New hope for hard-to-treat ovarian cancer: experimental drug targets key protein

NCT ID NCT07023627

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 25 times

Summary

This study tests an experimental drug called INCB123667 in people with a type of ovarian cancer that no longer responds to platinum chemotherapy and has high levels of a protein called cyclin E1. About 160 participants will receive the drug to see if it can shrink tumors or slow the disease. The goal is to find a new treatment option for this difficult-to-treat cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Asplundh Cancer Pavilion - Thomas Jefferson
WITHDRAWN

Willow Grove, Pennsylvania, 19090, United States
Az Groeninge
RECRUITING

Kortrijk, 08500, Belgium
Blacktown Cancer & Haematology Centre-Blacktown Hospital
NOT_YET_RECRUITING

Blacktown, New South Wales, 02148, Australia
Burnside War Memorial Hospital - the Brian Fricker Oncology Centre
NOT_YET_RECRUITING

Adelaide, South Australia, 05065, Australia
Cancer Research Sa (Crsa)
RECRUITING

Adelaide, 05000, Australia
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24016-4962, United States
Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) - Centre Du Cancer Lausanne-Batiment Hospit
NOT_YET_RECRUITING

Lausanne, 01011, Switzerland
Chu Liege
NOT_YET_RECRUITING

Liège, 04000, Belgium
Clinica Universidad de Navarra - Sede Madrid
RECRUITING

Madrid, 28027, Spain
Cliniques Universitaires St Luc Ucl
RECRUITING

Brussels, B-1200, Belgium
Concord General Repatriation Hospital
NOT_YET_RECRUITING

Concord, New South Wales, 02139, Australia
Florida Cancer Specialists & Research Institute
RECRUITING

Fort Myers, Florida, 33901, United States
Florida Cancer Specialists & Research Institute
RECRUITING

West Palm Beach, Florida, 33401, United States
Froedtert & the Medical College of Wisconsin
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Fundacion Instituto Valenciano de Oncologia
RECRUITING

Valencia, 46009, Spain
Geneva University Hospitals-Hug
NOT_YET_RECRUITING

Geneva, 01211, Switzerland
Greater Baltimore Medical Center
RECRUITING

Baltimore, Maryland, 21204, United States
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
RECRUITING

London, SE1 9RT, United Kingdom
Hammersmith Hospital - Imperial College Healthcare Nhs Trust
RECRUITING

London, W12 0HS, United Kingdom
Hobart Hospital-Royal Hobart Hospital
RECRUITING

Hobart, Tasmania, 07000, Australia
Hokkaido University Hospital
RECRUITING

Sapporo, 060-8648, Japan
Hopital Universitaire de Bruxelles (Hub) - Institut Jules Bordet
RECRUITING

Brussels, 01070, Belgium
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Valencia (Instituto de Investigacion Sanitaria Incliva)
RECRUITING

Valencia, 46010, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Reina Sofia
NOT_YET_RECRUITING

Córdoba, 14004, Spain
Hospital Universitario Vall D'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Virgen de La Arrixaca
RECRUITING

Murcia, 30120, Spain
Houston Methodist Cancer Center
WITHDRAWN

Houston, Texas, 77030, United States
Hyogo Cancer Center
RECRUITING

Akashi-shi, 673-8558, Japan
Institut Catala D'Oncologia Girona
RECRUITING

Girona, 17007, Spain
Instituto Catalan de Oncologia - Hospital Duran I Reynals
NOT_YET_RECRUITING

Barcelona, 08908, Spain
Istituto Oncologico Della Svizzera Italiana (Iosi) Di Bellinzona
NOT_YET_RECRUITING

Bellinzona, 06500, Switzerland
John Theurer Cancer Center, Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Kantonsspital Graubunden
NOT_YET_RECRUITING

Chur, 07000, Switzerland
Kurume University Hospital
RECRUITING

Kurume, 830-0011, Japan
Laura and Isaac Perlmutter Cancer Center
RECRUITING

New York, New York, 10016, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
WITHDRAWN

