Knee surgery pain relief gets a precision upgrade: new trial tests optimal dose
NCT ID NCT06942689
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests different volumes of liposomal bupivacaine, a long-acting painkiller, injected near the nerve in the thigh to numb the knee during surgery. The goal is to find the dose that provides good pain control while minimizing leg muscle weakness. Sixty-three adults having knee surgery will receive one of several volumes, and researchers will measure pain scores and muscle strength. The results could lead to more personalized and effective pain management after knee procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liposomal bupivacaine
What this could lead to
If successful, this could provide a precise dosing guide for longer-lasting pain relief after knee surgery with less muscle weakness.
What could go wrong
This is a small, early-phase trial (63 people) focused on dosing, not on proving long-term benefits. The results may not apply to all patients or surgeries.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Nanjing First Hospital
RECRUITINGNanjing, Jiangsu, 210006, China
Contact Phone: •••-•••-•••• Email: •••••@•••••