New hope for Hard-to-Treat ovarian cancer: targeted drug vs chemotherapy

NCT ID NCT07214779

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 34 times

Summary

This study tests a new drug, INCB123667, against standard chemotherapy in people with a type of ovarian cancer that no longer responds to platinum-based treatments. The trial includes about 466 adults whose tumors have a specific marker called cyclin E1 overexpression. The goal is to see if the new drug can slow cancer growth or improve survival better than chemotherapy.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Aichi Cancer Center
NOT_YET_RECRUITING

Nagoya, 464-8681, Japan
Alaska Womens Cancer Care Akwcc
NOT_YET_RECRUITING

Anchorage, Alaska, 99508, United States
Asan Medical Center
NOT_YET_RECRUITING

Seoul, 05505, South Korea
Atrium Health Wake Forest Baptist
NOT_YET_RECRUITING

Winston-Salem, North Carolina, 27157, United States
Ausl Di Placenza Ospedale Guglielmo Da Saliceto
NOT_YET_RECRUITING

Placenza, 29121, Italy
Az Groeninge
NOT_YET_RECRUITING

Kortrijk, 08500, Belgium
Az Maria Middelares Gent
NOT_YET_RECRUITING

Ghent, 09000, Belgium
Azienda Ospedaliero-Universitaria Di Alessandria Ss.Antonio E Biagio E Cesare Arrigo
WITHDRAWN

Alessandria, 15121, Italy
Azienda Ospedaliero-Universitaria Orsola-Malpighi - Universita Degli Studi Di Bologna
NOT_YET_RECRUITING

Bologna, 40138, Italy
Azienda Sanitaria Universitaria Friuli Centrale Asu Fc
NOT_YET_RECRUITING

Udine, 33100, Italy
Azienda Socio Santaria Territoriale de Lecco - Ospedale A. Manzoni
NOT_YET_RECRUITING

Lecco, 23900, Italy
Azienda Ulss 3 Serenissima - Ospedale Di Mirano
NOT_YET_RECRUITING

Mirano, 30035, Italy
Bc Cancer Vancouver
WITHDRAWN

Vancouver, British Columbia, V5Z 1L3, Canada
Billings Clinic
RECRUITING

Billings, Montana, 59101, United States
British Columbia Cancer Agency (Bcca) - Abbotsford Regional Hospital and Cancer Centre (Arhcc)
WITHDRAWN

Abbotsford British Columbia, British Columbia, V2S 0C2, Canada
Carle Cancer Center
NOT_YET_RECRUITING

Effingham, Illinois, 62401-2006, United States
Cedars Cancer Centre - McGill University Health Centre (Muhc) - Glen Site
NOT_YET_RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Center of Hope
NOT_YET_RECRUITING

Reno, Nevada, 89502, United States
Centre Antoine Laccassagne
NOT_YET_RECRUITING

Nice, 06189, France
Centre Eugene Marquis
NOT_YET_RECRUITING

Rennes, 35042, France
Centre Hospitalier Departemental de Vendee, Hopital de La-Roche-Sur-Yon Les Oudairies
NOT_YET_RECRUITING

La Roche-sur-Yon, 85925, France
Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) - Centre Du Cancer Lausanne-Batiment Hospit
NOT_YET_RECRUITING

Lausanne, 01011, Switzerland
Centre Hospitalier Universitaire de Grenoble- Hopital Albert Michallon
NOT_YET_RECRUITING

La Tronche, 38700, France
Centro Di Riferimento Oncologico Di Aviano
NOT_YET_RECRUITING

Aviano, 33081, Italy
Ch Davignon - Hopital Henri Duffaut
NOT_YET_RECRUITING

Avignon, 84902, France
Cha University Bundang Cha Medical Center
NOT_YET_RECRUITING

Seongnam-si, 13520, South Korea
Chris O'Brien Lifehouse Hospital
NOT_YET_RECRUITING

Camperdown, New South Wales, 02050, Australia
City of Hope Medical Center
NOT_YET_RECRUITING

Duarte, California, 91010, United States
Clatterbridge Cancer Center
NOT_YET_RECRUITING

Liverpool, L7 8YA, United Kingdom
Clinica Universidad de Navarra
NOT_YET_RECRUITING

Madrid, 28022, Spain
Clinique Pole Sante Leonard de Vinci
NOT_YET_RECRUITING

Chambray-lès-Tours, 37170, France
Clinique Tivoli
NOT_YET_RECRUITING

Bordeaux, 33000, France
Cliniques Universitaires St Luc Ucl
NOT_YET_RECRUITING

Brussels, B-1200, Belgium
Comitato Etico Irccs Istituto Oncologico Veneto Di Padova
NOT_YET_RECRUITING

