New injection aims to tame dangerous blood fats

NCT ID NCT05552326

Summary

This study tested whether a new injectable drug called olezarsen could lower very high triglyceride levels in the blood. It involved 446 adults with severely elevated triglycerides who were already on standard medications. Participants received either olezarsen or a placebo injection for a year to see if the drug safely reduced fat levels and the risk of serious complications like pancreatitis.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 3Sync Research

    Sunrise, Florida, 33325, United States

  • AHEPA Building of Evaggelismos

    Athens, 10676, Greece

  • AHEPA University General Hospital of Thessaloniki

    Thessaloniki, 54636, Greece

  • AORN S. Anna e S. Sebastiano UOC FARMACIA

    Caserta, 81100, Italy

  • AZ Sint-Jan Brugge

    Bruges, 8000, Belgium

  • Acardo MedSite

    Solna, SE-171 64, Sweden

  • Accel Clinical Research

    Eatonton, Georgia, 31024, United States

  • Accel Research Sites

    DeLand, Florida, 32720, United States

  • Acibadem City Clinic Tokuda University Hospital

    Sofia, 1407, Bulgaria

  • AeskuLab k.s

    Teplice, 415 01, Czechia

  • Aggarwal and Associates Ltd.

    Brampton, Ontario, L6T 0G1, Canada

  • Alabama Clinical Therapeutics, LLC Alabaster

    Birmingham, Alabama, 35235, United States

  • Albert Schweitzer Ziekenhuis

    Dordrecht, 3318 AT, Netherlands

  • Alian s.r.o.

    Bardejov, 08501, Slovakia

  • Ambulancia diabetologicka a poruch latkovej premeny a vyzivy

    Bratislava, 83106, Slovakia

  • Areteus s.r.o

    Trebišov, 07501, Slovakia

  • Aspen Clinical Research

    Orem, Utah, 84058, United States

  • Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna

    Cona, 44124, Italy

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

    Bergamo, 24127, Italy

  • B. M. Birla Heart Research Centre A Unit of the Calcutta Medical Research Institute

    Kolkata, West Bengal, 700027, India

  • Bethesda Diabetes Research Center

    Hoogeveen, 7909 AA, Netherlands

  • Bhatia Hospital

    Mumbai, 400007, India

  • Biokinetica

    Józefów, 05-410, Poland

  • Bluewater Clinical Research Group

    Sarnia, Ontario, N7t 4X3, Canada

  • CIPREC - Centro de Investigación y Prevención Cardiovascular

    Buenos Aires, C1061AAG, Argentina

  • CPQuali Pesquisa Clinica

    São Paulo, 01228-000, Brazil

  • CTC Hodonin s.r.o.

    Hodonín, 695 01, Czechia

  • Cabinet Medical Individual SC DIANA BARBONTA SRL

    Alba, 510053, Romania

  • Canisius-Wilhelmina Ziekenhuis (CWZ)

    Nijmegen, 6532 SZ, Netherlands

  • Cardio Med SRL

    Târgu Mureş, 540124, Romania

  • Cardioplus Center SRL

    Baia Mare, 430123, Romania

  • Centra Medyczne Medyceusz

    Lodz, 91-053, Poland

  • Central Research Associates, Inc.

    Birmingham, Alabama, 35205, United States

  • Centro Hospitalar de Entre Douro e Vouga

    Santa Maria da Feira, 4520-211, Portugal

  • Centro Medico San Luis

    San Luis, D5700, Argentina

  • Centro Médico Dra. Laura Maffei

    Buenos Aires, C1425AGC, Argentina

  • Centro de Investigación Cardiométabolica de Aguascalientes S.A. de C.V.

    Aguascalientes, 20230, Mexico

  • Centrul Medical Medicover Victoria

    Bucharest, 10626, Romania

  • Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed S.R.L

    Brasov, 500283, Romania

  • Centrum Medycnze AMED

    Warsaw, 03-291, Poland

  • Centrum Medyczne Pratia

    Katowice, 40-081, Poland

  • Centrum Zdrowia Metabolicznego

    Poznan, 60-589, Poland

  • Chang Gung Medical Foundation - Linkou Branch

    Taoyuan District, 33305, Taiwan

  • Cientia Investigacion Clinica Sc

    Chihuahua City, 32103, Mexico

  • Clinexpert Kft.

