New injection aims to tame dangerous blood fats

NCT ID NCT05079919

Summary

This study tested whether a new injectable drug called olezarsen could lower very high triglyceride levels better than a placebo. It involved 617 adults with severely elevated triglycerides who were already on standard cholesterol medications. Participants received either the drug or a placebo injection for 53 weeks to see if it reduced their triglyceride levels and the risk of related health problems.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O. Policlinico Universitario P. Giaccone

    Palermo, 90127, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Aa Mrc, Llc

    Flint, Michigan, 48504, United States

  • Aalborg University Hospital

    Aalborg, 9000, Denmark

  • Aarhus University Hospital

    Aarhus, 8200, Denmark

  • Academic Medical Center - Department of Vascular Medicine

    Amsterdam, 1105 AZ, Netherlands

  • Accel Research Sites Network

    Birmingham, Alabama, 35216, United States

  • Affinity Health

    Oak Brook, Illinois, 60523, United States

  • Albert Schweitzer ziekenhuis

    Dordrecht, 3318 AT, Netherlands

  • America Clinical Trials

    Tarzana, California, 91356, United States

  • Arc Biosystems

    Vancouver, British Columbia, V6Z 2C7, Canada

  • Auckland City Hospital

    Grafton, Auckland, 1010, New Zealand

  • Aventiv Research

    Columbus, Ohio, 43213, United States

  • Azienda Ospedaliera Universitaria Federico II

    Naples, 80131, Italy

  • BKS Research Kft

    Hatvan, Heves County, 3000, Hungary

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Bayside Clinical Research

    Trinity, Florida, 34655, United States

  • Belinus BT

    Debrecen, 4025, Hungary

  • Bispebjerg Hospital

    Frederiksberg, 2000, Denmark

  • Bnai Zion Medical Center

    Haifa, 3339416, Israel

  • Borbanya Praxis Eü KFT

    Nyíregyháza, 4405, Hungary

  • Bryan Medical Center Clinical Research

    Lincoln, Nebraska, 68506, United States

  • CHU Dijon Bourgogne

    Dijon, 21079, France

  • CHU Montpellier - Hôpital Lapeyronie

    Montpellier, 34295, France

  • CHU Nantes - Hopital Nord Laennec

    Saint-Herblain, 44093, France

  • CRU Hungary Kft

    Borsod, 3860, Hungary

  • Canadian Phase Onward Inc

    Toronto, Ontario, M3J 0K2, Canada

  • Cardio D&R

    Košice, 040 22, Slovakia

  • Centro Hospitalar

    Vila Nova de Gaia, 4434-502, Portugal

  • Centro Hospitalar Universitário de São João Consultas Externas de Endocrinologia K13

    Porto, 4200-319, Portugal

  • Centro Hospitalar do Baixo Vouga Hospital Infante D. Pedro

    Aveiro, 3814-501, Portugal

  • Centro Hospitalar e Universitário de Coimbra, EPE

    Coimbra, 3004-561, Portugal

  • Chatsmed Garden Hospital

    Chatsworth, 4092, South Africa

  • Chattanooga Research & Medicine, PLLC

    Chattanooga, Tennessee, 37404, United States

  • Circuit Clinical

    Niagara Falls, New York, 14304, United States

  • Circuit Clinical (Crystal Run Healthcare)

    Middletown, New York, 10941, United States

  • ClinMedica Research Sp.z o.o.

    Skierniewice, 96-100, Poland

  • Clinica Universidad de Navarra

    Madrid, 28027, Spain

  • Clinical Trials of America, LLC

    Monroe, Louisiana, 71201, United States

  • Clinical Trials of America, LLC

    Mount Airy, North Carolina, 27030, United States

  • Clinique des Maladies Lipidiques de Quebec Inc.

    Québec, Quebec, G1V 4W2, Canada

  • Columbia University

    New York, New York, 10032, United States

  • Cone Medical Center

    Greensboro, North Carolina, 27401, United States

  • Continental Clinical Solutions

    Towson, Maryland, 21204, United States

  • DCC 1 Sliven

    Sliven, 8800, Bulgaria

  • DRC Gyogyszervizsgalo Kozpont Kft

    Veszprém, 8230, Hungary

  • Debreceni Egyetem Klinikai Kozpont Belgyogyaszat A epulet

    Debrecen, 4032, Hungary

  • Diabetes/Lipid Management & Research Center

    Huntington Beach, California, 92648, United States

  • Dr Jan Engelbrecht and Ass. Inc

    Cape Town, Western Cape, 7130, South Africa

  • Dr. Heart Pty Ltd at Cholesterol Care Australia

    Woolloongabba, Queensland, 4102, Australia

  • EDUMED s.r.o.

