New drug combo aims to keep ovarian cancer at bay longer

NCT ID NCT06824467

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 30 times

Summary

This study tests whether a new drug combination (sacituzumab tirumotecan with or without bevacizumab) can help people with platinum-sensitive recurrent ovarian cancer live longer without their cancer worsening. About 770 adults who have already had two rounds of chemotherapy will be randomly assigned to receive the new treatment or standard care. The goal is to see if the new approach is safer and more effective at delaying cancer progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

ANIMI - Unidade de Tratamento Oncologico ( Site 0419)
RECRUITING

Lages, Santa Catarina, 88501-001, Brazil

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ATTIKON GENERAL UNIVERSITY HOSPITAL-Oncology ( Site 0702)
RECRUITING

Chaïdári, Attica, 12462, Greece

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AZ Sint-Lucas ( Site 0305)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium

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Aalborg Universitetshospital ( Site 0901)
RECRUITING

Aalborg, North Denmark, 9000, Denmark

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Aichi Cancer Center ( Site 1626)
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan

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Alaska Women's Cancer Care ( Site 0096)
RECRUITING

Anchorage, Alaska, 99508, United States

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Antwerp University Hospital ( Site 0304)
RECRUITING

Edegem, Antwerpen, 2650, Belgium

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Aretaieio Hospital ( Site 0701)
RECRUITING

Athens, Attica, 115 28, Greece

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Asan Medical Center ( Site 2304)
RECRUITING

Songpa-gu, Seoul, 05505, South Korea

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Augusta University - Georgia Cancer Center ( Site 0066)
RECRUITING

Augusta, Georgia, 30912, United States

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Azienda Ospedaliero Universitaria Pisana ( Site 1504)
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Pisa, Tuscany, 56126, Italy

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Bacs-Kiskun Megyei Korhaz ( Site 3920)
RECRUITING

Kecskemét, Bács-Kiskun county, 6000, Hungary

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Bialostockie Centrum Onkologii ( Site 2104)
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-027, Poland

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Blacktown Hospital ( Site 0211)
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Sydney, New South Wales, 2148, Australia

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CHU UCL Namur/Site Sainte Elisabeth ( Site 0302)
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Ghent, Oost-Vlaanderen, 9000, Belgium

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CIO - Centro de Inmuno-Oncología de Occidente ( Site 1719)
RECRUITING

Guadalajara, Jalisco, 44630, Mexico

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COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 1717)
RECRUITING

Mexico City, 04700, Mexico

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CRO-IRCCS ( Site 1510)
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy

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Cabinet Medical Oncomed ( Site 2217)
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Timișoara, Timiș County, 300239, Romania

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Cambridge University Hospital ( Site 2803)
RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom

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Cancer Institute Hospital of JFCR ( Site 1639)
RECRUITING

Koto, Tokyo, 135-8550, Japan

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Centre Francois Baclesse ( Site 1108)
RECRUITING

Caen, Calvados, 14076, France

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Centre Hopitalier Lyon Sud ( Site 1110)
RECRUITING

Pierre-Bénite, Auvergne-Rhône-Alpes, 69310, France

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Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0306)
RECRUITING

Liège, Liege, 4000, Belgium

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Centre Oscar Lambret ( Site 1104)
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Lille, Ain, 59020, France

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Centro de Investigacion Clinica de Oaxaca ( Site 1714)
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Oaxaca City, 68020, Mexico

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Centro de Investigación Oncológica Galerías SC ( Site 1720)
RECRUITING

Aguascalientes, 20124, Mexico

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Chang Gung Memorial Hospital - Linkou Branch ( Site 2605)
RECRUITING

Taoyuan, 333, Taiwan

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Clinica Puerto Montt ( Site 0615)
RECRUITING

Port Montt, Los Lagos Region, 5507642, Chile

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Clinica Universidad de Navarra ( Site 2407)
RECRUITING

Madrid, Madrid, Comunidad de, 28027, Spain

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Clínica San Felipe ( Site 3603)
RECRUITING