    Budapest, H1033, Hungary

  • Clinic of Cardiology and Rehabilitation

    Klaipėda, LT-91131, Lithuania

  • Clinical Best Solutions

    Lublin, 20-078, Poland

  • Clinical Best Solutions Sp. Z.o.o Spolka Komandytowa

    Warsaw, 00-710, Poland

  • Clinical Investigation Specialists Inc.

    Kenosha, Wisconsin, 53144, United States

  • Clinical Research Institute S.C.

    Tlanepantla, 54055, Mexico

  • Clinical Trial Network

    Houston, Texas, 77074, United States

  • Clinical Trials of America LA, LLC

    Monroe, Louisiana, 71201, United States

  • Clinical Trials of America, LLC

    Lenoir, North Carolina, 28645, United States

  • Clinstile, S.A. de C.V.

    Mexico City, 06700, Mexico

  • Clínica FUSAVIM Privada

    Villa María, X5900JKA, Argentina

  • Columbus Clinical Services

    Miami, Florida, 33125, United States

  • Combined Research Orlando Phase I-IV

    Orlando, Florida, 32807, United States

  • DCC Equita

    Varna, 9000, Bulgaria

  • DCT - McAllen Primary Care, LLC

    McAllen, Texas, 78503, United States

  • DRC Gyogyszervizsgalo Kozpont Kft

    Balatonfüred, H-8230, Hungary

  • Diab sro

    Rožňava, 04801, Slovakia

  • Diabetes & Glandular Disease Clinic, P.A.

    San Antonio, Texas, 78229, United States

  • Diabetes and Endocrinology Consultants, P.C.

    Morehead City, North Carolina, 28557, United States

  • Diabetologická a endokrinologická ambulance Milan Kvapil

    Příbram, 267 01, Czechia

  • ELSAN - Polyclinique Vauban

    Valenciennes, 59300, France

  • ETG Zamosc / Pro Life Medica Sp. z o.o.

    Zamość, 22-400, Poland

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Endokrinologie Cerny Most s.r.o.

    Prague, 198 00, Czechia

  • Eternal Hospital

    Jaipur, 302017, India

  • Etg Lublin

    Lublin, 20-412, Poland

  • FMC Science

    Lampasas, Texas, 76550, United States

  • Fakultni nemocnice v Motole

    Prague, 150 06, Czechia

  • Finlay Medical Research

    Greenacres City, Florida, 33467, United States

  • Fondazione I.R.C.C.S. Policlinico "San Matteo" c/o C.U.R.M.

    Pavia, 27100, Italy

  • Fundacion Favaloro

    Buenos Aires, C1093AAS, Argentina

  • GHM les Portes du Sud

    Vénissieux, 69200, France

  • Gelre Ziekenhuizen Apeldoorn

    Apeldoorn, 7334 DZ, Netherlands

  • Glenny Corp SA

    Buenos Aires, C1430, Argentina

  • Grace Research, LLC

    Bossier City, Louisiana, 71111, United States

  • Harmony Clinical Research, Inc

    North Miami Beach, Florida, 33162, United States

  • Het Van Weel Bethesda ziekenhuis

    Dirksland, 3247BW, Netherlands

  • Hopital de Hautepierre

    Strasbourg, 67098, France

  • Hospital CUF Tejo

    Lisbon, 1350-352, Portugal

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Comarcal Infanta Elena

    Huelva, 21007, Spain

  • Hospital Germans Trias i Pujol

    Badalona, 8916, Spain

  • Hospital Provincial de Conxo

    Santiago de Compostela, 15706, Spain

  • Hospital Regional de Malaga

    Málaga, 29009, Spain

  • Hospital Taiping

    Taiping, Perak, 34000, Malaysia

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital Universitario Walter Cantidio - UFC

    Fortaleza, 60430-270, Brazil

  • Hospital Universitario de Jaen

    Jaén, 23007, Spain

  • Hospital Vall d'Hebron

    Barcelona, 8035, Spain

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - FMUSP

    São Paulo, 05403-900, Brazil

  • Hygeia Hospital

    Athens, 15123, Greece

  • Hôpital Erasme

    Brussels, 1070, Belgium

  • IBPClin Pesquisa Clinica

    Rio de Janeiro, 20241-180, Brazil

  • IPGMER

    Kolkata, 700020, India

  • Instituto Médico DAMIC

    Córdoba, X5003DCE, Argentina

  • Instituto de Cardiología Corrientes

    Corrientes, W3400CDS, Argentina

  • Instituto do Coração - HCFMUSP

    São Paulo, 05403-000, Brazil

  • Interna SK, s.r.o.