    Hradec Králové, 500 02, Czechia

  • EDUMED s.r.o.

    Náchod, 547 01, Czechia

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9, Canada

  • Ege University School of Medicine, Department of Cardiology

    Izmir, 35100, Turkey (Türkiye)

  • Erasmus MC

    Rotterdam, 3015 GD, Netherlands

  • Esbjerg Hospital

    Esbjerg, 6700, Denmark

  • Evangelisches Krankenhaus Witten

    Witten, 58455, Germany

  • Excel Medical Clinical Trials, LLC

    Boca Raton, Florida, 33434, United States

  • Fakultni nemocnice Ostrava

    Ostrava, 70852, Czechia

  • Fakultní nemocnice Hradec Králové

    Hradec Králové, 500-05, Czechia

  • Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

    Székesfehérvár, 8000, Hungary

  • Finlay Medical Research

    Miami, Florida, 33126, United States

  • Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore

    Roma, 00168, Italy

  • Futuremeds sp. z o.o

    Wroclaw, 50-088, Poland

  • Gabriela Zhelyazkova

    Sliven, 8800, Bulgaria

  • Godstrup Regional Hospital

    Herning, 7400, Denmark

  • Hacettepe University Medical Faculty

    Ankara, 06230, Turkey (Türkiye)

  • Hadassah Hebrew University Ein Kerm MC

    Jerusalem, 91120, Israel

  • Health Concepts

    Rapid City, South Dakota, 57702, United States

  • Herlev Hospital

    Herlev, 2730, Denmark

  • Hightower Clinical Trial Services

    Oklahoma City, Oklahoma, 73102, United States

  • Hopital Pitie Salpetriere APHP

    Paris, 75013, France

  • Hopital de la Conception

    Marseille, 13005, France

  • Hospital Abente y Lago

    A Coruña, 15001, Spain

  • Hospital Clinic Barcelona

    Barcelona, 8063, Spain

  • Hospital Egas Moniz - Centro Hospitalar de Lisboa Ocidental

    Lisbon, 1349-019, Portugal

  • Hospital Universitari Sant Joan de Reus.

    Tarragona, 43204, Spain

  • Hospital Universitari de Bellvitge

    Barcelona, 8907, Spain

  • Hospital Universitario

    Madrid, 28041, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Virgen del Rocio Edificio Centro de Diagnostico y Tratamiento (CDT)

    Seville, 41013, Spain

  • Hospital de la Santa Creu i de Sant Pau

    Barcelona, 08041, Spain

  • Huddersfield Royal Infirmary

    Lindley, Huddersfield, HD3 3EA, United Kingdom

  • Hudson County Clinical Trials Research Center

    Union City, New Jersey, 07087, United States

  • Hull Royal Infirmary

    Hull, HU3 2JZ, United Kingdom

  • Human-Care s.r.o.

    Košice, 040 01, Slovakia

  • Hôpital Louis Pradel

    Bron, 69677, France

  • IACT Health

    Columbus, Georgia, 31904, United States

  • IMA Clinical Research

    St. Petersburg, Florida, 33709, United States

  • IMA Clinical Research

    St Louis, Missouri, 63117, United States

  • IMA Clinical Research Chicago

    Chicago, Illinois, 60602, United States

  • IPR Hungary Kft.

    Miskolc, H-3530, Hungary

  • IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di SantOrsola

    Bologna, 40138, Italy

  • Iatros International

    Bloemfontein, Free State, 9301, South Africa

  • Innovia Research Center, INC

    Miramar, Florida, 33027, United States

  • Institut d'Investigació i Innovació Parc Taulí (I3PT) Departament Medicina Universitat

    Barcelona, 8208, Spain

  • Institut de recherches cliniques de Montréal (IRCM)

    Montreal, Quebec, H2W 1R7, Canada

  • Instytut Centrum Zdrowia Matki Polki Klinika

    Łódz, 93-338, Poland

  • Interni Ambulance

    Uherské Hradiště, 686 01, Czechia

  • Kansas University Medical Center

    Kansas City, Kansas, 66160, United States

  • Kaplan Medical Center

    Rehovot, 7661041, Israel

  • Kardiologische Praxis in Papenburg

    Papenburg, 26871, Germany

  • Karolinska University Hospital Huddinge

    Stockholm, 14186, Sweden

  • Klinische Forschung Hamburg GmbH

    Hamburg, 20253, Germany

  • Klinische Forschung Hannover-Mitte GmbH

    Hanover, 30159, Germany

  • Kocaeli University Faculty of Medicine

    Kocaeli, 41380, Turkey (Türkiye)

  • LA Universal Research Center, Inc.

