New hope for Hard-to-Treat breast cancer: targeted combo trial launches

NCT ID NCT07393321

First seen Feb 06, 2026 · Last updated May 14, 2026 · Updated 13 times

Summary

This phase 3 trial tests whether adding the experimental drug NTQ1062 to standard hormone therapy (fulvestrant) can slow or stop cancer growth in people with advanced HR+/HER2- breast cancer that has specific genetic changes (PIK3CA/AKT1/PTEN). About 210 adults whose cancer worsened after prior hormone therapy will receive either the combo or a placebo plus fulvestrant. The study aims to see if the new drug extends time without cancer progression.

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