    Svidník, 08901, Slovakia

  • Interna a diabetologicka ambulancia - IN-DIA s.r.o.

    Lučenec, 98401, Slovakia

  • JSV Clinical Research Study, Inc.

    Tampa, Florida, 33634, United States

  • Joanne F. Liutkus Medicine Professional Corporation

    Cambridge, Ontario, N3H 4L5, Canada

  • Juno Research

    Houston, Texas, 77040, United States

  • Juno Research

    Houston, Texas, 77054, United States

  • KEM Hospital

    Mumbai, 4000012, India

  • Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH)

    Kaohsiung City, 80756, Taiwan

  • KardioBusak s.r.o.

    Louny, 440 01, Czechia

  • Klinikiniai sprendimai

    Kaunas, LT-49387, Lithuania

  • Lausmed Kft.

    Baja, H-6500, Hungary

  • Louisville Metabolic and Atherosclerosis Research Center (L-MARC)

    Louisville, Kentucky, 40213, United States

  • MHAT Haskovo AD

    Haskovo, 6304, Bulgaria

  • MHAT Pazardzhik AD

    Pazardzhik, 4400, Bulgaria

  • MHAT Sliven to MMA Sofia

    Sliven, 8800, Bulgaria

  • Mackay Memorial Hospital

    New Taipei City, 251404, Taiwan

  • Main Street Physicians Care Waterway

    Little River, South Carolina, 29566, United States

  • Manipal Hospital Mysore

    Mysore, 570015, India

  • Maryland Cardiovascular Specialists

    Baltimore, Maryland, 21229, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Max Super Specialty Hospital

    New Delhi, National Capital Territory of Delhi, 110017, India

  • Medical Care and Research S.A de C.V.

    Mérida, Yucatán, 97070, Mexico

  • Medical Center Diamedical EOOD

    Dimitrovgrad, 6400, Bulgaria

  • Medical Center Smolyan Clinical Research OOD

    Smolyan, 4700, Bulgaria

  • Medical Center Zara - Med

    Stara Zagora, 6000, Bulgaria

  • Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD

    Sofia, 1000, Bulgaria

  • Medical Centre "Nevromedics" EOOD

    Veliko Tarnovo, 5006, Bulgaria

  • Medical Centre Synexus Sofia EOOD

    Sofia, 1784, Bulgaria

  • Medical University of South Carolina (MUSC)

    Charleston, South Carolina, 29425, United States

  • Medico Dental Center ISUL Tsaritsa Yoanna EOOD

    Sofia, 1527, Bulgaria

  • Meridien Research

    Maitland, Florida, 32751, United States

  • Metabolic Research Institute

    West Palm Beach, Florida, 33401, United States

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701, United States

  • NL Health Services

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • NRC Research Institute

    Los Angeles, California, 90015, United States

  • NUPEC - Nucleo de Pesquisa Clinica

    Belo Horizonte, 30220-140, Brazil

  • NYU Langone Hospital - Long Island

    Mineola, New York, 11501, United States

  • Narodowy Instytut Kardiologii im. S. Wyszyńskiego - PIB

    Warsaw, 04-628, Poland

  • National Cheng Kung University Hospital

    Tainan, 704017, Taiwan

  • Northeast Georgia Medical Center

    Gainesville, Georgia, 30501, United States

  • Nucleo de Pesquisa em Cirurgia Vascular

    Porto Alegre, 90035-903, Brazil

  • Núcleo de Pesquisa Clínica

    Curitiba, 80730-150, Brazil

  • Obudai Egeszsegugyi Centrum

    Budapest, H-1036, Hungary

  • Ogden Clinic Grandview

    Roy, Utah, 84401, United States

  • Oklahoma Heart Institute

    Tulsa, Oklahoma, 74133, United States

  • OnSite Clinical Solutions, LLC

    Salisbury, North Carolina, 28144, United States

  • Onyx Clinical Research

    Peoria, Arizona, 85381, United States

  • Onyx Clinical Research

    Flint, Michigan, 48532, United States

  • Onyx Clinical Research

    Rochester Hills, Michigan, 48307, United States

  • Orchard Park Family Practice

    Orchard Park, New York, 14127, United States

  • Permian Research Foundation

    Odessa, Texas, 79761, United States

  • Pharma4 Trial Kft.

