New hope for tough lung cancers: Next-Gen drug trial seeks to extend lives

NCT ID NCT05671510

Recruiting now Disease control Sponsor: OncoC4, Inc. Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is testing whether a new immunotherapy drug called gotistobart (ONC-392) can help people live longer than standard chemotherapy for a specific type of advanced lung cancer. It is for adults whose metastatic non-small cell lung cancer has continued to grow despite receiving common immunotherapies (PD-1/PD-L1 inhibitors). About 630 participants will be randomly assigned to receive either the new drug or the chemotherapy docetaxel through an IV every three weeks.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AOU Policlinico Giaccone, Università di Palermo - 2309
RECRUITING

Palermo, 90129, Italy

Contact
AZ Maria Middelares - 2104
RECRUITING

Ghent, 9000, Belgium

Contact
Adana Sehir Hastanesi - 2602
RECRUITING

Adana, Turkey (Türkiye)

Contact
AdventHealth Cancer Institute - 1105
RECRUITING

Orlando, Florida, 32804, United States

Contact
Affiliated Hospital of Hebei University - 3214
COMPLETED

Zhengzhou, Hebei, 71000, China
Akdeniz University Medical Hospital - 2606
RECRUITING

Antalya, Turkey (Türkiye)

Contact
Anhui Medical University - The Second Hospital - 3222
COMPLETED

Hefei, Anhui, 231200, China
Ankara Bilkent Sehir Hastanesi - 2610
RECRUITING

Ankara, 06800, Turkey (Türkiye)

Contact
Antoni van Leeuwenhoek - 2703
RECRUITING

Amsterdam, 1066 CV, Netherlands

Contact
Asan Medical Centre - 3103
RECRUITING

Seoul, 05505, South Korea

Contact
Asklepios Fachkliniken Muenchen-Gauting - 2203
RECRUITING

Muenchen-Gauting, 82131, Germany

Contact
Astera Cancer Care - 1128
RECRUITING

East Brunswick, New Jersey, 08816, United States

Contact
Azienda Ospedaliera Universitaria "Federico II" - 2304
RECRUITING

Naples, 80131, Italy

Contact
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - 2310
RECRUITING

Bergamo, 24126, Italy

Contact
BC Cancer Centre - Kelowna - 1203
RECRUITING

Kelowna, British Columbia, Canada

Contact
Bankstown Hospital - 3305
NOT_YET_RECRUITING

Bankstown, New South Wales, 2200, Australia
Barts Health NHS Trust (St. Bartholomew's Hospital) - 2803
RECRUITING

London, England, EC1A 7BE, United Kingdom

Contact
Baskent University Adana - 2601
RECRUITING

Adana, Turkey (Türkiye)

Contact
Bass Medical Group - 1155
RECRUITING

Walnut Creek, California, 94598, United States

Contact
Beijing Cancer Hospital - 3205
COMPLETED

Beijing, Beijing Municipality, China
C. H. R. de la Citadelle - 2103
RECRUITING

Liège, 4000, Belgium

Contact
Cambridge University Hospitals - 2804
RECRUITING

Cambridge, England, CB2 0QQ, United Kingdom

Contact
Cancer Care Associates of York, Inc. - 1113
RECRUITING

York, Pennsylvania, 17403, United States

Contact
Cancer Hospital, Chinese Academy of Medical Sciences - 3211
COMPLETED

Beijing, Beijing Municipality, China
Cancer Research SA - 3303
COMPLETED

Adelaide, South Australia, 5000, Australia
Chengdu Seventh People's Hospital - 3229
COMPLETED

Chengdu, Sichuan, 610041, China
China-Japan Friendship Hospital - 3236
COMPLETED

Beijing, 100029, China
Chongqing University Cancer Hospital - 3213
COMPLETED

Chongqing, Sichuan, China
Chungbuk National University Hospital - 3101
RECRUITING

