Eye scan math: can two different machines agree on diabetic macular oedema?
NCT ID NCT07816627
First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time
Summary
Researchers are studying how measurements from two different optical coherence tomography (OCT) machines compare when scanning the back of the eye. The trial includes 338 adults with diabetes and diabetic macular oedema. Participants receive OCT scans on both a Heidelberg Spectralis and a Topcon Triton machine. The goal is to calculate a conversion equation so that measurements from one machine can be understood in terms of the other.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Optical coherence tomography scans using two different machines
- What this could lead to
- If it works, doctors could compare eye scans from different OCT machines directly, which may make it easier to track diabetic macular oedema over time.
- What could go wrong
- The study only looks at two specific scanner models, so the equation may not apply to other machines. It also does not test whether using the equation improves patient care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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338 people
The number who actually took part.
- Started
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Mar 2024
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with a diagnosis of Diabetic Macular Oedema (DMO) as recorded on the Ophthalmology Electronic Medical Record system (Medisoft/Medisight) within Gloucestershire Hospitals NHS Foundation Trust.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged 18 years or above * Patients with a diagnosis of Type 1 or Type 2 Diabetes Mellitus * Patients with a known diagnosis of DMO in at least one eye * Patients being seen in DMO clinics, Digital Surveillance Clinic or Virtual Diabetic Retinopathy clinics Exclusion Criteria: * Patients under 18 years old * People unwilling or unable to give informed consent * Patients in whom it is not possible to take OCT scans, for instance those with: * Dense cataracts * Corneal Scarring * Severe physical disabilities preventing them from adequate positioning. * People with other ocular pathologies known to impact retinal thickness, including: * Age related Macular Degeneration (AMD) * Branch or central retinal vein occlusion (BRVO/CRVO) * Macular Hole * Glaucoma * High Myopia with a spherical equivalent \> -5.00 diopters * Epiretinal membrane * Eyes with at least one scan containing segmentation errors * Eyes with at least one scan that is ungradable
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Gloucestershire Hospitals NHS Foundation Trust
Gloucester, Gloucestershire, GL53 7AN, United Kingdom
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