Major trial tests drug to halt worsening disability in progressive MS

NCT ID NCT04035005

Summary

This large, late-stage study is testing whether the drug ocrelizumab (Ocrevus®) can slow down the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). Over 1,000 participants were randomly assigned to receive either the drug or a placebo (inactive substance) via an IV infusion every 6 months for at least 3 years. The main goal is to see if the drug can delay the time it takes for a person's walking or hand function to get noticeably worse and confirmed over 12 weeks.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AOU dell Universita degli Studi della Campania Luigi Vanvitelli Piazza Luigi Miraglia 2

    Naples, Campania, 80138, Italy

  • Albert Einstein Medical Center

    Philadelphia, Pennsylvania, 19141, United States

  • Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Azienda Ospedaliera Sant'andrea

    Rome, Lazio, 00189, Italy

  • Azienda Ospedaliero-Universitaria San Luigi Gonzaga

    Orbassano, Piedmont, 10043, Italy

  • Belyayev Clinical Hospital of the Kuzbass

    Kemerovo, 650066, Russia

  • Brain and Mind Research Institute

    Camperdown, New South Wales, 2050, Australia

  • CHRU Nancy

    Nancy, 54035, France

  • CHU Mohammed VI

    Marrakesh, 40080, Morocco

  • CHU de Bordeaux - Hôpital Pellegrin

    Bordeaux, 33076, France

  • CHU de Nimes - Hopital Universitaire Caremeau

    Nîmes, 30900, France

  • Cai Ferate Clinical Hospital

    Constanța, 900123, Romania

  • Campus Neurologico Senior

    Torres Vedras, 2560-280, Portugal

  • Centre Hospitalier Ibn Sina CHIS - Hopital des Specialites

    Rabat, 10100, Morocco

  • Centre Hospitalier Universitaire de Clermont Ferrand

    Clermont-Ferrand, 63003, France

  • Centrum Medyczne Medyk

    Rzeszów, Podkarpackie Voivodeship, 35-055, Poland

  • Centrum Medyczne NeuroProtect Zablocinska 10

    Warsaw, 01-684, Poland

  • Centrum Neurologii Krzysztof Selmaj

    Lodz, 90-324, Poland

  • City Clinical Hospital #24

    Moscow, Moscow Oblast, 127015, Russia

  • City Clinical Hospital #4

    Saransk, Saratov Oblast, 430032, Russia

  • City Clinical Hospital a n Buyanov V M

    Moscow, Moscow Oblast, 115516, Russia

  • City Hospital #40 of Kurortniy Administrative District

    Saint Petersburg, Sankt-Peterburg, 197706, Russia

  • Clinica Colsanitas S.A. sede Clinica Universitaria Colombia

    Bogotá, 111321, Colombia

  • Clinical Center Nis

    Niš, 18000, Serbia

  • Clinical Centre of Vojvodina

    Nova Sad, 21000, Serbia

  • Clinical Hospital Centre Zemun

    Belgrade, 11080, Serbia

  • Clinical Hospital Sestre Milosrdnice

    Zagreb, 10000, Croatia

  • Clinical Research Institute

    Tlalnepantla, 54055, Mexico

  • Cliniques Universitaires St-Luc

    Brussels, 1200, Belgium

  • Columbus Neuroscience

    Westerville, Ohio, 43082-6910, United States

  • Communal Non-Commercial Enterprise Clinical Hospital #15 of the Podilskyi District ofthe Kyiv City

    Kyiv, KIEV Governorate, 04070, Ukraine

  • Communal Non-commercial Enterprise of Kharkiv Regional Council Regional Clinical Hospital

    Kharkiv, 61022, Ukraine

  • Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital

    Lviv, Kharkiv Governorate, 79010, Ukraine

  • Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital

    Lviv, Lviv Oblast, 79010, Ukraine

  • Complejo Asistencial Universitario de Salamanca ? H. Clinico

    Salamanca, 37007, Spain

  • Complejo Hospitalario Universitario de Vigo

    Vigo, Pontevedra, 36312, Spain

  • Copernicus Podmiot Leczniczy Sp z o o

    Gda?sk, 80-803, Poland

  • Dalhousie Multiple Sclerosis Research Unit

    Halifax, Nova Scotia, B3H 4K4, Canada

  • Dunedin Hospital

    Dunedin, New Zealand

  • EUROMEDIS Sp z o o

    Szczecin, 70-215, Poland

  • FSBIH Siberian Regional Medical Centre of FMBA of Russia

    Novosibirsk, 630007, Russia

  • Fattouma Bourguiba University Hospital

    Monastir, 5000, Tunisia

  • Fondazione Istituto G. Giglio di Cefalu

    Cefalù, Sicily, 90015, Italy

  • Fondazione Istituto Neurologico Mondino IRCCS

    Pavia, Lombardy, 27100, Italy

  • Fondazione PTV Policlinico Tor Vergata

    Rome, Lazio, 00133, Italy

  • Galen Clinic

    Lublin, 20-064, Poland

  • General Hospital Uzice

    Užice, 31000, Serbia

  • General Hospital Varazdin

    Varaždin, 42000, Croatia

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • Grupo Medico Camino

    Mexico City, Mexico CITY (federal District), 03310, Mexico

  • Hopital Civil

    Strasbourg, 67098, France

  • Hopital Guillaume Et Rene Laennec

    Nantes, 44805, France

  • Hopital Razi

    LA Mannouba, 2010, Tunisia

  • Hospital Angeles Chihuahua

    Chihuahua City, 31238, Mexico

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Garcia de Orta

    Almada, 2805-267, Portugal

  • Hospital Habib Bourguiba

    Sfax, 3029, Tunisia

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario Puerta de Hierro - Majadahonda

