New hope for hard-to-treat lung cancer: combo therapy enters human testing
NCT ID NCT06816992
First seen Apr 24, 2026 · Last updated May 14, 2026 · Updated 3 times
Summary
This early-phase study tests a new drug (ORIC-114) combined with an existing targeted therapy (amivantamab) in about 76 people with advanced lung cancer that has a specific genetic change (EGFR exon20 insertion). The goal is to find the safest dose and see if the combination can shrink tumors or slow cancer growth. Participants must have this specific mutation and may have had prior chemotherapy or be newly diagnosed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Peter MacCallum Cancer Centre
NOT_YET_RECRUITINGMelbourne, Victoria, 03000, Australia
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The Princess Margaret Hospital
NOT_YET_RECRUITINGToronto, Ontario, M5G 1Z5, Canada
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
Conditions
Explore the condition pages connected to this study.