in Wroclaw, Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation
RECRUITING

Wroclaw, Poland
Jedrzej Sniadecki Specialist Hospital in Nowy Sacz, Department of Hematology
RECRUITING

Nowy Sącz, Poland
Jewish General Hospital; Clinical Research Unit
RECRUITING

Montreal, Quebec, Canada
Jewish Hospital Albert Einstein
RECRUITING

São Paulo, São Paulo, Brazil
Johns Hopkins University
COMPLETED

Baltimore, Maryland, 21287, United States
Juntendo University Hospital
RECRUITING

Tokyo, Japan
Kyiv City Clinical Hospital #9, Hematology Department #1
COMPLETED

Kyiv, Ukraine
Kyiv Regional Oncology Center, Department of Hematology,
COMPLETED

Kyiv, Ukraine
Kyungpook National University Hospital
RECRUITING

Daegu, South Korea
Kyushu University Hospital
RECRUITING

Fukuoka, Japan
LTD M.Zodelava's Hematology Center, Department of Hematology
COMPLETED

Tbilisi, Georgia
LTD S.Khechinashvili University Hospital
COMPLETED

Tbilisi, Georgia
La Conception Hospital
SUSPENDED

Marseille, France
Lady Davis Carmel Medical Center, Department of Hematology,
RECRUITING

Haifa, Israel
Limited Liability Company "City Doctor"
COMPLETED

Kyiv, Ukraine
Maggiore Polyclinic Hospital, Fondazione IRCCS Ca' Granda
RECRUITING

Milan, Italy
Malkhaz Katsiashvili Multiprofile Emergency Medicine Center LTD
COMPLETED

Tbilisi, Georgia
Maryland Oncology Hematology, PA- Columbia
COMPLETED

Columbia, Maryland, 21044, United States
Max Super Speciality Hospital Saket (A Unit of Max Healthcare Institute Limited)
RECRUITING

Delhi, India
Mayo Clinic Hospital
COMPLETED

Phoenix, Arizona, 85054, United States
Mays Cancer Center
COMPLETED

San Antonio, Texas, 78229, United States
Meenakshi Mission Hospital And Research Centre (MMHRC)
RECRUITING

Madurai, Tamil Nadu, India
Meir Medical Center, Hematology Institute and Blood Bank
RECRUITING

Kfar Saba, Israel
Memorial Sloan -Kettering Cancer Center
COMPLETED

New York, New York, 10065, United States
Michigan Medicine Hematology Clinic-Rogel Cancer Center
COMPLETED

Ann Arbor, Michigan, 48109, United States
Mie University Hospital
RECRUITING

Tsu, Japan
Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology
RECRUITING

Minsk, Belarus
Morales Meseguer University General Hospital, Department of Hematology and Hemotherapy
SUSPENDED

Murcia, Spain
Multiprofile Hospital for Active Treatment "Sveta Marina"
COMPLETED

Varna, Bulgaria
Multiprofile Hospital for Active Treatment - Sofia, part of Military Medical Academy
RECRUITING

Sofia, Bulgaria
Nasz Lekarz Medical Outpatient Clinics Slawomir Jeka
COMPLETED

Torun, Poland
National Research Oncology, Oncohematology Center
RECRUITING

Astana, Kazakhstan
Netaji Subhash Chandra Bose Cancer Research Institute
RECRUITING

Kolkata, West Bengal, India
Nicolaus Copernicus Provincial Multispecialty Oncology and Traumatology Center in Lodz
RECRUITING

Lodz, Poland
Nippon Medical School Hospital
RECRUITING

Tokyo, Japan
Nirmal Hospital Pvt Ltd
RECRUITING

Surat, Gujarat, India
Northwestern Memorial Hospital
COMPLETED

Chicago, Illinois, 60611, United States
Nova Scotia Health Authority, Centre for Clinical Research
RECRUITING

Halifax, Nova Scotia, Canada
Ochsner Medical Center
COMPLETED

New Orleans, Louisiana, 70121, United States
Onco Card Srl
RECRUITING

Brasov, Romania
Oregon Health and Science University
COMPLETED

Portland, Oregon, 97239-3098, United States
Oxford University Hospitals NHS Trust - Churchill Hospital
RECRUITING

Oxford, United Kingdom
Poltava M.V. Sklifosovskyi Regional Clinical Hospital under Poltava Regional Council, Department of Hematology
COMPLETED