    Los Angeles, California, 90057, United States

  • Lady Davis Carmel Medical Center

    Haifa, 3436212, Israel

  • Lakeside Healthcare at Corby

    Corby, Northamptonshire, NN172UR, United Kingdom

  • Lekarna Poliklinika Hurka

    Prague, 15800, Czechia

  • Lipid Clinic

    Oslo, 0586, Norway

  • MC Doctor Kalchev OOD

    Sofia, 1700, Bulgaria

  • MEDICUS SERVICES s.r.o.

    Brandýs nad Labem, 250 01, Czechia

  • MHAT "Dr. Tota Venkova" AD

    Gabrovo, 5300, Bulgaria

  • MHAT Blagoevgrad AD

    Blagoevgrad, 2700, Bulgaria

  • Manassas Clinical Research Center

    Manassas, Virginia, 20110, United States

  • Manchester University NHS Foundation Trust (MFT)

    Manchester, M13 9WL, United Kingdom

  • Mayo Clinic

    Scottsdale, Arizona, 85259, United States

  • Medical Centar "KALIMAT"

    Sofia, 1680, Bulgaria

  • Medical Center "Hera" EOOD

    Montana, 3400, Bulgaria

  • Medical Center Diamedical 2013 OOD

    Dimitrovgrad, 6400, Bulgaria

  • Medical Center Doctor Staykov EOOD

    Burgas, 8008, Bulgaria

  • Medical Center Endomedical EOOD

    Sofia, 1606, Bulgaria

  • Medical Center Rusemed EOOD

    Rousse, 7000, Bulgaria

  • Medical Center Smolyan Clinical Research OOD

    Smolyan, 4700, Bulgaria

  • Medical Centre Nevromedics EOOD

    Veliko Tarnovo, 5006, Bulgaria

  • Medicus Alliance Clinical Research

    Sugar Land, Texas, 77478, United States

  • Medifarma 98 Kft

    Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary

  • Medispektrum s.r.o., diabetologicka a metabolicka ambulancia

    Bratislava, 851 01, Slovakia

  • Modern Medical

    Syosset, New York, 11791, United States

  • Modern Medicine

    Brooklyn, New York, 11235, United States

  • Monash Medical Centre

    Clayton S., Victoria, 3168, Australia

  • Mounts Bay Medical Hub

    Cornwell, TR27 5DT, United Kingdom

  • NYU Langone

    New York, New York, 10016, United States

  • Necmettin Erbakan University Meram Medical Faculty

    Konya, 42280, Turkey (Türkiye)

  • Nemocnica arm. generala L. Svobodu Svidnik,

    Svidník, 089 01, Slovakia

  • Nemocnica s poliklinikou Brezno

    Brezno, 97701, Slovakia

  • New Rehabilitation Center

    Stara Zagora, 6000, Bulgaria

  • New Zealand Clinical Research

    Christchurch, 8011, New Zealand

  • Newquay Health Centre

    Newquay, Cornwall, TR7 1RU, United Kingdom

  • Northwell Health

    Great Neck, New York, 11021, United States

  • Novant Health Cancer Institute Elizabeth Investigational Drug Services

    Charlotte, North Carolina, 28204, United States

  • Oak Tree Surgery and Pensilva Health Centre

    Liskeard, Cornwall, PL14 3XA, United Kingdom

  • Ocala Cardiovascular Research

    Ocala, Florida, 34471, United States

  • Ospdale E. Bassini

    Milan, 20092, Italy

  • Osrodek Badan Klinicznych Metabolica

    Tarnów, 33-100, Poland

  • Palm Research Center, INC.

