New hope for leukemia patients: phase 3 trial of olverembatinib combo launches

NCT ID NCT06051409

Recruiting now Disease control Sponsor: Ascentage Pharma Group Inc. Source: ClinicalTrials.gov ↗

First seen May 13, 2026 · Last updated May 13, 2026

Summary

This phase 3 trial tests whether a new targeted drug (olverembatinib) combined with chemotherapy works better than other standard targeted drugs plus chemotherapy for adults newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). About 350 participants will be randomly assigned to one of the two treatment groups. The main goal is to see if the new combination leads to a deeper remission (no cancer cells detectable) and longer survival without the disease coming back.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Alfred Health
ACTIVE_NOT_RECRUITING

Melbourne, Victoria, 3004, Australia
Ascentage Investigative Site #1044
NOT_YET_RECRUITING

Birmingham, Alabama, 35233, United States
Ascentage Investigative Site #1045
NOT_YET_RECRUITING

Augusta, Georgia, 30912, United States
Ascentage Investigative Site #1059
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
Ascentage Investigative Site #1062
NOT_YET_RECRUITING

Duarte, California, 91010, United States
Ascentage Investigative Site #1064
NOT_YET_RECRUITING

Hackensack, New Jersey, 07601, United States
Ascentage Investigative Site #1069
NOT_YET_RECRUITING

Indianapolis, Indiana, 46237, United States
Ascentage Investigative Site #1084
NOT_YET_RECRUITING

Lexington, Kentucky, 40536, United States
Ascentage Investigative Site #1098
NOT_YET_RECRUITING

New Brunswick, New Jersey, 08901, United States
Ascentage Investigative Site #1134
NOT_YET_RECRUITING

Los Angeles, California, 90048, United States
Ascentage Investigative Site #1142
NOT_YET_RECRUITING

Miami, Florida, 33155, United States
Ascentage Investigative Site #1151
NOT_YET_RECRUITING

The Bronx, New York, 10461, United States
Ascentage Investigative Site #1155
NOT_YET_RECRUITING

Morgantown, West Virginia, 26506, United States
Ascentage Investigative Site #1158
NOT_YET_RECRUITING

Indianapolis, Indiana, 46202, United States
Ascentage Investigative Site #1160
NOT_YET_RECRUITING

Stony Brook, New York, 11794, United States
Ascentage Investigative Site #1501
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Ascentage Investigative Site #1806
NOT_YET_RECRUITING

Seattle, Washington, 98104, United States
Ascentage Investigative Site #5013
NOT_YET_RECRUITING

Nantes, 44000, France
Ascentage Investigative Site #5018
NOT_YET_RECRUITING

Toulouse, 31059, France
Ascentage Investigative Site #5019
NOT_YET_RECRUITING

Pessac, 33604, France
Ascentage Investigative Site #5020
NOT_YET_RECRUITING

Le Chesnay, 78150, France
Ascentage Investigative Site #5021
NOT_YET_RECRUITING

Lyon, 69008, France
Ascentage Investigative Site #5022
NOT_YET_RECRUITING

Poitiers, 86021, France
Ascentage Investigative Site #5024
NOT_YET_RECRUITING

Pierre-Bénite, 69495, France
Ascentage Investigative Site #5025
NOT_YET_RECRUITING

Nice, 06200, France
Ascentage Investigative Site #5529
NOT_YET_RECRUITING

Meldola, 47014, Italy
Ascentage Investigative Site #5531
NOT_YET_RECRUITING

Roma, 00138, Italy
Ascentage Investigative Site #5533
NOT_YET_RECRUITING

Monza, 20900, Italy
Ascentage Investigative Site #5536
NOT_YET_RECRUITING

Varese, 21100, Italy
Ascentage Investigative Site #5538
NOT_YET_RECRUITING

Bologna, 40138, Italy
Ascentage Investigative Site #5539
NOT_YET_RECRUITING

Milan, 20132, Italy
Ascentage Investigative Site #5540
NOT_YET_RECRUITING

Ravenna, 48121, Italy
Ascentage Investigative Site #5550
NOT_YET_RECRUITING

Torino, 10126, Italy
Ascentage Investigative Site #6011
NOT_YET_RECRUITING

Madrid, 28041, Spain
Ascentage Investigative Site #6013
NOT_YET_RECRUITING

Madrid, 28007, Spain
Ascentage Investigative Site #6016
NOT_YET_RECRUITING

Madrid, 20834, Spain
Ascentage Investigative Site #6017
NOT_YET_RECRUITING

Valencia, 6017, Spain
Ascentage Investigative Site #6018
NOT_YET_RECRUITING

Badalona, 08916, Spain
Ascentage Investigative Site #6019
NOT_YET_RECRUITING

Badalona, 08916, Spain
Ascentage Investigative Site #6020
NOT_YET_RECRUITING

Barcelona, 08035, Spain
Ascentage Investigative Site #6021
NOT_YET_RECRUITING

Santander, 39008, Spain
Ascentage Investigative Site #6035
NOT_YET_RECRUITING

Madrid, 28006, Spain
Ascentage Investigative Site #6048
NOT_YET_RECRUITING

Cáceres, 10003, Spain
Ascentage Investigative Site #6049
NOT_YET_RECRUITING

Madrid, 20840, Spain
Ascentage Investigative Site #6050
NOT_YET_RECRUITING

Seville, 41010, Spain
Ascentage Investigative Site #6302
NOT_YET_RECRUITING

Prague, 10034, Czechia
Ascentage Investigative Site #6304
NOT_YET_RECRUITING

Ostrava, 70852, Czechia
Ascentage Investigative Site #6305
NOT_YET_RECRUITING

Hradec Králové, 50005, Czechia
Ascentage Investigative Site #6309
NOT_YET_RECRUITING

