Major trial tests drug to halt worsening disability in progressive MS
NCT ID NCT04035005
Summary
This large, late-stage study is testing whether the drug ocrelizumab (Ocrevus®) can slow down the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). Over 1,000 participants were randomly assigned to receive either the drug or a placebo (inactive substance) via an IV infusion every 6 months for at least 3 years. The main goal is to see if the drug can delay the time it takes for a person's walking or hand function to get noticeably worse and confirmed over 12 weeks.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AOU dell Universita degli Studi della Campania Luigi Vanvitelli Piazza Luigi Miraglia 2
Naples, Campania, 80138, Italy
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Albert Einstein Medical Center
Philadelphia, Pennsylvania, 19141, United States
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Austin Hospital
Heidelberg, Victoria, 3084, Australia
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Azienda Ospedaliera Sant'andrea
Rome, Lazio, 00189, Italy
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Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, 10043, Italy
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Belyayev Clinical Hospital of the Kuzbass
Kemerovo, 650066, Russia
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Brain and Mind Research Institute
Camperdown, New South Wales, 2050, Australia
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CHRU Nancy
Nancy, 54035, France
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CHU Mohammed VI
Marrakesh, 40080, Morocco
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CHU de Bordeaux - Hôpital Pellegrin
Bordeaux, 33076, France
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CHU de Nimes - Hopital Universitaire Caremeau
Nîmes, 30900, France
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Cai Ferate Clinical Hospital
Constanța, 900123, Romania
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Campus Neurologico Senior
Torres Vedras, 2560-280, Portugal
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Centre Hospitalier Ibn Sina CHIS - Hopital des Specialites
Rabat, 10100, Morocco
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Centre Hospitalier Universitaire de Clermont Ferrand
Clermont-Ferrand, 63003, France
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Centrum Medyczne Medyk
Rzeszów, Podkarpackie Voivodeship, 35-055, Poland
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Centrum Medyczne NeuroProtect Zablocinska 10
Warsaw, 01-684, Poland
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Centrum Neurologii Krzysztof Selmaj
Lodz, 90-324, Poland
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City Clinical Hospital #24
Moscow, Moscow Oblast, 127015, Russia
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City Clinical Hospital #4
Saransk, Saratov Oblast, 430032, Russia
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City Clinical Hospital a n Buyanov V M
Moscow, Moscow Oblast, 115516, Russia
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City Hospital #40 of Kurortniy Administrative District
Saint Petersburg, Sankt-Peterburg, 197706, Russia
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Clinica Colsanitas S.A. sede Clinica Universitaria Colombia
Bogotá, 111321, Colombia
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Clinical Center Nis
Niš, 18000, Serbia
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Clinical Centre of Vojvodina
Nova Sad, 21000, Serbia
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Clinical Hospital Centre Zemun
Belgrade, 11080, Serbia
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Clinical Hospital Sestre Milosrdnice
Zagreb, 10000, Croatia
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Clinical Research Institute
Tlalnepantla, 54055, Mexico
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Cliniques Universitaires St-Luc
Brussels, 1200, Belgium
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Columbus Neuroscience
Westerville, Ohio, 43082-6910, United States
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Communal Non-Commercial Enterprise Clinical Hospital #15 of the Podilskyi District ofthe Kyiv City
Kyiv, KIEV Governorate, 04070, Ukraine
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Communal Non-commercial Enterprise of Kharkiv Regional Council Regional Clinical Hospital
Kharkiv, 61022, Ukraine
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Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital
Lviv, Kharkiv Governorate, 79010, Ukraine
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Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital
Lviv, Lviv Oblast, 79010, Ukraine
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Complejo Asistencial Universitario de Salamanca ? H. Clinico
Salamanca, 37007, Spain
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Complejo Hospitalario Universitario de Vigo
Vigo, Pontevedra, 36312, Spain
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Copernicus Podmiot Leczniczy Sp z o o
Gda?sk, 80-803, Poland
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Dalhousie Multiple Sclerosis Research Unit
Halifax, Nova Scotia, B3H 4K4, Canada
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Dunedin Hospital
Dunedin, New Zealand
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EUROMEDIS Sp z o o
Szczecin, 70-215, Poland
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FSBIH Siberian Regional Medical Centre of FMBA of Russia
Novosibirsk, 630007, Russia
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Fattouma Bourguiba University Hospital
Monastir, 5000, Tunisia
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Fondazione Istituto G. Giglio di Cefalu
Cefalù, Sicily, 90015, Italy
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Fondazione Istituto Neurologico Mondino IRCCS
Pavia, Lombardy, 27100, Italy
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Fondazione PTV Policlinico Tor Vergata
Rome, Lazio, 00133, Italy
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Galen Clinic
