New combo tackles lung cancer after standard treatment fails

NCT ID NCT06029127

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study tested a new drug called gimistotug (BGB-A445) combined with other experimental drugs in 35 people with advanced non-small cell lung cancer who had already received standard treatments like immunotherapy and chemotherapy. The main goal was to see if the combination could shrink tumors. Researchers also monitored side effects. The study is complete, and results will help guide future treatment options.

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Contacts and locations

Locations

  • Affiliated Hospital of Jiangnan University South Campus

    Wuxi, Jiangsu, 214122, China

  • Cancer Hospital Chinese Academy of Medical Sciences

    Beijing, Beijing Municipality, 100021, China

  • Daping Hospital, Third Military Medical University

    Chongqing, Chongqing Municipality, 400042, China

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200000, China

  • Gansu Provincial Hospital

    Lanzhou, Gansu, 730000, China

  • Harbin Medical University Cancer Hospital

    Harbin, Heilongjiang, 150000, China

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450000, China

  • National Cancer Center

    Goyang-si, Gyeonggi-do, 10408, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, Seoul Teugbyeolsi, 03722, South Korea

  • Shanxi Provincial Cancer Hospital

    Taiyuan, Shanxi, 030013, China

  • The Catholic University of Korea, St Vincents Hospital

    Suwon, Gyeonggi-do, 16247, South Korea

  • The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

    Guangzhou, Guangdong, 510405, China

  • The First Affiliated Hospital of Nanchang University Branch Donghu

    Nanchang, Jiangxi, 330006, China

  • The Second Affiliated Hospital of Shandong First Medical University

    Taian, Shandong, 271099, China

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011, China

  • Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • Weihai Municipal Hospital

    Weihai, Shandong, 264299, China

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

Conditions

Explore the condition pages connected to this study.