New drug combo aims to fight Hard-to-Treat sarcomas

NCT ID NCT04668300

First seen Oct 31, 2025 · Last updated May 16, 2026 · Updated 33 times

Summary

This study tests whether two immunotherapy drugs, oleclumab and durvalumab, can help people with sarcoma that has come back, spread, or stopped responding to treatment. About 75 adults and some teens (age 12+) with angiosarcoma, dedifferentiated liposarcoma, or osteosarcoma will receive these drugs to see if they shrink tumors or slow the cancer. The goal is to find a new option for these rare and aggressive cancers.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.