Jacksonville, Florida, 32224, United States
Medical University of South Carolina
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medstar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Minnesota Oncology-Minneapolis
RECRUITING

Minneapolis, Minnesota, 55404, United States
Mount Sinai Comprehensive Cancer Center
RECRUITING

Miami Beach, Florida, 33140, United States
Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States
Northeast Georgia Medical Center Gainesville
RECRUITING

Gainesville, Georgia, 30501, United States
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Oncology Hematology Care, Inc
RECRUITING

Cincinnati, Ohio, 45242, United States
Panoncology Trials
RECRUITING

San Juan, PR, 00935, Puerto Rico
Parkview Research Center
RECRUITING

Fort Wayne, Indiana, 46845, United States
Penn State College of Medicine
NOT_YET_RECRUITING

Hershey, Pennsylvania, 17033, United States
Royal Marsden Hospital (Sutton) - Royal Marsden Nhs Foundation Trust
RECRUITING

London, SM2 5PT, United Kingdom
Saitama Medical University International Medical Center
RECRUITING

Hidaka-shi, 350-1298, Japan
Scripps Healthscripps Mercy Hospital Prebys Cancer Center
RECRUITING

San Diego, California, 92103, United States
Shikoku Cancer Center
RECRUITING

Matsuyama, 791-0280, Japan
Shizuoka Cancer Center
RECRUITING

Sunto-gun, 411-8777, Japan
Southern Oncology Clinical Research Unit
WITHDRAWN

South Australia, 05042, Australia
St Bartholomew'S Hospital
NOT_YET_RECRUITING

London, EC1A 7BE, United Kingdom
St. Vincent Regional Hospital - West End Clinic
RECRUITING

Billings, Montana, 59106, United States
State University of New York Upstate Medical Unive
NOT_YET_RECRUITING

Syracuse, New York, 13210, United States
Sylvester Comprehensive Cancer Center
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
Texas Oncology-Austin Center
RECRUITING

Austin, Texas, 78731, United States
Texas Oncology-San Antonio Medical Center Pharmacy
RECRUITING

San Antonio, Texas, 78229, United States
Texas Oncology-Tyler
RECRUITING

Tyler, Texas, 75702, United States
The Cancer Institute Hospital of Jfcr
RECRUITING

Kōtoku, 135-8550, Japan
The Christie Nhs Foundation Trust
RECRUITING

Manchester Greater, M204BX, United Kingdom
The Mark H Zangmeister Cancer Center Ohio
RECRUITING

Columbus, Ohio, 43219, United States
The Ohio State University Wexner Medical Center Division of Gynecologic Oncology
NOT_YET_RECRUITING

Hilliard, Ohio, 43026, United States
Trials365, Llc
RECRUITING

Shreveport, Louisiana, 71103, United States
Uams Winthrop P Rockefeller Cancer Institute
NOT_YET_RECRUITING

Little Rock, Arkansas, 72205, United States
Umass Memorial Medical Center, Inc.
NOT_YET_RECRUITING

Worcester, Massachusetts, 01605, United States
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 03000, Belgium
University of California, Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90024-6995, United States
University of Iowa Hospital and Clinics
NOT_YET_RECRUITING

Iowa City, Iowa, 52242-1009, United States
University of Michigan Cancer Center
WITHDRAWN

Ann Arbor, Michigan, 48109, United States
University of Michigan Health System
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center
NOT_YET_RECRUITING

Jackson, Mississippi, 39216, United States
University of Rochester, James P. Wilmot Cancer Center
WITHDRAWN

Rochester, New York, 14642, United States
Usa Health Mitchell Cancer Institute
NOT_YET_RECRUITING

Mobile, Alabama, 36604, United States
Utah Cancer Specialists
RECRUITING

Salt Lake City, Utah, 84106, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

OVARIAN CANCER