Poltava, Ukraine
Polyclinic S. Orsola-Malpighi
RECRUITING

Bologna, Italy
Polyclinic San Matteo, IRCCS
COMPLETED

Pavia, Italy
Postgraduate Institute of Medical Education and Research (PGIMER)
RECRUITING

Chandigarh, Chandigarh, India
Pratia Oncology Katowice
RECRUITING

Katowice, Poland
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, Canada
Prof. Dr. Ion Chiricuta" Institute of Oncology
RECRUITING

Cluj-Napoca, Romania
Providence Hematology - Vancouver
RECRUITING

Vancouver, British Columbia, Canada
Pusan National University Hospital
RECRUITING

Busan, South Korea
Rabin Medical Center, Clinic for Myeloproliferative Disorders
COMPLETED

Petah Tikva, Israel
Regional Cancer Care Associates LLC - CCBD Division
COMPLETED

Bethesda, Maryland, 20817, United States
Republican Research Center for Radiation Medicine and Human Ecology
RECRUITING

Homyel, Belarus
Research Institute of Hematology and Transfusiology
COMPLETED

Saint Petersburg, Russia
Rocky Mountain Cancer Centers (US Oncology/McKesson)
COMPLETED

Boulder, Colorado, 80303, United States
Royal Hallamshire Hospital, Department of Hematology
COMPLETED

Sheffield, South Yorkshire, United Kingdom
Rush University Medical Center
COMPLETED

Chicago, Illinois, 60612, United States
S.M. Kirov Military Medical Academy, Department and Clinic for Intermediate-Level Training in Internal Medicine, Hematology Division
COMPLETED

Saint Petersburg, Russia
S.P. Botkin City Clinical Hospital
COMPLETED

Moscow, Russia
Sahyadri Super Speciality Hospital
RECRUITING

Pune, Maharashtra, India
Saint Agnes Hospital
COMPLETED

Baltimore, Maryland, 21229, United States
Saint Lucas Hospital of Copacabana
RECRUITING

Rio de Janeiro, Rio de Janeiro, Brazil
Samaritano Hospital
RECRUITING

São Paulo, São Paulo, Brazil
Samsung Medical Center
RECRUITING

Seoul, South Korea
Santa Catarina Health Research and Education Center (CEPEN)
RECRUITING

Florianópolis, Santa Catarina, Brazil
Santa Maria della Misericordia University Hospital of Udine
RECRUITING

Udine, Italy
Sao Paulo University Clinical Hospital
RECRUITING

São Paulo, São Paulo, Brazil
Scientific Institute of Romagna for the Study and Treatment of Cancer (IRST), IRCCS
RECRUITING

Forlì, Italy
Semmelweis University SE ÁOK I. sz. Belgyógyászati Klinika
COMPLETED

Budapest, Hungary
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Severance Hospital
RECRUITING

Seoul, South Korea, 3722, South Korea
Shri Ram Cancer Centre, Mahatma Gandhi Medical College & Hospital
RECRUITING

Jaipur, Rajasthan, India
Somogy Megyei Kaposi Mór Oktató Kórház
RECRUITING

Kaposvár, Hungary
Specialized Hospital for Active Treatment of Hematological Diseases
RECRUITING

Sofia, Bulgaria
St. John's Medical College Hospital
RECRUITING

Bengaluru, India
State University of Campinas (UNICAMP) - Hemocenter
RECRUITING

Campinas, São Paulo, Brazil
Szabolcs-Szatmar-Bereg County Hospitals and University Teaching Hospital, Department of Hematology
COMPLETED

Nyíregyháza, Hungary
Tata Medical Center
RECRUITING

Kolkata, West Bengal, India
Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC
RECRUITING

Tbilisi, Georgia
Texas Oncology- San Antonio
COMPLETED

San Antonio, Texas, 78240, United States
The Catholic University of Korea, St. Mary's Hospital
RECRUITING

Seoul, South Korea
The James Cancer Hospital and Solove Research Institute
COMPLETED

Columbus, Ohio, 43210, United States
The Perth Blood Institute
SUSPENDED

Perth, Western Australia, Australia
The Sarah Cannon Research Institute-Tennessee Oncology
COMPLETED

Nashville, Tennessee, 37203, United States
The Tel Aviv Sourasky Medical Center, Department of Internal Medicine
COMPLETED

Tel Aviv, Israel
The University of Chicago Medical Center
COMPLETED

Chicago, Illinois, 60637, United States
The University of Texas MD Anderson Cancer Center
COMPLETED

