New Two-Drug combo trial offers hope for women with recurrent ovarian cancer

NCT ID NCT06072781

Summary

This study is testing whether a new combination of two oral drugs (avutometinib and defactinib) works better than current standard treatments for women whose low-grade serous ovarian cancer has returned after prior therapy. The trial will involve about 270 participants worldwide who will be randomly assigned to receive either the new drug combination or one of four standard treatments chosen by their doctor. Researchers will primarily measure how long patients live without their cancer getting worse, while also tracking side effects, overall survival, and quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AO Cannizzaro

    RECRUITING

    Catania, 95126, Italy

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Aalborg U.H

    RECRUITING

    Aalborg, 9000, Denmark

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AdventHealth

    RECRUITING

    Orlando, Florida, 32804, United States

    Contact Email: •••••@•••••

    Contact

  • Agaplesion Markus Krankenhaus

    RECRUITING

    Frankfurt am Main, Hesse, 60431, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Aichi Cancer Center Hospital

    RECRUITING

    Aichi, Nagoya, 464-8681, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Allegheny Health Network

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

    Contact Email: •••••@•••••

    Contact

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

    Contact Email: •••••@•••••

    Contact

  • Asplundh Cancer Pavilion | Jefferson Health

    RECRUITING

    Philadelphia, Pennsylvania, 19090, United States

    Contact Email: •••••@•••••

    Contact

  • Atrium Health

    RECRUITING

    Charlotte, North Carolina, 28203, United States

    Contact

    Contact Email: •••••@•••••

  • Auckland City Hospital

    RECRUITING

    Auckland, 1023, New Zealand

    Contact Email: •••••@•••••

    Contact

  • Białostockie Centrum Onkologii

    RECRUITING

    Bialystok, 15-027, Poland

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • British of Columbia

    RECRUITING

    Vancouver, V5Z 4E6, Canada

    Contact

    Contact Email: •••••@•••••

  • Cambridge University Hospital

    RECRUITING

    Cambridge, CB2 0QQ, United Kingdom

    Contact

    Contact Email: •••••@•••••

  • Cancer Research South Australia

    RECRUITING

    Adelaide, South Australia, 5000, Australia

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  • Centre Hospitalier de Besançon

    RECRUITING

    Besançon, 25000, France

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    Contact Email: •••••@•••••

  • Centre Hospitalier de l'Universite de Montreal (CHUM)

    RECRUITING

    Montreal, Quebec, H2X 0C1, Canada

    Contact

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  • Centre Léon Bérard

    RECRUITING

    Lyon, 69373, France

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    Contact

  • Centre Oscar Lambret

    RECRUITING

    Lille, 59020, France

    Contact Email: •••••@•••••

    Contact

  • Centro di Riferimento Oncologico (CRO)

    RECRUITING

    Aviano, 33081, Italy

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Charité - Universitätsmedizin Berlin

    RECRUITING

    Berlin, 13353, Germany

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

    Contact

  • Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Email: •••••@•••••

    Contact

  • Clínico Virgen de La Arrixaca

    RECRUITING

    El Palmar, Murcia, 30120, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • European Institute of Oncology (IEO)

    RECRUITING

    Milan, Italy

    Contact Email: •••••@•••••

    Contact

  • Florida Cancer Specialists - South

    RECRUITING

    Fort Myers, Florida, 33901, United States

    Contact Email: •••••@•••••

    Contact

  • Florida Cancer Specialists Research East

    RECRUITING

    West Palm Beach, Florida, 33401, United States

    Contact

    Contact Email: •••••@•••••

  • Gangnam Severance Hospital

    RECRUITING

    Seoul, 06273, South Korea

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Gdański Uniwersytet Medyczny

    RECRUITING

    Gdansk, 80-214, Poland

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Greater Glasgow and Clyde (GGC)

    RECRUITING

    Glasgow, Scotland, G120YN, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • H. Vall d´ Hebron

    RECRUITING

    Barcelona, Spain

    Contact

    Contact Email: •••••@•••••

  • H. de Donostia

    RECRUITING

    Donostia / San Sebastian, San Sebastian, 20014, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • H.U. Ramón y Cajal