Lima, 15072, Peru

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Cryptex Investigación Clínica S.A. de C.V. ( Site 1715)
RECRUITING

Cuauhtémoc, 6100, Mexico

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Debreceni Egyetem Klinikai Kozpont ( Site 3922)
RECRUITING

Debrecen, Hajdú-Bihar, 4032, Hungary

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Ehime University Hospital ( Site 1637)
RECRUITING

Tōon, Ehime, 791-0295, Japan

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Epworth Freemasons ( Site 0217)
RECRUITING

East Melbourne, Victoria, 3002, Australia

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FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0806)
RECRUITING

Bogotá, Bogota D.C., 110131, Colombia

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Faculty of Medicine Siriraj Hospital ( Site 3401)
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Bangkok, Bangkok, 10700, Thailand

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Fakultni nemocnice Ostrava ( Site 3323)
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Ostrava-Poruba, Ostrava Mesto, 708 52, Czechia

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Fakultni nemocnice v Motole ( Site 3322)
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Prague, 150 06, Czechia

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FirstHealth Cancer Center ( Site 0079)
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Pinehurst, North Carolina, 28374, United States

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Florida Cancer Specialists East ( Site 7000)
RECRUITING

West Palm Beach, Florida, 33401, United States

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Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1507)
RECRUITING

Milan, Milano, 20133, Italy

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Fondazione Policlinico Universitario Agostino Gemelli ( Site 1502)
RECRUITING

Roma, 00168, Italy

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Frankston Hospital ( Site 0216)
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Frankston, Victoria, 3199, Australia

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Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0413)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil

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Fundación Respirar ( Site 2912)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1426AAL, Argentina

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Gallipoli Medical Research Ltd ( Site 0214)
RECRUITING

Brisbane, Queensland, 4120, Australia

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Groupe Hospitalier Broca Cochin Hotel Dieu ( Site 1111)
RECRUITING

Paris, Paris, 75014, France

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Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1102)
RECRUITING

Paris, 75020, France

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Gunma Prefectural Cancer Center ( Site 1630)
RECRUITING

Ōta, Gunma, 373-8550, Japan

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Henry-Joyce Cancer Clinic ( Site 0060)
RECRUITING

Nashville, Tennessee, 37232, United States

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Herlev Hospital ( Site 0903)
RECRUITING

Herlev, Capital Region, 2730, Denmark

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Higiea Oncologia ( Site 1713)
RECRUITING

Mexico City, Mexico City, 11819, Mexico

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Hillel Yaffe Medical Center ( Site 1404)
RECRUITING

Hadera, 3810101, Israel

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Hokkaido University Hospital ( Site 1634)
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan

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Hosp Clinico Universitario de Valencia ( Site 2401)
RECRUITING

Valencia, Valenciana, Comunitat, 46010, Spain

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Hospital Aleman ( Site 2903)
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CABA, C1118AAT, Argentina

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Hospital Clinic I Provincial de Barcelona ( Site 2409)
RECRUITING

Barcelona, 08036, Spain

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Hospital Clinico San Carlos... ( Site 2410)
RECRUITING

Madrid, 28040, Spain

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Hospital General Gregorio Maranon de Madrid ( Site 2412)
RECRUITING

Madrid, Madrid, Comunidad de, 28007, Spain

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Hospital Guillermo Almenara Irigoyen ( Site 3608)
RECRUITING

Lima, 15001, Peru

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Hospital Italiano de Cordoba ( Site 2908)
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Córdoba, 5000, Argentina

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Hospital Paulistano ( Site 0421)
RECRUITING

São Paulo, 01321-001, Brazil

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Hospital Ramon y Cajal ( Site 2405)
RECRUITING

Madrid, 28034, Spain

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Hospital São Lucas da PUCRS ( Site 0425)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610000, Brazil

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Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 1711)
RECRUITING

Monterrey, Nuevo León, 64460, Mexico

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Hospital Universitario 12 de Octubre ( Site 2411)
RECRUITING

Madrid, 28041, Spain

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Hospital Universitario La Paz ( Site 2404)
RECRUITING

