New hope for slowing progressive MS: phase 3 trial launches
NCT ID NCT07299019
First seen Jan 06, 2026 · Last updated May 20, 2026 · Updated 20 times
Summary
This phase 3 trial tests whether the drug orelabrutinib can slow disability progression in people with non-active secondary progressive multiple sclerosis (SPMS). About 990 adults aged 18-60 will be randomly assigned to receive either orelabrutinib or a placebo for 12 to 60 months. The main goal is to see if the drug delays worsening of physical disability, as measured by standard MS scales.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Boston Clinical Trials
WITHDRAWNBoston, Massachusetts, 02131, United States
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Lone Star Neurology
RECRUITINGSan Antonio, Texas, 78258, United States
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Neurology Associates
RECRUITINGMaitland, Florida, 32751, United States
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Nova Clinical Research, LLC
RECRUITINGBradenton, Florida, 34209, United States
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Perseverance Research Center, LLC (PRC)
RECRUITINGScottsdale, Arizona, 85253, United States
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Profound Research LLC at Oakland Neurology Center
RECRUITINGRochester Hills, Michigan, 48307, United States
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Texas Institute for Neurological Disorders - Sherman
RECRUITINGSherman, Texas, 75092, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Conditions
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