Cheongju-si, 28644, South Korea

Contact
Clinica Oncologica Ospedali Riuniti Ancona - 2311
RECRUITING

Ancona, 60126, Italy

Contact
Cotton O'Neil Clinical Research Center - 1151
RECRUITING

Topeka, Kansas, 66606, United States

Contact
D&H Cancer Research Center LLC - 1153
RECRUITING

Margate, Florida, 33063, United States

Contact
Deaconess Chancellor Center for Oncology - 1131
RECRUITING

Newburgh, Indiana, 47630, United States

Contact
Donald Guthrie Foundation - 1135
RECRUITING

Sayre, Pennsylvania, 18840, United States

Contact
Dongguan People's Hospital - 3206
COMPLETED

Dongguan, Guangdong, China
Duke University Medical Center - 1158
RECRUITING

Durham, North Carolina, 27710, United States

Contact
ETZ Elisabeth - 2704
RECRUITING

Tilburg, 5022 GC, Netherlands

Contact
Edinburgh Cancer Centre - 2809
RECRUITING

Edinburgh, Scotland, EH54 6PP, United Kingdom

Contact
Emad Ibrahim MD Inc. - 1147
RECRUITING

Redlands, California, 92373, United States

Contact
Florida Cancer Specialists -East - 1124
RECRUITING

West Palm Beach, Florida, 33401, United States

Contact
Florida Cancer Specialists -North - 1125
RECRUITING

The Villages, Florida, 32159, United States

Contact
Florida Cancer Specialists -South - 1126
RECRUITING

Sarasota, Florida, 34232, United States

Contact
Fondazione IRCCS Instituto Tumori Di Milano - 2305
NOT_YET_RECRUITING

Milan, 20133, Italy

Contact
Fort Wayne Medical Oncology - 1133
RECRUITING

Fort Wayne, Indiana, 46805, United States

Contact
Fujian Medical University Union Hospital - 3225
COMPLETED

Fuzhou, Fujian, China
Fundacion Instituto Valenciano De Oncologia (IVO) - 2402
RECRUITING

Valencia, 56009, Spain

Contact
Genesis Cancer and Blood Institute - 1123
RECRUITING

Russellville, Arkansas, 72801, United States

Contact
Guangdong Provincial People's Hospital - 3201
COMPLETED

Guangzhou, Guangdong, 510105, China
Göztepe Prof Dr. Suleyman Yalcin City Hospital - 2605
RECRUITING

Istanbul, Turkey (Türkiye)

Contact
Hacettepe Universitesi - 2609
RECRUITING

Ankara, 06230, Turkey (Türkiye)

Contact
Hainan General Hospital - 3202
COMPLETED

Haikou, Hainan, China
Henan Cancer Hospital - 3226
COMPLETED

Zhengzhou, Henan, 450008, China
Hospital General Universitario Gregorio Marañon - 2404
RECRUITING

Madrid, 28007, Spain

Contact
Hospital General Universitario de Elche - 2401
RECRUITING

Elche, 03203, Spain

Contact
Hospital General Universitario de Valencia - 2406
RECRUITING

Valencia, 46014, Spain

Contact
Hospital Regional Universitario de Malaga - 2403
RECRUITING

Málaga, 29010, Spain

Contact
Hospital Universitario Lucus Augusti - 2405
RECRUITING

Lugo, 27003, Spain

Contact
Hubei Cancer Hospital - 3237
COMPLETED

Wuhan, 430079, China
Humanitas Istituto Clinico Catanese - 2312
RECRUITING

Catania, 95045, Italy

Contact
Hunan Cancer Hospital - 3209
COMPLETED

Changsha, Hunan, China
IRCCS Istituto Tumori Giovanni Paolo II - 2306
RECRUITING

Bari, 70124, Italy

Contact
Istanbul Bakirkoy Sadi Konuk - 2604
RECRUITING

Istanbul, Turkey (Türkiye)

Contact
Istanbul Üniversitesi Onkoloji Enstitüsü - 2613
RECRUITING

Fatih, 34093, Turkey (Türkiye)

Contact
Izmir Ekonomi Universitesi Medical Point Hastanesi - 2607
RECRUITING

Izmir, Turkey (Türkiye)

Contact
Jefferson City Medical Group - 1145
RECRUITING

Jefferson City, Missouri, 65109, United States

Contact
Jessa Ziekenhuis (Jessa Hospital) - Campus Salvator - 2102
RECRUITING

Hasselt, 3500, Belgium

Contact
Jinan Central Hospital - 3230
COMPLETED

Jinan, Shandong, 250013, China
Keimyung University Dongsan Hospital - 3102
RECRUITING

Daegu, 42601, South Korea

Contact
Kliniken Essen-Mitte - 2206
RECRUITING

Essen, 45136, Germany

Contact
Klinikum Esslingen GmbH - 2201
RECRUITING

Esslingen am Neckar, 73730, Germany

Contact
Klinikverbund Allgaü - Klinikum Kempten - 2205
RECRUITING

Immenstädt, 87509, Germany

Contact
Koc Universitesi - 2611
RECRUITING

Istanbul, 34010, Turkey (Türkiye)

Contact
Korea University Guro Hospital - 3106
RECRUITING

Seoul, 08308, South Korea

Contact
Lungenfachklinik Immenhausen - 2202
RECRUITING

Immenhausen, 34376, Germany

Contact
Mater - 3301
NOT_YET_RECRUITING

Newstead, Queensland, 4006, Australia
Medipol University Medical Faculty Hospital - 2603
RECRUITING

