New pill could stop painful swelling attacks in rare disease

NCT ID NCT04618211

First seen Jan 11, 2026 · Last updated Apr 30, 2026 · Updated 17 times

Summary

This study tested an oral medication called deucrictibant for quickly relieving symptoms of hereditary angioedema (HAE) attacks, such as skin swelling, skin pain, and belly pain. 74 adults with HAE types I or II took either one of three doses of the drug or a placebo during an attack. The main goal was to see if the drug reduced symptoms more than placebo within 4 hours.

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Contacts and locations

Locations

  • Study site

    Birmingham, Alabama, 35209, United States

  • Study site

    Paradise Valley, Arizona, 85253, United States

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    San Diego, California, 92122, United States

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    Santa Monica, California, 90404, United States

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    Walnut Creek, California, 94598, United States

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    Chevy Chase, Maryland, 20815, United States

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    St Louis, Missouri, 63141, United States

  • Study site

    Hershey, Pennsylvania, 17033, United States

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    Sofia, Bulgaria

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    Edmonton, Alberta, Canada

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    Ottawa, Ontario, Canada

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    Toronto, Ontario, Canada

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    Montreal, Quebec, Canada

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    Québec, Quebec, Canada

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    Brno, Czechia

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    Hradec Králové, Czechia

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    Grenoble, France

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    Montpellier, France

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    Paris, France

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    Berlin, Germany

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    Dresden, Germany

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    Frankfurt, Germany

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    Mainz, Germany

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    Ulm, Germany

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    Budapest, Hungary

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    Ashkelon, Israel

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    Haifa, Israel

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    Tel Aviv, Israel

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    Monserrato, Italy

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    Naples, Italy

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    Amsterdam, Netherlands

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    Krakow, Poland

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    Barcelona, Spain

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    Madrid, Spain

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    Brighton, United Kingdom

  • Study site

    London, United Kingdom

Conditions

Explore the condition pages connected to this study.