Yearly HIV prevention shot could change the game

NCT ID NCT07047716

Ongoing Prevention Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new shot called lenacapavir, given once a year, to see if it can safely prevent HIV in people at risk. About 350 participants will receive the injection and be monitored for side effects and drug levels. If successful, this could offer a much more convenient option than daily pills or frequent injections.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV PRE-EXPOSURE PROPHYLAXIS

Contacts and locations

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Locations

BIOS Clinical Research

Palm Springs, California, 92262, United States
Be Well Medical Center

Berkley, Michigan, 48072, United States
Bridge HIV, San Francisco Department of Public Health

San Francisco, California, 94102, United States
Central Texas Clinical Research

Austin, Texas, 78705, United States
Children's National Hospital

Washington D.C., District of Columbia, 20010, United States
Fenway Health

Boston, Massachusetts, 02215, United States
Howard Brown Health Center

Chicago, Illinois, 60613, United States
ICAP at Columbia University- Bronx Prevention Center

The Bronx, New York, 10451, United States
Icahn School of Medicine at Mount Sinai - Clinical and Translational Research Center

New York, New York, 10029, United States
Johns Hopkins Hospital - Clinical Research Unit

Baltimore, Maryland, 21287, United States
Midway Immunology and Research Center

Ft. Pierce, Florida, 34982, United States
Mills Clinical Research

Los Angeles, California, 90069, United States
NC TraCS Institute - CTRC, University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
Penn Prevention Unit

Philadelphia, Pennsylvania, 19104, United States
Philadelphia FIGHT Community Health Centers, Jonathan Lax Treatment Center

Philadelphia, Pennsylvania, 19107, United States
Ponce de Leon Center Clinical Research Site

Atlanta, Georgia, 30303, United States
Ruane Clinical Research Group, Inc.

Los Angeles, California, 90036, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
The Crofoot Research Center

Houston, Texas, 77098, United States
The Hope Clinic of Emory University

Atlanta, Georgia, 30030, United States
The ID Prevention Research Unit

Miami, Florida, 33136, United States
UAB Sexual Health Research Clinic

Birmingham, Alabama, 35233, United States
UCLA Clinic Care

Los Angeles, California, 90035, United States
UCLA Vine Street Clinic

Los Angeles, California, 90038, United States
UCSD AntiViral Research Center (AVRC)

San Diego, California, 92103, United States
University Medical Center

New Orleans, Louisiana, 70119, United States
University of Illinois-Chicago (UIC), Center for Dissemination and Implementation Sciences (CDIS)

Chicago, Illinois, 60612, United States
University of South Florida - Curran Children's Health Center

Tampa, Florida, 33606, United States
Vaccine Trials Unit - Fred Hutchinson Cancer Center / University of Washington

Seattle, Washington, 98104, United States
Whitman-Walker Institute, Inc.

Washington D.C., District of Columbia, 20009, United States
Yale University; School of Medicine; AIDS Program

New Haven, Connecticut, 06510, United States

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