Madrid, 28046, Spain

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Hospital Universitario Reina Sofia ( Site 2406)
RECRUITING

Córdoba, 14004, Spain

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Hospital Vall D Hebron ( Site 2403)
RECRUITING

Barcelona, 08035, Spain

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Hospital da Luz ( Site 3802)
RECRUITING

Lisbon, 1500-650, Portugal

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Humanitas San Pio X Hospital ( Site 1503)
RECRUITING

Milan, 20159, Italy

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Hôpital Privé Des Côtes d'Armor ( Site 1106)
RECRUITING

Plérin, Cotes-d Armor, 22190, France

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I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 1716)
RECRUITING

Monterrey, Nuevo León, 64710, Mexico

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IBCC - Núcleo de Pesquisa e Ensino ( Site 0424)
RECRUITING

São Paulo, 04014-002, Brazil

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ICO L Hospitalet ( Site 2408)
RECRUITING

Barcelona, 08907, Spain

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INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 3601)
RECRUITING

Lima, 15038, Peru

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IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3604)
RECRUITING

Lima, 15036, Peru

Contact Phone: •••-•••-••••
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 3801)
RECRUITING

Porto, 4200-072, Portugal

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Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1101)
RECRUITING

Bordeaux, Aquitaine, 33076, France

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Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
RECRUITING

Girona, Gerona, 17007, Spain

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Institut De Cancerologie De L Ouest ( Site 1107)
RECRUITING

Saint-Herblain, Pays de la Loire Region, 44805, France

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Instituto Alexander Fleming ( Site 2909)
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

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Instituto Nacional De Cancerologia ( Site 0807)
RECRUITING

Bogotá, Bogota D.C., 111511, Colombia

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Instituto Tumori Giovanni Paolo II ( Site 1505)
RECRUITING

Bari, 70124, Italy

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Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina

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Instituto de Oncologia de Rosario ( Site 2910)
RECRUITING

Rosario, Santa Fe Province, S2000KZE, Argentina

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Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2215)
RECRUITING

Cluj-Napoca, Cluj, 400015, Romania

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Istituto Europeo di Oncologia ( Site 1506)
RECRUITING

Milan, 20141, Italy

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Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1501)
RECRUITING

Naples, 80131, Italy

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Istituto Oncologico Veneto IRCCS ( Site 1508)
RECRUITING

Padova, 35128, Italy

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Istituto Ospedaliero,Fondazione Poliambulanza ( Site 1511)
RECRUITING

Brescia, 25124, Italy

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Iwate Medical University Hospital ( Site 1635)
RECRUITING

Shiwa-gun, Iwate, 028-3695, Japan

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John Theurer Cancer Center at Hackensack University Medical Center ( Site 0081)
RECRUITING

Hackensack, New Jersey, 07601, United States

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Kagoshima City Hospital ( Site 1638)
RECRUITING

Kagoshima, 890-8760, Japan

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Keio University Hospital ( Site 1636)
RECRUITING

Shinjyuku, Tokyo, 160-8582, Japan

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Kuopion Yliopistollinen Sairaala ( Site 1004)
RECRUITING

Kuopio, Northern Savonia, 70200, Finland

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Kurume University Hospital ( Site 1640)
RECRUITING

Kurume, Fukuoka, 830-0011, Japan

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Laura and Isaac Perlmutter Cancer Center ( Site 0076)
RECRUITING

New York, New York, 10016, United States

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Leicester Royal Infirmary ( Site 2808)
RECRUITING

Leicester, LE1 5WW, United Kingdom

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Liga Norte Riograndense Contra o Cancer ( Site 0423)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil

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Mackay Memorial Hospital ( Site 2604)
RECRUITING

Taipei, 104, Taiwan

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Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0008)
RECRUITING

Scarborough, Maine, 04074, United States

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McGill University Health Centre ( Site 0502)
RECRUITING

Montreal, Quebec, H4A 3J1, Canada

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Meir Medical Center. ( Site 1403)
RECRUITING