Houston, Texas, 77030, United States
Tohoku University Hospital
RECRUITING

Miyagi, Japan
Tokyo Medical University Hospital
RECRUITING

Tokyo, Japan
Tom Baker Cancer Center, Internal Medicine/Hematology
COMPLETED

Calgary, Alberta, Canada
UCLA David Geffen School of Medicine
COMPLETED

Los Angeles, California, 90095, United States
UPMC Hillman Cancer Center
COMPLETED

Pittsburgh, Pennsylvania, 15232, United States
USC Norris Comprehensive Cancer Center
COMPLETED

Los Angeles, California, 90033, United States
Umberto I Polyclinic of Rome
RECRUITING

Rome, Italy
United Hospitals Villa Sofia Cervello
RECRUITING

Palermo, Italy
University Clinical Center in Gdansk
RECRUITING

Gdansk, Poland
University Clinical Center of Sarajevo
RECRUITING

Sarajevo, Bosnia and Herzegovina
University Clinical Centre of the Republic of Srpska
RECRUITING

Banja Luka, Bosnia and Herzegovina
University Clinical Hospital of Salamanca, Department of Hematology
RECRUITING

Salamanca, Spain
University Clinical Hospital of Valencia, Department of Hematology and Medical Oncology
COMPLETED

Valencia, Spain
University Hospital "Federico II"
RECRUITING

Naples, Italy
University Hospital "Maggiore della Carita" of Novara
RECRUITING

Novara, Italy
University Hospital 12 de Octubre, Department of Hematology
RECRUITING

Madrid, Spain
University Hospital Brno
RECRUITING

Brno, Czechia
University Hospital Center of Poitiers
RECRUITING

Poitiers, France
University Hospital Kralovske Vinohrady, Clinic of Internal Hematology
RECRUITING

Prague, Czechia
University Hospital Olomouc
RECRUITING

Olomouc, Czechia
University Hospital Plzen
RECRUITING

Pilsen, Czechia
University Hospital Vall d'Hebron
SUSPENDED

Barcelona, Spain
University Hospital Virgen del Rocio (HUVR)
RECRUITING

Seville, Spain
University Hospital in Krakow
RECRUITING

Krakow, Poland
University Multiprofile Hospital for Active Treatment "Dr. Georgi Stranski"
RECRUITING

Pleven, Bulgaria
University Multiprofile Hospital for Active Treatment "Sveti Georgi", Plovdiv
RECRUITING

Plovdiv, Bulgaria
University Polyclinic Foundation "Agostino Gemelli"
RECRUITING

Rome, Italy
University Teaching Hospital in Bialystok
RECRUITING

Bialystok, Poland
University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer Center
COMPLETED

Birmingham, Alabama, 35294, United States
University of Alberta
COMPLETED

Edmonton, Alberta, Canada
University of Colorado Cancer Center
COMPLETED

Aurora, Colorado, 80045, United States
University of Debrecen Clinical Center (Debreceni Egyetem Klinikai Központ)
COMPLETED

Debrecen, Hungary
University of Kansas Cancer Center and Medical Pavilion
COMPLETED

Westwood, Kansas, 66205, United States
University of Miyazaki Hospital
RECRUITING

Miyazaki, Japan
University of Rochester
COMPLETED

Rochester, New York, 14642, United States
University of Utah - Huntsman Cancer Institute
COMPLETED

Salt Lake City, Utah, 84112, United States
University of Yamanashi Hospital
RECRUITING

Chūō, Japan
V.A. Almazov North-West Federal Medical Research Center, Institute of Oncology and Hematology, Scientific Department of Clinical Oncology
COMPLETED

Saint Petersburg, Russia
Volgograd Regional Clinical Oncology Center
COMPLETED

Volgograd, Russia
Washington University School of Medicine-Siteman Cancer Center
COMPLETED

St Louis, Missouri, 63110, United States
Weill Cornell Medical College
COMPLETED

New York, New York, 10021, United States
Westmead Hospital
RECRUITING

Sydney, New South Wales, Australia
Yale School of Medicine
COMPLETED

New Haven, Connecticut, 06510, United States
Yashoda Hospitals
RECRUITING

Hyderabad, Telangana, India

Conditions

Explore the condition pages connected to this study.

POST-ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS POST-POLYCYTHEMIA VERA MYELOFIBROSIS PRIMARY MYELOFIBROSIS