Lublin, 20-064, Poland
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General Hospital Uzice
Užice, 31000, Serbia
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General Hospital Varazdin
Varaždin, 42000, Croatia
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Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
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Grupo Medico Camino
Mexico City, Mexico CITY (federal District), 03310, Mexico
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Hopital Civil
Strasbourg, 67098, France
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Hopital Guillaume Et Rene Laennec
Nantes, 44805, France
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Hopital Razi
LA Mannouba, 2010, Tunisia
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Hospital Angeles Chihuahua
Chihuahua City, 31238, Mexico
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Garcia de Orta
Almada, 2805-267, Portugal
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Hospital Habib Bourguiba
Sfax, 3029, Tunisia
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
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Hospital Universitario Puerta de Hierro - Majadahonda
Madrid, 28222, Spain
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Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Hospital Universitario Virgen de La Arrixaca
El Palmar, Murcia, 30120, Spain
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Hospital de Braga
Braga, 4710-243, Portugal
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Hospital de Santo Antonio
Porto, 4099-001, Portugal
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Hotel Dieu de France
Achrafieh Beirut, 000000, Lebanon
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IRCCS AOM Azienda Ospedaliera Metropolitana
Genoa, Liguria, 16132, Italy
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Instituto Neurologico de Colombia INDEC
Medellín, Antioquia, 50012, Colombia
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Khechinashvili University Hospital
Tbilisi, 179, Georgia
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Kirov State Medical Academy
Kirov, 610027, Russia
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Krasnoyarsk State Medical Academy
Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia
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Kyiv City Clinical Hospital #4
Kyiv, KIEV Governorate, 03110, Ukraine
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LLC Medical Center Family Medicine Clinic
Dnipro, 49600, Ukraine
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LLC Medical Center Health Clinic
Vinnytsia, Volhynian Governorate, 21009, Ukraine
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LLC Medical Center INET 09
Zaporizhzhia, 69035, Ukraine
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LLC Medical Center Unimed
Zaporizhzhia, Zaporizhzhia Oblast, 69000, Ukraine
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MA-LEK Clinical Sp. Z o.o.
Katowice, 40-571, Poland
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MEDIS Limited Liability Company
Nizhny Novgorod, Niznij Novgorod, 603137, Russia
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MS & Neurologisch Revalidatie Centrum
Overpelt, 3900, Belgium
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MS and Neuromuscular Center of Excellence
Clearwater, Florida, 33761, United States
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Mazowieckie Centrum Badan Klinicznych
Grodzisk Mazowiecki, 05-825, Poland
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Med-Polonia Sp. z o.o.
Poznan, 60-693, Poland
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Medical Center Artes Medicum LLC
Kyiv, Kyiv Oblast, 02002, Ukraine
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Medical Center Salutem
Vinnytsia, Podolia Governorate, 21009, Ukraine
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Medical Center of LLC Medical Center Dopomoga Plus
Kyiv, 02000, Ukraine
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Medical Centre of PE First Private Clinic
Kyiv, KIEV Governorate, 03037, Ukraine
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Military Hospital of Tunis
Tunis, 1008, Tunisia
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Military Medical Academy
Belgrade, 11000, Serbia
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Military Medical Academy HBAT
Pleven, 5800, Bulgaria
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Morriston Hospital
Swansea, SA6 6NL, United Kingdom
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Moscow Regional Research Clinical Institute Na Mfvladimirskiy
Moscow, Moscow Oblast, 129110, Russia
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Multiprofile Hospital For Active Treatment Avis Medica
Pleven, 5800, Bulgaria
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Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv. Naum EAD
Sofia, 1113, Bulgaria
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Municipal NPE Regional Clinical Center of Neurosurgery and Neurology of Transcarpathian RC
Uzhhorod, KIEV Governorate, 88018, Ukraine
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Municipal Non-profit Enterprise Kherson City Clinical Hospital named after Ye.Ye. Karabelesh
Kherson, Kherson Governorate, 73000, Ukraine
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Municipal Non-profit Enterprise Zaporizhzhya Regional Hospital Zaporizhzhya Regional Council
Zaporizhzhia, 69600, Ukraine
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NEURO-MEDIC Sp. z o. o.
Katowice, 40-686, Poland
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National Center of Socially Significant Diseases
Saint Petersburg, Sankt-Peterburg, 197110, Russia
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Neftyanik Medical and Sanitary Unit
Tumen, Moscow Oblast, 625000, Russia
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Neurocentrum Bydgoszcz sp z o.o
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
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Neurociencias Estudios Clinicos S.C.
