New oral drug could slow MS progression in major trial

NCT ID NCT07067463

Recruiting now Disease control Sponsor: Zenas BioPharma (USA), LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 07, 2026 · Updated 22 times

Summary

This phase 3 trial tests whether the oral drug orelabrutinib can slow disability progression in people with primary progressive multiple sclerosis (PPMS). About 705 adults aged 18–60 with PPMS will receive either orelabrutinib or a placebo for up to 5 years. The study measures time to worsening disability using walking, hand function, and standard disability scales.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Orelabrutinib (a BTK inhibitor taken as a pill)
What this could lead to: If successful, this could provide a new oral treatment option to slow disability progression in people with primary progressive multiple sclerosis.
What could go wrong: This is a large phase 3 trial, but the drug may not prove effective or could have side effects. The study lasts up to 5 years, and results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis primary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS (MS) PRIMARY PROGRESSIVE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Arizona Neuroscience Research, LLC
RECRUITING

Pheonix, Arizona, 85032, United States
Astra Clinic (Clinic4U)
RECRUITING

Tallinn, Harju, 10617, Estonia
Avis Medica Hospital Pleven
RECRUITING

Pleven, 5800, Bulgaria
Centrum Medyczne NeuroProtect
RECRUITING

Warsaw, 01-684, Poland
Centrum Medyczne ProNeuro Żory
RECRUITING

Żory, 44-240, Poland
ClinHouse Centrum Medyczne
RECRUITING

Zabrze, Pl-sl, 41-807, Poland
Clinical Centre Kragujevac, Neurology clinic
RECRUITING

Kragujevac, 34000, Serbia
Complejo Hospitalario Universitario A Coruna
RECRUITING

A Coruña, 15006, Spain
Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07039, United States
Copernicus Podmiot Leczniczy Szpital im. M. Kopernika
RECRUITING

Gdansk, 80-803, Poland
Diagnostic and Consultative Center Convex
RECRUITING

Sofia, Sofia, 1680, Bulgaria
Euromedis Osrodek Badan Klinicznych
RECRUITING

Szczecin, 70-111, Poland
Galen Clinic
RECRUITING

Lublin, 20-064, Poland
Hospital Alvaro Cunqueiro
RECRUITING

Vigo, Galicia, 36312, Spain
Hospital Vithas Nisa Sevilla
RECRUITING

Castilleja de la Cuesta, Seville, 41950, Spain
IRCCS Istituto Neurologico Mediterraneo Neuromed
RECRUITING

Pozzilli, Isemiaa/Molise, 86077, Italy
KC Research Center, PA Neurology Research Department
RECRUITING

Roeland Park, Kansas, 66205, United States
Klinicki Bolnicki Centar Zagreb-Rebro
RECRUITING

Zagreb, 10 000, Croatia
Lone Star Neurology
RECRUITING

San Antonio, Texas, 78258, United States
MD Georgia Staff Physician MediClub Georgia
RECRUITING

Tbilisi, Saburtalo, 0160, Georgia
Malva Trials
RECRUITING

Lublin, 20-601, Poland
Medical Center Nevrocentrum
RECRUITING

Plovdiv, Plovdiv, 4000, Bulgaria
NEUROHK, s.r.o.
RECRUITING

Choceň, 56501, Czechia
NNLE Jo Ann University Hospital
RECRUITING

Tbilisi, 0159, Georgia
NZOZ Neuromed M. i M. Nastaj Sp.P
RECRUITING

Lublin, 20-064, Poland
NZOZ Novo Med
RECRUITING

Katowice, Silesian Voivodeship, 40-584, Poland
Neuro Centrum Science Gmbh Albert-Schwitzer
RECRUITING

Erbach im Odenwald, Hesse, 64711, Germany
Neurology Associates, PA
RECRUITING

Maitland, Florida, 32751, United States
Neurology Clinic, P.C.
RECRUITING

Cordova, Tennessee, 38018, United States
Nmedis sp.z o.o.
RECRUITING

Rzeszów, 35-323, Poland
Nova Clinical Research, LLC
RECRUITING

Bradenton, Florida, 34209, United States
Nzoz Neuro-Kard Ilkowski I Partnerzy Spolka Partnerska Lekarzy
RECRUITING

Poznan, Wielkopolska, 61-853, Poland
Perseverance Research Center
RECRUITING

Scottsdale, Arizona, 85253, United States
Premier Neurology
RECRUITING

Greenville, South Carolina, 29605, United States
Raymann, LLC
RECRUITING

Tbilisi, 0186, Georgia
Regina Berkovich MD, PhD Inc.
RECRUITING

West Hollywood, California, 90048, United States
Spital Clinic CF Constanta
RECRUITING

Constanța, Constanța County, 900123, Romania
Texas Institute for Neurological Disorders
RECRUITING

Sherman, Texas, 75092, United States
The Boster Center for Multiple Sclerosis
RECRUITING

Columbus, Ohio, 43235, United States
Twoja Przychodnia Centrum Medyczne Nowa Sol
RECRUITING

Nowa Sól, 67-100, Poland
Twoja Przychodnia PCM
RECRUITING

Poznan, Wielkopolska, 60-324, Poland
University Clinical Centre of Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Centre of Serbia
RECRUITING

Belgrade, 11000, Serbia
Velocity Clinical Research, Raleigh Neurology
RECRUITING

Raleigh, North Carolina, 27607, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Zuyderland Medisch Centrum - Sittard-Geleen
RECRUITING

Sittard, Limburg, 6162-BG, Netherlands

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