Istanbul, Turkey (Türkiye)

Contact
Miami Valley Hospital - 1115
RECRUITING

Centerville, Ohio, 45459, United States

Contact
MidAmerica Cancer Care - 1163
RECRUITING

Kansas City, Missouri, 64132, United States

Contact
NEXT Oncology - Virginia - 1129
RECRUITING

Fairfax, Virginia, 22031, United States

Contact
Nanjing Medical University (NMU) - Nanjing First Hospital - 3239
COMPLETED

Jiangse, 21006, China
National Cancer Center - 3107
RECRUITING

Goyang-si, 10408, South Korea

Contact
Norton Cancer Institute - 1108
RECRUITING

Louisville, Kentucky, 40202, United States

Contact
Nuvance Health - 1118
RECRUITING

Norwalk, Connecticut, 06850, United States

Contact
Ocala Oncology Center PL - 1102
RECRUITING

Ocala, Florida, 34474, United States

Contact
Oklahoma Cancer Specialists and Research Institute - 1154
RECRUITING

Tulsa, Oklahoma, 74146, United States

Contact
Oncology Associates of Oregon - 1138
RECRUITING

Eugene, Oregon, 97401, United States

Contact
Oncology Consultants, P.A. - 1120
RECRUITING

Houston, Texas, 77024, United States

Contact
Oncology and Hematology of South Texas - 1165
RECRUITING

Laredo, Texas, 78041, United States

Contact
Orchard Healthcare Research, Inc. - 1116
RECRUITING

Skokie, Illinois, 60077, United States

Contact
Orlando Health - 1130
RECRUITING

Orlando, Florida, 32806, United States

Contact
Ospedale San Gerardo di Monza - 2302
RECRUITING

Monza, 20900, Italy

Contact
Ospedale San Raffaele - 2307
RECRUITING

Milan, 20132, Italy

Contact
Renmin Hospital of Wuhan University - 3216
COMPLETED

Wuhan, Hubei, China
Rijnstate Ziekenhuis - 2701
RECRUITING

Arnhem, 6815, Netherlands

Contact
Royal Devon University Healthcare NHS - 2808
NOT_YET_RECRUITING

Exeter, England, EX25DW, United Kingdom

Contact
Sarah Cannon Research Institute - Tennessee Oncology at Nashville - 1119
RECRUITING

Nashville, Tennessee, 37203, United States

Contact
Saskatchewan Cancer Agency - Regina - 1201
RECRUITING

Regina, Saskatchewan, S4T 7T1, Canada

Contact
Saskatchewan Cancer Agency - Saskatoon Cancer Centre - 1202
RECRUITING

Saskatoon, Saskatchewan, S7N 4H4, Canada

Contact
Severance Hospital, Yonsei University Health System - 3104
RECRUITING

Seoul, 03722, South Korea

Contact
Shanxi Bethune Hospital - 3233
COMPLETED

Taiyuan, Shanxi, 30032, China
Sichuan Cancer Hospital - 3227
COMPLETED

Chengdu, Sichuan, 610041, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine - 3219
COMPLETED

Hangzhou, Zhejiang, China
South Tees Hospitals - 2807
RECRUITING

Middlesbrough, England, TS4 3BW, United Kingdom

Contact
Springfield Clinic - The Cancer Center - 1110
RECRUITING

Springfield, Illinois, 62702, United States

Contact
St. Luke's University Health Network - 1179
RECRUITING

Bethlehem, Pennsylvania, 18015, United States

Contact
Städt. Klinikum München GmbH - 2204
RECRUITING

Bogenhausen, 81925, Germany

Contact
Texas Oncology - Baylor Charles A. Sammons Cancer Center (USOR) - 1140
RECRUITING

Dallas, Texas, 75246, United States

Contact
Texas Oncology - Denison - 1139
RECRUITING

Denison, Texas, 75020, United States

Contact
Texas Oncology - McAllen - 1132
RECRUITING

McAllen, Texas, 78503, United States

Contact
Texas Oncology -San Antonio - 1122
RECRUITING

San Antonio, Texas, 78240, United States

Contact
The Affiliated Tumor Hospital of Harbin Medical University - 3232
COMPLETED

Harbin, Heilongjiang, 150040, China
The Catholic University of Korea, St Vincent's Hospital - 3105
RECRUITING

Suwon, 16247, South Korea

Contact
The Christie NHS Foundation Trust - 2802
RECRUITING

Manchester, London, M20 4BX, United Kingdom

Contact
The First Affiliated Hospital of Anhui Medical University - 3221
COMPLETED

Hefei, Anhui, 230022, China
The First Affiliated Hospital of Guangdong Pharmaceutical University - 3215
COMPLETED