    Madrid, 28222, Spain

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital Universitario Virgen de La Arrixaca

    El Palmar, Murcia, 30120, Spain

  • Hospital de Braga

    Braga, 4710-243, Portugal

  • Hospital de Santo Antonio

    Porto, 4099-001, Portugal

  • Hotel Dieu de France

    Achrafieh Beirut, 000000, Lebanon

  • IRCCS AOM Azienda Ospedaliera Metropolitana

    Genoa, Liguria, 16132, Italy

  • Instituto Neurologico de Colombia INDEC

    Medellín, Antioquia, 50012, Colombia

  • Khechinashvili University Hospital

    Tbilisi, 179, Georgia

  • Kirov State Medical Academy

    Kirov, 610027, Russia

  • Krasnoyarsk State Medical Academy

    Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia

  • Kyiv City Clinical Hospital #4

    Kyiv, KIEV Governorate, 03110, Ukraine

  • LLC Medical Center Family Medicine Clinic

    Dnipro, 49600, Ukraine

  • LLC Medical Center Health Clinic

    Vinnytsia, Volhynian Governorate, 21009, Ukraine

  • LLC Medical Center INET 09

    Zaporizhzhia, 69035, Ukraine

  • LLC Medical Center Unimed

    Zaporizhzhia, Zaporizhzhia Oblast, 69000, Ukraine

  • MA-LEK Clinical Sp. Z o.o.

    Katowice, 40-571, Poland

  • MEDIS Limited Liability Company

    Nizhny Novgorod, Niznij Novgorod, 603137, Russia

  • MS & Neurologisch Revalidatie Centrum

    Overpelt, 3900, Belgium

  • MS and Neuromuscular Center of Excellence

    Clearwater, Florida, 33761, United States

  • Mazowieckie Centrum Badan Klinicznych

    Grodzisk Mazowiecki, 05-825, Poland

  • Med-Polonia Sp. z o.o.

    Poznan, 60-693, Poland

  • Medical Center Artes Medicum LLC

    Kyiv, Kyiv Oblast, 02002, Ukraine

  • Medical Center Salutem

    Vinnytsia, Podolia Governorate, 21009, Ukraine

  • Medical Center of LLC Medical Center Dopomoga Plus

    Kyiv, 02000, Ukraine

  • Medical Centre of PE First Private Clinic

    Kyiv, KIEV Governorate, 03037, Ukraine

  • Military Hospital of Tunis

    Tunis, 1008, Tunisia

  • Military Medical Academy

    Belgrade, 11000, Serbia

  • Military Medical Academy HBAT

    Pleven, 5800, Bulgaria

  • Morriston Hospital

    Swansea, SA6 6NL, United Kingdom

  • Moscow Regional Research Clinical Institute Na Mfvladimirskiy

    Moscow, Moscow Oblast, 129110, Russia

  • Multiprofile Hospital For Active Treatment Avis Medica

    Pleven, 5800, Bulgaria

  • Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv. Naum EAD

    Sofia, 1113, Bulgaria

  • Municipal NPE Regional Clinical Center of Neurosurgery and Neurology of Transcarpathian RC

    Uzhhorod, KIEV Governorate, 88018, Ukraine

  • Municipal Non-profit Enterprise Kherson City Clinical Hospital named after Ye.Ye. Karabelesh

    Kherson, Kherson Governorate, 73000, Ukraine

  • Municipal Non-profit Enterprise Zaporizhzhya Regional Hospital Zaporizhzhya Regional Council

    Zaporizhzhia, 69600, Ukraine

  • NEURO-MEDIC Sp. z o. o.

    Katowice, 40-686, Poland

  • National Center of Socially Significant Diseases

    Saint Petersburg, Sankt-Peterburg, 197110, Russia

  • Neftyanik Medical and Sanitary Unit

    Tumen, Moscow Oblast, 625000, Russia

  • Neurocentrum Bydgoszcz sp z o.o

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland

  • Neurociencias Estudios Clinicos S.C.

