New drug duo battles Tough-to-Treat skin cancer in major trial

NCT ID NCT06346067

Summary

This study is testing whether a new combination of two drugs, naporafenib and trametinib, works better than current standard treatments for people with advanced NRAS-mutant melanoma that has continued to grow after immunotherapy. The trial will compare how long patients live without their cancer getting worse and their overall survival. It is for adults whose melanoma has spread and cannot be removed by surgery.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • APHP - Hopital Saint Louis

    Paris, 9001, France

  • Alfred Hospital

    Melbourne, 3004, Australia

  • Assistance Publique Hopitaux de Marseille (AP-HM) - Hopital de la Timone

    Marseille, 13005, France

  • Azienda Sanitaria Universitaria del Friuli Centrale

    Udine, 33100, Italy

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • CHRU de Lille - Hôpital Claude Huriez

    Lille, 59000, France

  • CHU Dijon Bourgogne - Hopital Francois Mitterand (Hopital du Bocage)

    Dijon, 21079, France

  • CLCC Institute Gustave Roussy

    Villejuif, 94805, France

  • Calvary Mater Newcastle

    Waratah, New South Wales, 2298, Australia

  • Centre Hospitalier Lyon-Sud

    Lyon, 69310, France

  • Centre Hospitalier Universitaire (CHU) de Bordeaux - Hospitalier Saint-Andre

    Bordeaux, 33075, France

  • Centre Hospitalier du Mans

    Le Mans, 72000, France

  • Christie Hospital

    Manchester, M20 4GJ, United Kingdom

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Fakultni nemocnice Hradec Kralove

    Nový Hradec Králové, 50005, Czechia

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • Hollywood Private Hospital

    Nedlands, Western Australia, 6009, Australia

  • Hospital Ambroise Pairs

    Paris, 75010, France

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital General Universitario Gregorio Marañón

    Madrid, 28007, Spain

  • Hospital HM Sanchinarro

    Madrid, 28050, Spain

  • Hospital Universitari Vall d'Hebron - Vall d'Hebron Institut d'Oncologia (VHIO)

    Barcelona, 08035, Spain

  • Hospital Universitario Central de Asturias

    Oviedo, 33011, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • IRCCS Istituto Nazionale Tumori Regina Elena

    Roma, 00144, Italy

  • Isala Ziekenhuis

    Amsterdam, 8025, Netherlands

  • Istituto Dermopatico dell Immacolata IDI-IRCCS

    Roma, 00167, Italy

  • Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele (HSR) (Istituto Scientifico Universitario Sa

    Milan, 20132, Italy

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZC, Netherlands

  • Masarykuv Onkologicky Ustav-MOU

    Brno, 65653, Czechia

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 70121, United States

  • Mayo Clinic - Arizona

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic - Florida

    Jacksonville, Florida, 70121, United States

  • McGill University Health Centre

    Montreal, Quebec, H4A3J1, Canada

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Ochsner Clinic Foundation

    Jefferson, Louisiana, 70121, United States

  • Peter MacCallum Cancer Institute

    Melbourne, Victoria, 3000, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Queen Elizabeth II Health Sciences Centre

    Halifax, Nova Scotia, B3J 3R4, Canada

  • Radboud University

    Nijmegen, 6525 GA, Netherlands

  • Royal Devon and Exeter Hospital

    Exeter, EX25DW, United Kingdom

  • Royal Preston Hospital

    Preston, Lancashire, PR29H, United Kingdom

  • SCRI Oncology Partners (formerly Tennessee Oncology)

    Nashville, Tennessee, 37203, United States

  • Sanatorium Profesora Arenbergera

    Prague, 1502, Czechia

  • Sarah Cannon Research Institute - HCA Healthcare

    City of London, London, W1G 6AD, United Kingdom

  • Tasman Health Care

    Southport, Queensland, 4215, Australia

  • Texas Oncology - Baylor Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • Texas Oncology- Austin Midtown

    Austin, Texas, 78705, United States

  • The Melanoma and Skin Care Institute

    Englewood, Colorado, 80113, United States

  • The Royal Marsden NHS Foundation Trust

    London, SM2 5PT, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • The University of Utah - Huntsman Cancer Institute (HCI)

    Salt Lake City, Utah, 84112, United States

  • University of California, San Francisco

    San Francisco, California, 94143, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66205, United States

  • University of Miami Sylvester Cancer

    Miami, Florida, 33136, United States

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

  • Virginia Oncology Associates

    Norfolk, Virginia, 23502-1871, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.