Guangzhou, Guangdong, China
The First Affiliated Hospital of Xi'an Jiaotong University - 3218
COMPLETED

Xi’an, Shanxi, China
The First Affiliated Hospital of Xiamen University - 3210
COMPLETED

Xiamen, Fujian, China
The First Affliated Hospital of Zhengzhou University - 3207
COMPLETED

Zhengzhou, Henan, China
The Ohio State University James Cancer Center - 1104
RECRUITING

Columbus, Ohio, 43210, United States

Contact
The Oncology Institute (TOI) Clinical Research - 1109
RECRUITING

Cerritos, California, 90703, United States

Contact
The People's Hospital of Guangxi Zhuang Autonomous Region - 3228
COMPLETED

Nanning, Guangxi, 530021, China
The Second Affiliated Hospital of Nanchang University - 3224
COMPLETED

Nanchang, Jiangxi, 330006, China
The Second Affiliated Hospital of Soochow University - 3217
COMPLETED

Suzhou, Jiangsu, China
The Second Affiliated Hospital of Zhejiang University School of Medicine - 3220
COMPLETED

Hangzhou, Zhejiang, China
Tianjin Medical University Cancer Institute and Hospital - 3208
COMPLETED

Tianjin, Tianjin Municipality, China
Tongji University - Shanghai Oriental Hospital (Shanghai East Hospital) - 3240
COMPLETED

Shanghai, 200120, China
Torbay and South Devon NHS Foundation Trust - 2805
RECRUITING

Torquay, England, TQ2 7AA, United Kingdom

Contact
Trakya University Faculty of Medicine Edirne - 2608
RECRUITING

Edirne, Turkey (Türkiye)

Contact
Tri County Hematology & Oncology Associates, Inc - 1156
RECRUITING

Massillon, Ohio, 44646, United States

Contact
UC Davis Comprehensive Cancer Center - 1103
RECRUITING

Sacramento, California, 95817, United States

Contact
Union Hospital Tongji Medical College - 3212
COMPLETED

Wuhan, Hubei, China
Universita Campus Bio-medico Di Roma (UCBM) - Policlinico Universitario - 2303
RECRUITING

Roma, 00128, Italy

Contact
Universita degli Studi di Perugia - Ospedale Santa Maria della Misericordia - 2308
RECRUITING

Perugia, 06132, Italy

Contact
University College London Hospital - 2811
RECRUITING

London, NW1 2PG, United Kingdom

Contact
University Hospital Birmingham (UHB) / Queen Elizabeth Hospital Birmingham - 2801
RECRUITING

Birmingham, England, B15 2TG, United Kingdom

Contact
University Hospital Leicester - 2806
RECRUITING

Leicester, England, LE1 5WW, United Kingdom

Contact
University of Cincinnati Cancer Center - 1107
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact
University of Kentucky - Markey Cancer Center - 1112
RECRUITING

Lexington, Kentucky, 40536, United States

Contact
University of Tennessee Medical Center - 1146
RECRUITING

Knoxville, Tennessee, 37920, United States

Contact
Virginia Cancer Institute - 1149
RECRUITING

Henrico, Virginia, 23226, United States

Contact
Virginia Oncology Associates - 1136
RECRUITING

Norfolk, Virginia, 23502, United States

Contact
Vitaz - Sint-niklaas Moerland - 2101
RECRUITING

Sint-Niklaas, 9100, Belgium

Contact
Weifang Second People's Hospital - 3235
COMPLETED

Shandong, 261041, China
West China Hospital, Sichuan University - 3238
COMPLETED

Chengdu, 610041, China
West Virginia University Cancer Institute - 1172
RECRUITING

Morgantown, West Virginia, 26505, United States

Contact
Western Health - Sunshine Hospital - 3307
NOT_YET_RECRUITING

St Albans, Victoria, 3021, Australia

Contact
XCancer/Dothan Hematology & Oncology - 1114
RECRUITING

Dothan, Alabama, 36303, United States

Contact
Xiangya Hospital, Central South University - 3223
COMPLETED

Changsha, Hunan, 410008, China
Xuzhou Medical University - The Affiliated Hospital - 3234
COMPLETED

Xuzhou, Jiangsu, 221002, China
Yunnan Cancer Hospital - 3231
COMPLETED

Kunming, Yunnan, 650118, China
Zhejiang Cancer Hospital - 3204
COMPLETED

Hangzhou, Zhejiang, China
Zhujiang Hospital of Southern Medical University - 3203
COMPLETED

Guangzhou, Guangdong, 510280, China

Conditions

Explore the condition pages connected to this study.

NON SMALL CELL LUNG CANCER