Kfar Saba, 4428164, Israel

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Mount Sinai Cancer Center ( Site 0078)
RECRUITING

Miami Beach, Florida, 33140, United States

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NYU Langone Hospital - Long Island ( Site 0015)
RECRUITING

Mineola, New York, 11501, United States

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National Cancer Center ( Site 2305)
RECRUITING

Goyang-si, Kyonggi-do, 10408, South Korea

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National Cheng Kung University Hospital ( Site 2602)
RECRUITING

Tainan, 704302, Taiwan

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National Hospital Organization Kyushu Cancer Center ( Site 1628)
RECRUITING

Fukuoka, 811-1395, Japan

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National Hospital Organization Shikoku Cancer Center ( Site 1631)
RECRUITING

Matsuyama, Ehime, 791-0280, Japan

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National Taiwan University Hospital ( Site 2601)
RECRUITING

Taipei, 10002, Taiwan

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Nebraska Methodist Hospital ( Site 0053)
RECRUITING

Omaha, Nebraska, 68114, United States

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Niigata Cancer Center Hospital ( Site 1633)
RECRUITING

Niigata, 951-8566, Japan

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ONCOCENTRO APYS-ACEREY ( Site 0612)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile

Contact Phone: •••-•••-••••
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0056)
RECRUITING

Tulsa, Oklahoma, 74146, United States

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Oncologos Del Occidente ( Site 0805)
RECRUITING

Pereira, Risaralda Department, 660001, Colombia

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Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8010)
RECRUITING

Eugene, Oregon, 97401, United States

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Oncopole Claudius Regaud ( Site 1109)
RECRUITING

Toulouse, Haute-Garonne, 31059, France

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Országos Onkológiai Intézet-Ngyógyászat ( Site 3923)
RECRUITING

Budapest, Pest County, 1122, Hungary

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Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1629)
RECRUITING

Osaka, 541-8567, Japan

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Ospedale Mauriziano ( Site 1509)
RECRUITING

Torino, 10128, Italy

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Oulun yliopistollinen sairaala ( Site 1003)
RECRUITING

Oulu, North Ostrobothnia, 90220, Finland

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Parkview Research Center at Parkview Regional Medical Center ( Site 0003)
RECRUITING

Fort Wayne, Indiana, 46845, United States

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Princess Margaret Cancer Centre ( Site 0518)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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Pôle Santé Léonard de Vinci ( Site 1112)
RECRUITING

Chambray-lès-Tours, Indre-et-Loire, 37170, France

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ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2801)
RECRUITING

London, London, City of, SW3 6JJ, United Kingdom

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Ramathibodi Hospital ( Site 3402)
RECRUITING

Bangkok, Bangkok, 10400, Thailand

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Rambam Health Care Campus ( Site 1402)
RECRUITING

Haifa, 3109601, Israel

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Rigshospitalet ( Site 0904)
RECRUITING

Copenhagen, Capital Region, 2100, Denmark

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Royal Marsden Hospital (Sutton) ( Site 2802)
RECRUITING

Sutton, London, City of, SM2 5PT, United Kingdom

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Rutgers Cancer Institute of New Jersey ( Site 0071)
RECRUITING

New Brunswick, New Jersey, 08901, United States

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S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2211)
RECRUITING

Craiova, Dolj, 200746, Romania

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Sainte Catherine Institut du Cancer Avignon Provence ( Site 1105)
RECRUITING

Avignon, Vaucluse, 84918, France

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Saitama Medical University International Medical Center ( Site 1632)
RECRUITING

Hidaka, Saitama, 350-1298, Japan

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Samsung Medical Center ( Site 2303)
RECRUITING

Seoul, 06351, South Korea

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Sarasota Memorial Hospital ( Site 0075)
RECRUITING

Sarasota, Florida, 34239, United States

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Seoul National University Hospital ( Site 2301)
RECRUITING

Seoul, 03080, South Korea

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Servicios de Oncología Médica Integral - Monterrey ( Site 1712)
RECRUITING