    Las Vegas, Nevada, 89148, United States

  • Panthera

    Glasgow, G51 4TY, United Kingdom

  • Panthera

    London, EN3 4GS, United Kingdom

  • Panthera

    Preston, PR2 9QB, United Kingdom

  • Panthera Biopartners

    Rochdale, England, OL11 4AU, United Kingdom

  • Panthera Biopartners

    Sheffield, England, S2 5FX, United Kingdom

  • Policlinico Umberto

    Roma, 00161, Italy

  • Praktyka Lekarska Ewa Krzyzagorska

    Poznan, 61-655, Poland

  • Praxis Dr. med. Taggeselle

    Markkleeberg, 04416, Germany

  • Primary Care Sheffield

    Sheffield, S94EU, United Kingdom

  • Rabin Medical Center

    Petah Tikva, 4941492, Israel

  • Radboud UMC

    Nijmegen, 6525 GA, Netherlands

  • Regionshospitalet Viborg

    Viborg, 8800, Denmark

  • Rijnstate Arnhem

    Arnhem, 6815 AD, Netherlands

  • Royal Adelaide Hospital

    Adelaide, 5000, Australia

  • Royal North Shoe Hospital

    Saint Leonards, New South Wales, 2065, Australia

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050, Australia

  • SHAT "Special Medic" Ltd

    Plovdiv, 4000, Bulgaria

  • SOROKA Medical Center

    Beersheba, 8410101, Israel

  • Sahlgrenska, University Hospital

    Gothenburg, Västra Götaland County, 413 45, Sweden

  • Salvia

    Katowice, 40-772, Poland

  • Sandwell General Hospital

    Lyne, West Bromwich, B71 4HJ, United Kingdom

  • Semmelweis Egyetem Kardiológiai Rehabilitacio

    Budapest, H-1085, Hungary

  • Shaare Zedek Medical Center

    Jerusalem, 9103102, Israel

  • Sheba Medical Center

    Tel Litwinsky, 5265601, Israel

  • Sourasky Medical Center

    Tel Aviv, 6423909, Israel

  • Southeast Clinical Research LLC

    Chiefland, Florida, 32626, United States

  • St. Josefskrankenhaus,

    Heidelberg, 69115, Germany

  • Stoffwechselcentrum Charite Campus Virchow

    Berlin, 13353, Germany

  • Summit Research Group, LLC

    Munroe Falls, Ohio, 44262, United States

  • TREAD Research - Department of Cardiology

    Parow, Western Cape, 7500, South Africa

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The Miriam Hospital

    Providence, Rhode Island, 02906, United States

  • Turku University Hospital

    Turku, 20520, Finland

  • UMHAT Prof. Dr. Stoyan Kirkovich AD, Clinic of Cardiology

    Stara Zagora, 6000, Bulgaria

  • UMHAT Sofiamed OOD

    Sofia, 1797, Bulgaria

  • Uniklinik Köln

    Cologne, 50937, Germany

  • Unitas Hospital

    Centurion, Gauteng, 157, South Africa

  • Universitaetsklinikum Carl Gustav Carus an der TU Dresden

    Dresden, 1307, Germany

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX, Netherlands

  • University of California, San Diego (UCSD)

    La Jolla, California, 92037, United States

  • University of Cape town - Lipid Factory

    Cape Town, 7925, South Africa

  • University of Michigan Hospital and Health Systems/ Dept. of Pharmacy-Research Pharmacy

    Ann Arbor, Michigan, 48109, United States

  • University of Texas Southwestern

    Dallas, Texas, 75390, United States

  • Upton Surgery

    Poole, Dorset, BH16 5PW, United Kingdom

  • VICIS Clinical Research

    Tampa, Florida, 33614, United States

  • Velocity Clinical

    West Jordan, Utah, 84088, United States

  • Velocity Clinical Research

    Chula Vista, California, 91911, United States

  • Velocity Clinical Research

    Medford, Oregon, 97504, United States

  • Velocity Clinical Research

    Cedar Park, Texas, 78613, United States

  • Vseobecna fakultni nemocnice

    Prague, 128 08, Czechia

  • Vychodoslovensky Ustav srdcovych a cievnych chorob a.s.

    Košice, 040 11, Slovakia

  • Wake Forest University Health Sciences

    Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Waterloo Medical Centre

    Blackpool, FY4 3AD, United Kingdom

  • Wellington Regional Hospital

    Newtown, 6021, New Zealand

  • West Broadway Clinic

    Council Bluffs, Iowa, 51501, United States

  • West Virginia University Heart and Vascular Institute

    Morgantown, West Virginia, 26506, United States

  • Westside Center for Clinical Research

    Jacksonville, Florida, 32205, United States

  • Ylitornio Health Care Center

    Ylitornio, 95600, Finland

  • York Clinical Research LLC

    Norfolk, Virginia, 23510, United States

  • Ziekenhuis Gelderse Vallei

    Ede, 6716 RP, Netherlands

  • Észak-Pesti Centrumkórház - Honvédkórház; II. Belgyógyászati Osztály

    Budapest, H-1062, Hungary

Conditions

Explore the condition pages connected to this study.