    RECRUITING

    Madrid, Spain

    Contact

    Contact Email: •••••@•••••

  • HonorHealth

    RECRUITING

    Phoenix, Arizona, 85016, United States

    Contact

    Contact Email: •••••@•••••

  • Hope Cancer Trials Centre

    RECRUITING

    Leicester, LE2 7LX, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Clínico Universitario de Santiago

    RECRUITING

    Santiago de Compostela, 15706, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Clínico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

    Contact

    Contact Email: •••••@•••••

  • Hospital Universitario Reina Sofía

    RECRUITING

    Córdoba, Spain

    Contact Email: •••••@•••••

    Contact

  • Houston Methodist

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Humanitas San Pio X

    RECRUITING

    Milan, 20159, Italy

    Contact

    Contact Email: •••••@•••••

  • INT Napoli Hospital

    RECRUITING

    Napoli, Italy

    Contact Email: •••••@•••••

    Contact

  • IRCCS Gemelli

    RECRUITING

    Roma, 00168, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Icon Cancer Centre Wesley

    RECRUITING

    Auchenflower, Queensland, 4066, Australia

    Contact Email: •••••@•••••

    Contact

  • Institut Curie

    RECRUITING

    Paris, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Intermountain Medical Center

    RECRUITING

    Murray, Utah, 84107, United States

    Contact Email: •••••@•••••

    Contact

  • Istituti Fisioterapici Ospitalieri

    RECRUITING

    Rome, 00144, Italy

    Contact Email: •••••@•••••

    Contact

  • Istituto Nazionale dei Tumori

    RECRUITING

    Milan, 20133, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Istituto Oncologico Veneto (IOV)

    RECRUITING

    Padua, 35128, Italy

    Contact Email: •••••@•••••

    Contact

  • Karmanos Cancer Center

    RECRUITING

    Detroit, Michigan, 48201, United States

    Contact Email: •••••@•••••

    Contact

  • Kliniken Essen-Mitte

    RECRUITING

    Essen, 45136, Germany

    Contact Email: •••••@•••••

    Contact

  • Louisiana State University

    RECRUITING

    New Orleans, Louisiana, 70112, United States

    Contact Email: •••••@•••••

    Contact

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

    Contact Email: •••••@•••••

  • McGill University Health Centre

    RECRUITING

    Montreal, Quebec, H4A 3J1, Canada

    Contact

    Contact Email: •••••@•••••

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact Phone: •••-•••-••••

    Contact

  • Minnesota Oncology Hematology

    RECRUITING

    Minneapolis, Minnesota, 55404, United States

    Contact Email: •••••@•••••

    Contact

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

  • Mount Sinai

    RECRUITING

    Miami Beach, Florida, 33140, United States

    Contact Email: •••••@•••••

    Contact

  • Netherlands Cancer Insitute

    RECRUITING

    Amsterdam, 1066, Netherlands

    Contact

    Contact Email: •••••@•••••

  • NorthShore University HealthSystem

    RECRUITING

    Evanston, Illinois, 60201, United States

    Contact

    Contact Email: •••••@•••••

  • Northwest Cancer Specialists

    RECRUITING

    Portland, Oregon, 97227, United States

    Contact

    Contact Email: •••••@•••••

  • Ohio State

    RECRUITING

    Hilliard, Ohio, 43026, United States

    Contact

    Contact Email: •••••@•••••

  • Osaka Medical Center

    RECRUITING

    Osaka, Japan

    Contact Email: •••••@•••••

    Contact

  • Peter MacCallum Cancer Centre

    RECRUITING

    Melbourne, Victoria, 3000, Australia

    Contact Email: •••••@•••••

    Contact

  • Prince of Wales Hospital

    RECRUITING

    Randwick, New South Wales, 2031, Australia

    Contact Email: •••••@•••••

    Contact

  • Princess Margaret Cancer Center

    RECRUITING

    Toronto, Ontario, M5G 1X6, Canada

    Contact

    Contact Email: •••••@•••••

  • Radboud UMC

    RECRUITING

    Nijmegen, 6525 GA, Netherlands

    Contact Email: •••••@•••••

    Contact

  • Roswell Park Cancer Institute

    RECRUITING

    Buffalo, New York, 14263, United States

    Contact

    Contact Email: •••••@•••••

  • Royal Marsden Hospital

    RECRUITING

    London, SW7 3RP, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • Royal Marsden Hospital