Culiacán, Sinaloa, 80020, Mexico
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Neurological Services of Orlando
Orlando, Florida, 32806, United States
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New Zealand Clinical Research - Christchurch
Christchurch, 8011, New Zealand
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Nizhegorodskaya Regional Clinical Hospital n.a. Semashko
Nizhny Novgorod, Niznij Novgorod, 603126, Russia
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Novo-Med Zielinski i wsp SpJ
Katowice, 40-584, Poland
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Ospedale San Raffaele S.r.l. - PPDS
Milan, Lombardy, 20132, Italy
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Peninsula College of Medicine and Dentistry
Plymouth, PL6 8BX, United Kingdom
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Perm Regional Clinical Hospital of Znak Pocheta Medal
Perm, 614990, Russia
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Pineo Medical Ecosystem LTD
Tbilisi, 0114, Georgia
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Private Enterprise Clinic Medicom
Kyiv, 04219, Ukraine
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Przychodnia EuroMediCare
Wroclaw, Lower Silesian Voivodeship, 50-220, Poland
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Queen Elizabeth University Hospital - PPDS
Glasgow, G51 4TF, United Kingdom
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RESMEDICA Spolka z o.o.
Kielce, Świętokrzyskie Voivodeship, 25-726, Poland
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Raigmore Hospital - PPDS
Inverness, IV2 3JH, United Kingdom
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Recherche Sepmus Inc.
Greenfield Park, Quebec, J4V 2J2, Canada
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Rejdak Konrad Indywidualna Praktyka Lekarska dr hab. Konrad Rejdak
Lublin, Lublin Voivodeship, 20-410, Poland
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Research Center of Neurology of RAMS
Moskva, Moscow Oblast, 125367, Russia
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Royal Hallamshire Hospital
Sheffield, S10 2JF, United Kingdom
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Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
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SBHI of Nizhny Novgorod region City Clinical Hospital #3
Nizhny Novgorod, Niznij Novgorod, 603155, Russia
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SC Clubul Sanatatii SRL
Campulung Muscel, 115100, Romania
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SPZOZ Wojewodzki Szpital Specjalistyczny nr 3
Rybnik, Silesian Voivodeship, 44-200, Poland
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Saint George University Medical Hospital
El Achrafiyé, DUMMY_VALUE, Lebanon
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Salford Royal Hospital
Salford, M6 8HD, United Kingdom
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Siberian State Medical University of Roszdrav
Tomsk, 634050, Russia
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Specjalistyczna Praktyka Lekarska Dr n.med. Stanislaw Ochudlo
Katowice, 40-752, Poland
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Spitalul Judetean de Urgenta Deva
Deva, Hunedoara County, 330084, Romania
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St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
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Sverdlovsk Regional Clinical Hospital 1
Yekaterinburg, Sverdlovsk Oblast, 620102, Russia
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Szpital Uniwersytecki w Krakowie
Krakow, 31-503, Poland
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Targu Mures Clinical Emergency County Hospital
Târgu Mure?, 540136, Romania
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The Boster Center for Multiple Sclerosis a Singlepoint Healthcare Company
Columbus, Ohio, 43235-5422, United States
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The First University Clinic of Tbilisi State Medical University
Tbilisi, 0141, Georgia
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The National Hospital for Neurology & Neurosurgery
London, GT LON, WC1N 3BG, United Kingdom
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The Royal London Hospital
London, E1 1BB, United Kingdom
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Treatment and Diagnostic Center of LLC MRT Elit
Kropyvnytskyi, KIEV Governorate, 25005, Ukraine
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Treatment and diagnostic Center Neuro Global of LLC Neuro Global
Krykhivtsi, Ivano-Frankivsk Oblast, 76493, Ukraine
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ULS de Loures-Odivelas, EPE - Hospital de Loures
Loures, Lisbon District, 2674-514, Portugal
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UZ Antwerpen
Edegem, Antwerpen, 2650, Belgium
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Ulyanovsk Regional Clinical Hospital
Ulyanovsk, Ulyanovsk Oblast, 432063, Russia
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Unidad de Investigacion en Salud de Chihuahua
Mexico City, 14050, Mexico
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University Clinical Center Kragujevac
Kragujevac, 34000, Serbia
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University Clinical Center of Serbia -PPDS
Belgrade, 11000, Serbia
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University Hospital Center Zagreb
Zagreb, 10000, Croatia
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University Hospital of Wales
Cardiff, CF14 4XW, United Kingdom
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University hospital of Dnipro State Medical University
Dnipro, 49089, Ukraine
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University of Alberta
Edmonton, Alberta, T6G 2G3, Canada
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Nottingham
Nottingham, NG7 2UH, United Kingdom
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Uniwersytecki Szpital Kliniczny w Bialymstoku Marii Sklodowskiej Curie 24a
Bia?ystok, 15-276, Poland
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Vero Neurology
Vero Beach, Florida, 32960, United States
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Vertebronevrologiya LLC
Kazan', Tatarstan Republic, 420043, Russia
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Volyn Regional Clinical Hospital
Lutsk, 43005, Ukraine
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Wojewodzki Szpital Specjalistyczny
Olsztyn, 10-561, Poland
Conditions
Explore the condition pages connected to this study.