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New cocktail aims to wipe out mantle cell lymphoma in two years

NCT ID NCT04802590

Ongoing Disease control Sponsor: The Lymphoma Academic Research Organisation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding venetoclax to ibrutinib and an anti-CD20 antibody can better clear minimal residual disease in people with newly diagnosed mantle cell lymphoma. About 210 patients will receive either the two-drug or three-drug combo for up to two years, plus antibody therapy for 3.5 years. The main goal is to see how many patients have no detectable cancer cells after six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Ibrutinib, venetoclax, and anti-CD20 antibody
What this could lead to
If successful, this could lead to a more effective fixed-duration treatment for newly diagnosed mantle cell lymphoma, potentially reducing the need for continuous therapy.
What could go wrong
This is a phase 2 trial with 210 participants, so results are still preliminary. The combination may cause side effects like low blood counts, infections, or heart issues, and it's not yet clear if it will improve long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mantle cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MANTLE CELL LYMPHOMA

Contacts and locations

Locations

  • A.Z. Sint Jan AV

    Bruges, 8000, Belgium

  • CH Henri Mondor

    Créteil, 94010, France

  • CH d'Avignon - Hopital Henri Duffaut

    Avignon, 84000, France

  • CH de Bretagne Atlantique - Hopital CHUBERT

    Vannes, 56017, France

  • CH de Cornouaille

    Quimper, 29107, France

  • CH de la Côte Basque

    Bayonne, 64109, France

  • CHD de Vendée

    La Roche-sur-Yon, 85925, France

  • CHRU de Lille

    Lille, 59037, France

  • CHU Bretonneau

    Tours, 37044, France

  • CHU Jean Minioz

    Besançon, 25030, France

  • CHU Nancy Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHU Pontchaillou

    Rennes, 35033, France

  • CHU d'Angers

    Angers, 49033, France

  • CHU de DIJON

    Dijon, 21000, France

  • CHU de Grenoble

    La Tronche, 38700, France

  • CHU de Liege

    Liège, 4000, Belgium

  • CHU de Montpellier

    Montpellier, 34295, France

  • CHU de Nantes

    Nantes, 44093, France

  • CHU de REIMS

    Reims, 51092, France

  • Centre Henri BECQUEREL

    Rouen, 76038, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • Centre Léon Bérard

    Lyon, 69373, France

  • Ch Annecy Gennevois

    Pringy, 74374, France

  • Chu Estaing

    Clermont-Ferrand, 63003, France

  • Chu de Bordeaux - Hopital Haut-Leveque - Centre Francois Magendie

    Pessac, 33604, France

  • Chu de Brest - Hopital de La Cavale Blanche

    Brest, 29609, France

  • Hopital DUPUYTREN

    Limoges, 87042, France

  • Hopital Jolimont

    Haine-Saint-Paul, 7100, Belgium

  • Hopital NECKER

    Paris, 75743, France

  • Hopital René Huguenin

    Saint-Cloud, 92210, France

  • Hopital St-Louis

    Paris, 75475, France

  • Hopital de la Milétrie

    Poitiers, 86021, France

  • IUCT Oncopole

    Toulouse, 31100, France

  • Institut Gustave ROUSSY

    Villejuif, 94805, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut d'Hématologie de Basse Normandie

    Caen, 14033, France

  • Institut de Cancérologie Strasbourg Europe

    Strasbourg, 67033, France

  • Institut de Cancérologie de la Loire Lucien Neuwirth

    Saint-Priest-en-Jarez, 42270, France

  • Norfolk and Norwich University Hospitals NHS Foundation Trust

    Norwich, NR4 7UY, United Kingdom

  • Oxford University Hospitals NHS Foundation Trust

    Oxford, OX3 7LE, United Kingdom

  • Royal Cornwall Hospital Trust

    Truro, TR1 3LJ, United Kingdom

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • Universite Catholique de Louvain Mont Godinne

    Yvoir, 5530, Belgium

  • Universite Libre de Bruxelles - Hopital ERASME

    Brussels, 1070, Belgium

  • University Hospitals Plymouth NHS Trust

    Plymouth, PL6 8DH, United Kingdom

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