Prague, 12800, Czechia
Ascentage Investigative Site #6502
NOT_YET_RECRUITING

Cluj-Napoca, 400015, Romania
Ascentage Investigative Site #6503
NOT_YET_RECRUITING

Bucharest, 020125, Romania
Ascentage Investigative Site #6504
NOT_YET_RECRUITING

Iași, 700483, Romania
Ascentage Investigative Site #6507
NOT_YET_RECRUITING

Craiova, 200143, Romania
Ascentage Investigative Site #6602
NOT_YET_RECRUITING

Singapore, 119074, Singapore
Ascentage Investigative Site #6603
NOT_YET_RECRUITING

Singapore, 169608, Singapore
Ascentage Investigative Site #6604
NOT_YET_RECRUITING

Singapore, 308433, Singapore
Ascentage Investigative Site #7002
NOT_YET_RECRUITING

Birmingham, B15 2GW, United Kingdom
Ascentage Investigative Site #7019
NOT_YET_RECRUITING

London, SW3 6JJ, United Kingdom
Ascentage Investigative Site #7034
NOT_YET_RECRUITING

Glasgow, G12 0YN, United Kingdom
Ascentage Investigative Site #8201
NOT_YET_RECRUITING

Seoul, 03080, South Korea
Ascentage Investigative Site #8202
NOT_YET_RECRUITING

Seoul, 05505, South Korea
Ascentage Investigative Site #8203
NOT_YET_RECRUITING

Seoul, 06591, South Korea
Ascentage Investigative Site #8206
NOT_YET_RECRUITING

Busan, 49201, South Korea
Ascentage Investigative Site #8207
NOT_YET_RECRUITING

Busan, 49241, South Korea
Ascentage Investigative Site #8208
NOT_YET_RECRUITING

Uijeongbu-si, 11759, South Korea
Ascentage Investigative Site #8647
NOT_YET_RECRUITING

Brno, 62500, Czechia
Ascentage Investigative Site #9201
NOT_YET_RECRUITING

Ankara, 06100, Turkey (Türkiye)
Ascentage Investigative Site #9202
NOT_YET_RECRUITING

Izmir, 35100, Turkey (Türkiye)
Ascentage Investigative Site #9203
NOT_YET_RECRUITING

Istanbul, 34381, Turkey (Türkiye)
Ascentage Investigative Site #9204
NOT_YET_RECRUITING

Ankara, 06170, Turkey (Türkiye)
Ascentage Investigative Site #9205
NOT_YET_RECRUITING

Antalya, 07025, Turkey (Türkiye)
Ascentage Investigative Site #9208
NOT_YET_RECRUITING

Mersin, 33200, Turkey (Türkiye)
Ascentage Investigative Site #9209
NOT_YET_RECRUITING

Ankara, 06560, Turkey (Türkiye)
Ascentage Investigative Site #9210
NOT_YET_RECRUITING

Tekirdağ, 59030, Turkey (Türkiye)
Ascentage Investigative Site #9211
NOT_YET_RECRUITING

Kayseri, 38039, Turkey (Türkiye)
Ascentage Investigative Site #9212
NOT_YET_RECRUITING

Ankara, 06200, Turkey (Türkiye)
Ascentage Investigative Site #9220
NOT_YET_RECRUITING

Samsun, 55139, Turkey (Türkiye)
Guangdong Province People's Hospital
RECRUITING

Guangdong, Guangzhou, 510080, China

Contact

Contact
Henan Cancer Hospital
RECRUITING

Zhengzhou, Henan, 450003, China

Contact

Contact
Institute of Blood Transfusion of Chinese Academy of Medical Sciences
RECRUITING

Tianjin, Tianjin Municipality, 215127, China

Contact

Contact
Nanfang Hospital of Southern Medical University
RECRUITING

Guangdong, Guangzhou, 510515, China

Contact

Contact
Royal Adelaide Hospital
ACTIVE_NOT_RECRUITING

Adelaide, South Australia, 5000, Australia
Royal North Shore Hospital
ACTIVE_NOT_RECRUITING

St Leonards, New South Wales, Australia
Royal Perth Hospital
ACTIVE_NOT_RECRUITING

Perth, Washington, 6000, Australia
Shanghai Jiao Tong University School of Medicine Ruijin Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200025, China

Contact

Contact
The First Affiliated Hospital of Bengbu Medical School
NOT_YET_RECRUITING

Bengbu, Anhui, 233000, China

Contact

Contact
The First Affiliated Hospital of Suzhou University
RECRUITING

Suzhou, Jiangsu, 215006, China

Contact

Contact
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610044, China

Contact

Contact
Wuhan Union Hospital of Tongji Medical College of Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430022, China

Contact

Contact
Xinqiao Hospital of Army Medical University
RECRUITING

Chongqing, Chongqing Municipality, 214426, China

Contact

Contact

Conditions

Explore the condition pages connected to this study.

LEUKEMIA, LYMPHOBLASTIC, ACUTE, PHILADELPHIA-POSITIVE PH+ ALL