    Gyöngyös, H-3200, Hungary

  • Pioneer Research Solutions, Inc

    Houston, Texas, 77099, United States

  • Pirmoji viltis

    Šiauliai, LT-76206, Lithuania

  • Pulau Pinang Hospital

    George Town, Pulau Pinang, 10450, Malaysia

  • R & B Medical Center LLC

    Tampa, Florida, 33614, United States

  • Randomize Now

    Newnan, Georgia, 30265, United States

  • Reinier de Graaf Ziekenhuis

    Delft, 2625 AD, Netherlands

  • Republican Panevezys Hospital

    Panevezys, LT-35144, Lithuania

  • S.C. Mediab Srl

    Târgu Mureş, 540142, Romania

  • S.C. SAL MED S.R.L., Cardiologie

    Piteşti, 10437, Romania

  • SMS Clinical Research, LLC

    Mesquite, Texas, 75149, United States

  • SV Research LLC

    Marion, Ohio, 43302, United States

  • Sante Clinical Research, LLC

    Kerrville, Texas, 78028, United States

  • Saules seimons medicinos centras

    Kaunas, 49449, Lithuania

  • Shin Kong Wu Ho-Su Memorial Hospital

    Taipei, 111045, Taiwan

  • Sir Ganga Ram Hospital

    Delhi, 110060, India

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz Diabetologiai szakrendeles

    Kaposvár, H-7400, Hungary

  • Southern Endocrinology Associates

    Mesquite, Texas, 75149, United States

  • Specialized Hospital for Active Treatment of Cardiology

    Varna, 9000, Bulgaria

  • Sri Jayadeva Institute of Cardiovascular Sciences and Research

    Bengaluru, 560069, India

  • St. Vincent Medical Group

    Carmel, Indiana, 46290, United States

  • Stern Cardiovascular

    Southaven, Mississippi, 38671, United States

  • Sultanah Bahiyah Hospital

    Alor Star, Kedah, 05460, Malaysia

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Texas Health Family Care

    Fort Worth, Texas, 76107, United States

  • Texas Institute of Cardiology

    McKinney, Texas, 75071, United States

  • The Jackson Clinic

    Jackson, Tennessee, 38305, United States

  • The Ohio State University (OSU)

    Columbus, Ohio, 43203, United States

  • The Research Group of Lexington, LLC

    Lexington, Kentucky, 40503, United States

  • Toronto General Hospital

    Toronto, Ontario, M5G2C4, Canada

  • Tranquil Research

    Webster, Texas, 77598, United States

  • UCK, I Klinika Kardiologii

    Gdansk, 80-214, Poland

  • UMHAT - Kaspela EOOD

    Plovdiv, 4000, Bulgaria

  • UMHAT Kanev AD

    Rousse, 7002, Bulgaria

  • UZ Leuven

    Leuven, 3000, Belgium

  • Unidad de Ensayos Clinicos

    Málaga, 29010, Spain

  • Unite de Recherche Clinique

    Saint-Jérôme, Quebec, J7Z 2V4, Canada

  • University General Hospital ATTIKON

    Athens, 12462, Greece

  • University General Hospital of Alexandroupoli

    Alexandroupoli, 68100, Greece

  • University Malaya Medical Centre (UMMC)

    Kuala Lumpur, 59100, Malaysia

  • University Multiprofile Hospital for Active Treatment Pulmed OOD

    Plovdiv, 4000, Bulgaria

  • University of Florida Jacksonville

    Jacksonville, Florida, 32209, United States

  • University of Kansas Medical Center (KUMC)

    Kansas City, Kansas, 66160, United States

  • University of Louisville

    Louisville, Kentucky, 40202, United States

  • University of Maryland School of Medicine

    Baltimore, Maryland, 21201, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Vilo Research Group

    Houston, Texas, 77017, United States

  • Vinaya Hospital and Research Centre (A Unit of Karnataka Institute of Medical Sciences)

    Mangaluru, 575003, India

  • Virga Jessa Hospital

    Hasselt, 3500, Belgium

  • Vumc Amsterdam Medical Center

    Amsterdam, 1081BT, Netherlands

  • i9 Pesquisas Clínicas/Loema - Instituto de Pesquisas Clínica & Consultores

    São Paulo, 13092-133, Brazil

Conditions

Explore the condition pages connected to this study.