    RECRUITING

    Sutton, SM2 5PT, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • S.C.D.U. Oncologia

    RECRUITING

    Torino, 10128, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • San Raffaele Hospital

    RECRUITING

    Milan, 20132, Italy

    Contact

    Contact Email: •••••@•••••

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam, 13620, South Korea

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

    Contact

  • Siedleckie Centrum Onkologii

    RECRUITING

    Siedlce, 98-110, Poland

    Contact

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

  • Sir Charles Gairdner Hospital

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

    Contact Email: •••••@•••••

    Contact

  • Site Georges François Leclerc

    RECRUITING

    Dijon, 21079, France

    Contact

    Contact Email: •••••@•••••

  • Spedali Civili

    RECRUITING

    Brescia, 25123, Italy

    Contact Email: •••••@•••••

    Contact

  • St. James's Hospital

    RECRUITING

    Dublin, 08, Ireland

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Oncology

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact

    Contact Email: •••••@•••••

  • Texas Oncology

    RECRUITING

    The Woodlands, Texas, 77380, United States

    Contact Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

  • Texas Oncology

    RECRUITING

    Tyler, Texas, 75702, United States

    Contact

    Contact Email: •••••@•••••

  • Texas Oncology Central

    RECRUITING

    Austin, Texas, 78731, United States

    Contact

    Contact Email: •••••@•••••

  • Texas Oncology-Fort Worth Cancer Center

    RECRUITING

    Fort Worth, Texas, 76104, United States

    Contact

    Contact Email: •••••@•••••

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, United Kingdom

    Contact

    Contact Email: •••••@•••••

  • The Jikei University Hospital

    RECRUITING

    Tokyo, 3-19-18, Japan

    Contact Email: •••••@•••••

    Contact

  • The Mie University Hospital

    RECRUITING

    Tsu, Mie-ken, 514-8507, Japan

    Contact Email: •••••@•••••

    Contact

  • Tohoku University Hospital

    RECRUITING

    Miyagi, 980-8574, Japan

    Contact Email: •••••@•••••

    Contact

  • UC Davis

    RECRUITING

    Sacramento, California, 95817, United States

    Contact

    Contact Email: •••••@•••••

  • UCLA Health

    RECRUITING

    Los Angeles, California, 90095, United States

    Contact Email: •••••@•••••

    Contact

  • UMC Hamburg-Eppendorf

    RECRUITING

    Hamburg, 20246, Germany

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UZA

    RECRUITING

    Edegem, 2650, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University College London Hospitals NHS Foundation Trust

    RECRUITING

    London, NW1 2PG, United Kingdom

    Contact Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

  • University Hospital Ghent

    RECRUITING

    Ghent, 9000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Arkansas

    RECRUITING

    Little Rock, Arkansas, 72205, United States

    Contact

    Contact Email: •••••@•••••

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

    Contact

    Contact Email: •••••@•••••

  • University of Edinburgh Cancer Research Centre

    RECRUITING

    Edinburgh, United Kingdom

    Contact

    Contact Email: •••••@•••••

  • University of Oklahoma Medical Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

    Contact

    Contact Email: •••••@•••••

  • University of Virginia Health System

    RECRUITING

    Charlottesville, Virginia, 22908, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Universitätsfrauenkinik Ulm

    RECRUITING

    Ulm, 89075, Germany

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Universitätsklinikum Carl Gustav Carus

    RECRUITING

    Dresden, 01307, Germany

    Contact

    Contact Email: •••••@•••••

  • Universitätsklinikum Mannheim GmbH

    RECRUITING

    Mannheim, 68167, Germany

    Contact

    Contact Email: •••••@•••••

  • Virginia Cancer Specialists, PC

    RECRUITING

    Gainesville, Virginia, 20155, United States

    Contact Email: •••••@•••••

    Contact

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Email: •••••@•••••

    Contact

  • Willamette Valley Cancer Institute

    RECRUITING

    Eugene, Oregon, 97401, United States

    Contact

    Contact Email: •••••@•••••

  • Winship Cancer Institute at Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact

    Contact Email: •••••@•••••

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact

    Contact Email: •••••@•••••

  • Yonsei University Severance Hospital

    RECRUITING

    Seoul, 03722, South Korea

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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