Padova, 35128, Italy
Corporacio Sanitaria Universitaria Parc Tauli
NOT_YET_RECRUITING

Sabadell, 08208, Spain
Cross Cancer Institute
NOT_YET_RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Eastern Health-Box Hill Hospital
NOT_YET_RECRUITING

Box Hill, Victoria, 03128, Australia
Edinburgh Cancer Centre Western General Hospital
WITHDRAWN

Edinburgh, EH4 2XU, United Kingdom
Erasmus Medisch Centrum 1
NOT_YET_RECRUITING

Rotterdam, 3015 GD, Netherlands
Erlanger Health, Inc.
RECRUITING

Chattanooga, Tennessee, 37403, United States
Ewha Womans University Mokdong Hospital
NOT_YET_RECRUITING

Seoul, 07985, South Korea
Fondazione Irccs Istituto Nazionale Dei Tumori
NOT_YET_RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli Irccs - Universita Cattolica Del Sacro Cuore
NOT_YET_RECRUITING

Rome, 00168, Italy
Fred Hutchinson Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States
Gdanski Uniwersytet Medyczny
NOT_YET_RECRUITING

Gdansk, 80-214, Poland
Georgia Cancer Center
NOT_YET_RECRUITING

Augusta, Georgia, 30912, United States
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
NOT_YET_RECRUITING

London, SE1 9RT, United Kingdom
Hammersmith Hospital - Imperial College Healthcare Nhs Trust
NOT_YET_RECRUITING

London, W12 0HS, United Kingdom
Hokkaido University Hospital
NOT_YET_RECRUITING

Sapporo, 060-8648, Japan
Holy Cross Hospital
NOT_YET_RECRUITING

Silver Spring, Maryland, 20910, United States
Hopital Prive Jean Mermoz
NOT_YET_RECRUITING

Lyon, 69008, France
Hopital Universitaire de Bruxelles (Hub) - Institut Jules Bordet
NOT_YET_RECRUITING

Brussels, 01070, Belgium
Hopital de Hautepierre
NOT_YET_RECRUITING

Strasbourg, 67098, France
Hopitaux Universitaires de Geneve (Hug) (Hopital Cantonal)
NOT_YET_RECRUITING

Geneva, 01205, Switzerland
Hospital Clinic de Barcelona
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Valencia (Instituto de Investigacion Sanitaria Incliva)
NOT_YET_RECRUITING

Valencia, 46010, Spain
Hospital Son Espases. Mallorca
NOT_YET_RECRUITING

Palma de Mallorca, 07120, Spain
Hospital Universitario Central de Asturias
NOT_YET_RECRUITING

Oviedo, 33011, Spain
Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen Del Rocío Sevilla
NOT_YET_RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen de La Victoria
NOT_YET_RECRUITING

Málaga, 29010, Spain
Hospital Universitario Virgen de Valme
NOT_YET_RECRUITING

Seville, 41014, Spain
Hospital Universitario de Alava
NOT_YET_RECRUITING

Alava, 01009, Spain
Humanitas San Pio X
NOT_YET_RECRUITING

Milan, 20159, Italy
Hyogo Cancer Center
NOT_YET_RECRUITING

Akashi-shi, 673-8558, Japan
Ico-Badalona
NOT_YET_RECRUITING

Badalona, 89016, Spain
Icon Cancer Care - Townsville
NOT_YET_RECRUITING

Townsville, Queensland, 04812, Australia
Inova Schar Cancer Institute
NOT_YET_RECRUITING

Fairfax, Virginia, 22031, United States
Institut Gustave Roussy-Gustave Roussy Cancer Center -Ditep
NOT_YET_RECRUITING

Villejuif, 94805, France
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, 13009, France
Istituti Fisioterapici Ospitalieri-Istituto Nazionale Tumori Regina Elena (Ire)
NOT_YET_RECRUITING

Rome, 00144, Italy
Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) - Ospedale San Raffaele (Hsr) (Istituto
NOT_YET_RECRUITING

Milan, 20132, Italy
Istituto Nazionale Tumori Irccs Fondazione Pascale
NOT_YET_RECRUITING

Naples, 80131, Italy
Iwate Medical University Hospital
NOT_YET_RECRUITING

Shiwa-gun, 028-3695, Japan
Johannes Wesling Klinikum Minden
NOT_YET_RECRUITING

Minden, 32429, Germany
Kantonsspital Frauenfeld
NOT_YET_RECRUITING

Frauenfeld, 08501, Switzerland
Kantonsspital Graubunden
NOT_YET_RECRUITING

Chur, 07000, Switzerland
Klinikum Kassel
NOT_YET_RECRUITING

Kassel, 34125, Germany
Konkuk University Medical Center
NOT_YET_RECRUITING

Seoul, 05030, South Korea
Korea University Anam Hospital
NOT_YET_RECRUITING

Seoul, 02841, South Korea
Kurume University Hospital
NOT_YET_RECRUITING

Kurume, 830-0011, Japan
Levine Cancer Center
NOT_YET_RECRUITING

Charlotte, North Carolina, 28204, United States
Lmu - Klinikum Der Universitaet Muenchen - Campus Grosshadern
NOT_YET_RECRUITING