Monterrey, Nuevo León, 66220, Mexico

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Severance Hospital ( Site 2302)
RECRUITING

Seodaemun-Gu, Seoul, 03722, South Korea

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Shaare Zedek Medical Center ( Site 1405)
RECRUITING

Jerusalem, 9103102, Israel

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Sheba Medical Center ( Site 1401)
RECRUITING

Ramat Gan, 5265601, Israel

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Spitalul Clinic Filantropia ( Site 2213)
RECRUITING

Bucharest, 011132, Romania

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St James Hospital ( Site 1301)
RECRUITING

Dublin, DO8 NHY1, Ireland

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St. Dominic's Hospital ( Site 0064)
ACTIVE_NOT_RECRUITING

Jackson, Mississippi, 39216, United States
Swietokrzyskie Centrum Onkologii. ( Site 2105)
RECRUITING

Kielce, Świętokrzyskie Voivodeship, 25-734, Poland

Contact Phone: •••-•••-••••
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 3924)
RECRUITING

Szeged, Csongrád megye, 6720, Hungary

Contact Phone: •••-•••-••••
Taichung Veterans General Hospital ( Site 2603)
RECRUITING

Taichung, 40705, Taiwan

Contact Phone: •••-•••-••••
Tampereen yliopistollinen sairaala ( Site 1002)
RECRUITING

Tampere, Pirkanmaa, 33520, Finland

Contact Phone: •••-•••-••••
Texas Oncology - Central/South Texas ( Site 8009)
RECRUITING

Austin, Texas, 78758, United States

Contact Phone: •••-•••-••••
Texas Oncology - DFW ( Site 8001)
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Phone: •••-•••-••••
Texas Oncology - Gulf Coast ( Site 8003)
RECRUITING

Webster, Texas, 77598, United States

Contact Phone: •••-•••-••••
Texas Oncology - San Antonio ( Site 8005)
RECRUITING

San Antonio, Texas, 78240, United States

Contact Phone: •••-•••-••••
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0054)
RECRUITING

Columbus, Ohio, 43210, United States

Contact Phone: •••-•••-••••
UZ Leuven ( Site 0301)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium

Contact Phone: •••-•••-••••
University of Alabama at Birmingham ( Site 0006)
RECRUITING

Birmingham, Alabama, 35249, United States

Contact Phone: •••-•••-••••
University of Cincinnati Medical Center ( Site 0090)
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Phone: •••-•••-••••
University of New Mexico Comprehensive Cancer Center ( Site 0055)
RECRUITING

Albuquerque, New Mexico, 87131, United States

Contact Phone: •••-•••-••••
Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2106)
RECRUITING

Poznan, Greater Poland Voivodeship, 61-848, Poland

Contact Phone: •••-•••-••••
Vejle Sygehus ( Site 0902)
RECRUITING

Vejle, Region Syddanmark, 7100, Denmark

Contact Phone: •••-•••-••••
Virginia Cancer Specialists (VCS) ( Site 8011)
RECRUITING

Fairfax, Virginia, 22031, United States

Contact Phone: •••-•••-••••
Vseobecna fakultni nemocnice v Praze ( Site 3325)
RECRUITING

Prague, 128 08, Czechia

Contact Phone: •••-•••-••••
Western General Hospital ( Site 2806)
RECRUITING

Edinburgh, Edinburgh, City of, EH4 2XU, United Kingdom

Contact Phone: •••-•••-••••
Winship Cancer Institute of Emory University ( Site 0086)
RECRUITING

Atlanta, Georgia, 30322, United States

Contact Phone: •••-•••-••••
Women & Infants Hospital ( Site 0050)
RECRUITING

Providence, Rhode Island, 02905, United States

Contact Phone: •••-•••-••••
Women's Cancer Care ( Site 0067)
RECRUITING

Covington, Louisiana, 70433, United States

Contact Phone: •••-•••-••••
Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0001)
RECRUITING

New Haven, Connecticut, 06510, United States

Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

FALLOPIAN TUBE CANCER OVARIAN CANCER PRIMARY PERITONEAL CANCER