New pill aims to halt MS progression in landmark trial
NCT ID NCT07067463
First seen Dec 11, 2025 · Last updated May 20, 2026 · Updated 21 times
Summary
This study tests whether a daily medication called orelabrutinib can slow or prevent worsening disability in people with primary progressive multiple sclerosis (PPMS), a form of MS that steadily gets worse over time. About 705 adults aged 18 to 60 with PPMS and recent disability progression will be randomly assigned to receive either orelabrutinib or a placebo for at least 12 months. The main goal is to see if the drug delays confirmed disability progression, measured by walking speed, hand function, and standard disability scales.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Lone Star Neurology
RECRUITINGSan Antonio, Texas, 78258, United States
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Neurology Associates, PA
RECRUITINGMaitland, Florida, 32751, United States
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Neurology Clinic, P.C.
RECRUITINGCordova, Tennessee, 38018, United States
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Nova Clinical Research, LLC
RECRUITINGBradenton, Florida, 34209, United States
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Perseverance Research Center
RECRUITINGScottsdale, Arizona, 85253, United States
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Premier Neurology
RECRUITINGGreenville, South Carolina, 29605, United States
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Texas Institute for Neurological Disorders
RECRUITINGSherman, Texas, 75092, United States
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Velocity Clinical Research, Raleigh Neurology
RECRUITINGRaleigh, North Carolina, 27607, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Conditions
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