München, 81377, Germany
London Health Sciences Centre
NOT_YET_RECRUITING

London, Ontario, N6A 5W9, Canada
Maine Center For Cancer Medicine
NOT_YET_RECRUITING

Scarborough, Maine, 04074, United States
Mater Misericordiae University Hospital
NOT_YET_RECRUITING

Dublin, D07 R2WY, Ireland
Mazowiecki Szpital Wojewodzki, Siedleckie Centrum Onkologii
NOT_YET_RECRUITING

Siedlce, 08-110, Poland
Mercy Hospital St. Louis - David C. Pratt Cancer Center
NOT_YET_RECRUITING

St Louis, Missouri, 63141, United States
Mount Vernon Cancer Centre
NOT_YET_RECRUITING

Northwood, HA6 2RN, United Kingdom
Musgrove Park Hospital - Somerset Nhs Foundation Trust
NOT_YET_RECRUITING

Taunton, TA1 5DA, United Kingdom
National Cancer Center
NOT_YET_RECRUITING

Goyang-si, 10408, South Korea
National Cancer Center Hospital
NOT_YET_RECRUITING

Tokyo, 104-0045, Japan
Nho Shikoku Cancer Center
NOT_YET_RECRUITING

Matsuyama, 791-0280, Japan
Nki-Avl (Nederlands Kanker Instituut-Anthonie Van Leeuwenhoek)
NOT_YET_RECRUITING

Amsterdam, 1066 CX, Netherlands
North Coast Cancer Institute
WITHDRAWN

Port Macquarie, New South Wales, 02444, Australia
Northampton General Hospital - Northampton General Hospital Nhs Trust
NOT_YET_RECRUITING

Northampton, NN1 5BD, United Kingdom
Northshore University Health System-Evanston Hospital
NOT_YET_RECRUITING

Evanston, Illinois, 60201, United States
Novant Health Oncology Specialists
NOT_YET_RECRUITING

Winston-Salem, North Carolina, 27103, United States
Novant Presbyterian Hospital
NOT_YET_RECRUITING

Charlotte, North Carolina, 28204, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Oncology Associates of Oregon, P.C.
NOT_YET_RECRUITING

Eugene, Oregon, 97401, United States
Ordine Mauriziano - Ospedale Umberto I Di Torino
NOT_YET_RECRUITING

Torino, 10128, Italy
Osaka International Cancer Institute
RECRUITING

Osaka, 541-8567, Japan
Ospedale Ca' Foncello
NOT_YET_RECRUITING

Treviso, 31100, Italy
Ospedale Careggi
NOT_YET_RECRUITING

Florence, 50134, Italy
Ospedale Ferrero
NOT_YET_RECRUITING

Verduno, 12060, Italy
Ospedale Regionale Di Bellinzona
NOT_YET_RECRUITING

Bellinzona, 06500, Switzerland
Ospedale Santa Maria Delle Croci
NOT_YET_RECRUITING

Ravenna, 48121, Italy
Providence Cancer Institute Franz Clinic
NOT_YET_RECRUITING

Portland, Oregon, 97213, United States
Radboud University Medical Center
NOT_YET_RECRUITING

Nijmegen, 6525 GA, Netherlands
Royal Marsden Hospital
NOT_YET_RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Surrey County Hospital - Royal Surrey County Hospital Nhs Foundation Trust
NOT_YET_RECRUITING

Guildford, GU2 7XX, United Kingdom
Saitama Medical University International Medical Center
NOT_YET_RECRUITING

Hidaka-shi, 350-1298, Japan
Samsung Changwon Hospital
NOT_YET_RECRUITING

Changwon-si, 51353, South Korea
Samsung Medical Center
NOT_YET_RECRUITING

Seoul, 06351, South Korea
Sanford Cancer Center-Sioux Falls
NOT_YET_RECRUITING

Sioux Falls, South Dakota, 57104-8805, United States
Sapporo Medical University Hospital
RECRUITING

Sapporo, 060-8543, Japan
Seoul National University Bundang Hospital (Snubh)
NOT_YET_RECRUITING

Seongnam-si, 13620, South Korea
Seoul National University Hospital
NOT_YET_RECRUITING