    Culiacán, Sinaloa, 80020, Mexico

  • Neurological Services of Orlando

    Orlando, Florida, 32806, United States

  • New Zealand Clinical Research - Christchurch

    Christchurch, 8011, New Zealand

  • Nizhegorodskaya Regional Clinical Hospital n.a. Semashko

    Nizhny Novgorod, Niznij Novgorod, 603126, Russia

  • Novo-Med Zielinski i wsp SpJ

    Katowice, 40-584, Poland

  • Ospedale San Raffaele S.r.l. - PPDS

    Milan, Lombardy, 20132, Italy

  • Peninsula College of Medicine and Dentistry

    Plymouth, PL6 8BX, United Kingdom

  • Perm Regional Clinical Hospital of Znak Pocheta Medal

    Perm, 614990, Russia

  • Pineo Medical Ecosystem LTD

    Tbilisi, 0114, Georgia

  • Private Enterprise Clinic Medicom

    Kyiv, 04219, Ukraine

  • Przychodnia EuroMediCare

    Wroclaw, Lower Silesian Voivodeship, 50-220, Poland

  • Queen Elizabeth University Hospital - PPDS

    Glasgow, G51 4TF, United Kingdom

  • RESMEDICA Spolka z o.o.

    Kielce, Świętokrzyskie Voivodeship, 25-726, Poland

  • Raigmore Hospital - PPDS

    Inverness, IV2 3JH, United Kingdom

  • Recherche Sepmus Inc.

    Greenfield Park, Quebec, J4V 2J2, Canada

  • Rejdak Konrad Indywidualna Praktyka Lekarska dr hab. Konrad Rejdak

    Lublin, Lublin Voivodeship, 20-410, Poland

  • Research Center of Neurology of RAMS

    Moskva, Moscow Oblast, 125367, Russia

  • Royal Hallamshire Hospital

    Sheffield, S10 2JF, United Kingdom

  • Royal Melbourne Hospital

    Parkville, Victoria, 3050, Australia

  • SBHI of Nizhny Novgorod region City Clinical Hospital #3

    Nizhny Novgorod, Niznij Novgorod, 603155, Russia

  • SC Clubul Sanatatii SRL

    Campulung Muscel, 115100, Romania

  • SPZOZ Wojewodzki Szpital Specjalistyczny nr 3

    Rybnik, Silesian Voivodeship, 44-200, Poland

  • Saint George University Medical Hospital

    El Achrafiyé, DUMMY_VALUE, Lebanon

  • Salford Royal Hospital

    Salford, M6 8HD, United Kingdom

  • Siberian State Medical University of Roszdrav

    Tomsk, 634050, Russia

  • Specjalistyczna Praktyka Lekarska Dr n.med. Stanislaw Ochudlo

    Katowice, 40-752, Poland

  • Spitalul Judetean de Urgenta Deva

    Deva, Hunedoara County, 330084, Romania

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1W8, Canada

  • Sverdlovsk Regional Clinical Hospital 1

    Yekaterinburg, Sverdlovsk Oblast, 620102, Russia

  • Szpital Uniwersytecki w Krakowie

    Krakow, 31-503, Poland

  • Targu Mures Clinical Emergency County Hospital

    Târgu Mure?, 540136, Romania

  • The Boster Center for Multiple Sclerosis a Singlepoint Healthcare Company

    Columbus, Ohio, 43235-5422, United States

  • The First University Clinic of Tbilisi State Medical University

    Tbilisi, 0141, Georgia

  • The National Hospital for Neurology & Neurosurgery

    London, GT LON, WC1N 3BG, United Kingdom

  • The Royal London Hospital

    London, E1 1BB, United Kingdom

  • Treatment and Diagnostic Center of LLC MRT Elit

    Kropyvnytskyi, KIEV Governorate, 25005, Ukraine

  • Treatment and diagnostic Center Neuro Global of LLC Neuro Global

    Krykhivtsi, Ivano-Frankivsk Oblast, 76493, Ukraine

  • ULS de Loures-Odivelas, EPE - Hospital de Loures

    Loures, Lisbon District, 2674-514, Portugal

  • UZ Antwerpen

    Edegem, Antwerpen, 2650, Belgium

  • Ulyanovsk Regional Clinical Hospital

    Ulyanovsk, Ulyanovsk Oblast, 432063, Russia

  • Unidad de Investigacion en Salud de Chihuahua

    Mexico City, 14050, Mexico

  • University Clinical Center Kragujevac

    Kragujevac, 34000, Serbia

  • University Clinical Center of Serbia -PPDS

    Belgrade, 11000, Serbia

  • University Hospital Center Zagreb

    Zagreb, 10000, Croatia

  • University Hospital of Wales

    Cardiff, CF14 4XW, United Kingdom

  • University hospital of Dnipro State Medical University

    Dnipro, 49089, Ukraine

  • University of Alberta

    Edmonton, Alberta, T6G 2G3, Canada

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Nottingham

    Nottingham, NG7 2UH, United Kingdom

  • Uniwersytecki Szpital Kliniczny w Bialymstoku Marii Sklodowskiej Curie 24a

    Bia?ystok, 15-276, Poland

  • Vero Neurology

    Vero Beach, Florida, 32960, United States

  • Vertebronevrologiya LLC

    Kazan', Tatarstan Republic, 420043, Russia

  • Volyn Regional Clinical Hospital

    Lutsk, 43005, Ukraine

  • Wojewodzki Szpital Specjalistyczny

    Olsztyn, 10-561, Poland

Conditions

Explore the condition pages connected to this study.