Seoul, 03080, South Korea
Seoul St. Mary'S Hospital
NOT_YET_RECRUITING

Seoul, 06591, South Korea
Shizuoka Cancer Center
NOT_YET_RECRUITING

Sunto-gun, 411-8777, Japan
Sir Mortimer B. Davis - Jewish General Hospital
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Ss Antonio & Biagio and C. Arrigo Hospital
NOT_YET_RECRUITING

Alessandria, 15121, Italy
St James'S University Hospital - Leeds Teaching Hospitals Nhs Trust
NOT_YET_RECRUITING

Leeds, LS9 7TF, United Kingdom
St. James Hospital
NOT_YET_RECRUITING

Dublin, D08 NHY1, Ireland
St. Vincent'S University Hospital
NOT_YET_RECRUITING

Dublin, D04 Y8V0, Ireland
Sunnybrook Health Science Centre
WITHDRAWN

Toronto, Ontario, M4N 3M5, Canada
Swietokrzyskie Centrum Onkologii Spzoz
NOT_YET_RECRUITING

Kielce, 25-734, Poland
Tenon - Aphp
NOT_YET_RECRUITING

Paris, 75020, France
Texas Oncology-Abilene
NOT_YET_RECRUITING

Abilene, Texas, 79606, United States
The Cancer Institute Hospital of Jfcr
NOT_YET_RECRUITING

Kōtoku, 135-8550, Japan
The Christie Nhs Foundation Trust
NOT_YET_RECRUITING

Manchester Greater, M204BX, United Kingdom
The Jikei University Hospital
RECRUITING

Minatoku, 105-8471, Japan
The Wollongong Hospital
NOT_YET_RECRUITING

Wollongong, New South Wales, 02500, Australia
Tohoku University Hospital
RECRUITING

Sendai, 980-8574, Japan
Tom Baker Cancer Center-Alberta Health Services (Ahs) - University of Calgary
NOT_YET_RECRUITING

Calgary, Alberta, T2N 4N2, Canada
Trillium Health Partners - Credit Valley Hospital
NOT_YET_RECRUITING

Mississauga, L5M 2N1, Canada
UZ GENT
NOT_YET_RECRUITING

Ghent, 09000, Belgium
Universita Degli Studi Di Pavia-Fondazione Irccs Policlinico San Matteo
NOT_YET_RECRUITING

Pavia, 27100, Italy
Universitaetsklinikum Tuebingen (Ukt)
NOT_YET_RECRUITING

Tübingen, 72076, Germany
Universitair Medisch Centrum Utrecht (Umc Utrecht)
NOT_YET_RECRUITING

Utrecht, 3584 CX, Netherlands
Universitair Ziekenhuis Leuven
NOT_YET_RECRUITING

Leuven, 03000, Belgium
Universitatsklinikum Schleswig Holstein
NOT_YET_RECRUITING

Kiel, 24105, Germany
University Clinic Carl Gustav Carus Technical University Dresden
NOT_YET_RECRUITING

Dresden, 01307, Germany
University College London Hospitals - University College London Hospitals Nhs Foundation Trust
NOT_YET_RECRUITING

London, NW1 2BU, United Kingdom
University Health Network (Uhn) - Princess Margaret Cancer Centre
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University Hospital Waterford
NOT_YET_RECRUITING

Waterford, X91 ER8E, Ireland
University Hospital of Zurich
NOT_YET_RECRUITING

Zurich, 08032, Switzerland
University Medical Center Groningen
NOT_YET_RECRUITING

Groningen, 9713 GZ, Netherlands
University of Colorado Cancer Center
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States
University of Pittsburgh Cancer Institute Cancer Services
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Universitätsklinikum Bonn
NOT_YET_RECRUITING

Bonn, 53127, Germany
Universitätsklinikum Ulm
NOT_YET_RECRUITING

Ulm, 89075, Germany
Universitätsmedizin Mannheim
NOT_YET_RECRUITING

Mannheim, 68167, Germany
Uniwersytecki Szpital Kliniczny Nr 2 Pomorskiego Uniwersytetu Medycznego W Szczecinie
NOT_YET_RECRUITING

Szczecin, 70-111, Poland
Uniwersyteckie Centrum Onkologii
NOT_YET_RECRUITING

Bialystok, 15-276, Poland
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Velindre Nhs Trust, Velindre Cancer Centre
NOT_YET_RECRUITING

Cardiff, CF14 2TL, United Kingdom
Vidia Christliche Kliniken Karlsruhe
WITHDRAWN

Karlsruhe, 76135, Germany
Wellspan Gynecologic Oncology
NOT_YET_RECRUITING

York, Pennsylvania, 17403, United States
Women'S Cancer Care
NOT_YET_RECRUITING

Covington, Louisiana, 70433, United States

Conditions

Explore the condition pages connected to this study.

OVARIAN CANCER